Results 31 to 40 of about 1,622 (169)
The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity [PDF]
The Journal of Immunology, 2019 Abstract Complement activation generates the core effector protein C5a, a potent immune molecule that is linked to multiple inflammatory diseases. Two C5a receptors, C5aR1 (C5aR, CD88) and C5aR2 (C5L2, GPR77), mediate the biological activities of C5a.
Xaria X Li +3 more
openaire +5 more sources
C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages [PDF]
The Journal of Immunology, 2020 Abstract The complement activation fragment C5a is a potent proinflammatory mediator that is increasingly recognized as an immune modulator. C5a acts through two C5a receptors, C5aR1 (C5aR, CD88) and C5aR2 (C5L2, GPR77), to powerfully modify multiple aspects of immune cell function.
Xaria X Li +2 more
openaire +4 more sources
Scientific Reports, 2021 Singular blockade of C5a in experimental models of sepsis is known to confer protection by rescuing lethality and decreasing pro-inflammatory responses.
Shinjini Chakraborty +10 more
doaj +1 more source
Helix 8 in chemotactic receptors of the complement system.
PLoS Computational Biology, 2022 Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a and C5a. Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and triggers the G ...
Szymon Wisniewski +3 more
doaj +1 more source
TLQP-21 is a low potency partial C3aR activator on human primary macrophages
Frontiers in Immunology, 2023 TLQP-21 is a 21-amino acid neuropeptide derived from the VGF precursor protein. TLQP-21 is expressed in the nervous system and neuroendocrine glands, and demonstrates pleiotropic roles including regulating metabolism, nociception and microglial functions.
Xaria X. Li +4 more
doaj +1 more source
MicroRNAs affect GPCR and Ion channel genes needed for influenza replication [PDF]
, 2021 Influenza virus causes seasonal epidemics and sporadic pandemics resulting in morbidity, mortality, and economic losses worldwide. Understanding how to regulate influenza virus replication is important for developing vaccine and therapeutic strategies ...
Bakre, Abhijeet +4 more
core +1 more source
Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Sbcutaneous Adipose Tissue and Adipocytes in Acquired Obesity [PDF]
, 2017 Inflammation is an important mediator of obesity-related complications such as the metabolic syndrome but its causes and mechanisms are unknown. As the complement system is a key mediator of inflammation, we studied whether it is activated in acquired ...
Hakkarainen, Antti +14 more
core +1 more source
C3 Drives Inflammatory Skin Carcinogenesis Independently of C5 [PDF]
, 2021 Nonmelanoma skin cancer such as cutaneous squamous cell carcinoma (cSCC) is the most common form of cancer and can occur as a consequence of DNA damage to the epithelium by UVR or chemical carcinogens. There is growing evidence that the complement system
Belmonte, Beatrice +9 more
core +1 more source
Molecular Nutrition &Food Research, Volume 67, Issue 23, December 2023., 2023 Changes occur in the body after eating a high‐fat meal. By assessing published work, the study can conclude that there are common gene expression changes in white blood cells related to oxidative stress and other processes. The term postcibalome is introduced to cover all the changes and responses that occur after consuming a meal.
Aimee L. Dordevic, Gary Williamson
wiley +1 more source
Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis [PDF]
, 2020 none15siopenArbore G.; Ong V.H.; Costantini B.; Denton C.P.; Abraham D.; Placais L.; Blighe K.; Mitchell L.; Ellis R.; Heck S.; Nocerino P.; Woodruff T.M.; Kordasti S.; Kemper C.; Hourcade D.E.Arbore, G.; Ong, V. H.; Costantini, B.; Denton, C.
Abraham D +14 more
core +1 more source