Results 31 to 40 of about 1,082 (137)

Anaphylatoxins spark the flame in early autoimmunity

Frontiers in Immunology, 2022
The complement system (CS) is an ancient and highly conserved part of the innate immune system with important functions in immune defense. The multiple fragments bind to specific receptors on innate and adaptive immune cells, the activation of which ...
Jovan Schanzenbacher, Jörg Köhl, Jörg Köhl, Christian M. Karsten   +3 more
doaj   +1 more source

C5L2 modulates BDNF production in human dental pulp stem cells via p38α pathway

Scientific Reports, 2023
Tissue injury affects nerve fibers and triggers an immune response, leading to inflammation. The complement system gets activated during inflammatory conditions and has been reported to be involved in the regeneration process.
Muhammad Irfan, Seung Chung
doaj   +1 more source

IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction

Frontiers in Immunology, 2018
Background: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their receptors; the highly inflammatory
Hilde L. Orrem, Hilde L. Orrem, Hilde L. Orrem, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Søren E. Pischke, Søren E. Pischke, Søren E. Pischke, Ola Kleveland, Ola Kleveland, Arne Yndestad, Arne Yndestad, Arne Yndestad, Arne Yndestad, Arne Yndestad, Karin Ekholt, Karin Ekholt, Jan K. Damås, Terje Espevik, Bjørn Bendz, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Bente Halvorsen, Ida Gregersen, Ida Gregersen, Rune Wiseth, Rune Wiseth, Geir Ø. Andersen, Geir Ø. Andersen, Geir Ø. Andersen, Thor Ueland, Thor Ueland, Thor Ueland, Thor Ueland, Thor Ueland, Lars Gullestad, Lars Gullestad, Lars Gullestad, Pål Aukrust, Pål Aukrust, Pål Aukrust, Pål Aukrust, Andreas Barratt-Due, Andreas Barratt-Due, Andreas Barratt-Due, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes, Tom E. Mollnes   +54 more
doaj   +1 more source

Role of Complement and Histones in Sepsis

Frontiers in Medicine, 2020
The wide use of the mouse model of polymicrobial sepsis has provided important evidence for events occurring in infectious sepsis involving septic mice and septic humans.
Firas S. Zetoune, Peter A. Ward
doaj   +1 more source

Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis

EBioMedicine, 2020
Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome.
Nathalie Niyonzima, Siril S. Bakke, Ida Gregersen, Sverre Holm, Øystein Sandanger, Hilde L. Orrem, Bjørnar Sporsheim, Liv Ryan, Xiang Yi Kong, Tuva Børresdatter Dahl, Mona Skjelland, Kirsten Krohg Sørensen, Anne Mari Rokstad, Arne Yndestad, Eicke Latz, Lars Gullestad, Geir Ø. Andersen, Jan Kristian Damås, Pål Aukrust, Tom E. Mollnes, Bente Halvorsen, Terje Espevik   +21 more
doaj   +1 more source

Identification of immune-related and autophagy-related genes for the prediction of survival in bladder cancer

BMC Genomic Data, 2022
Background Bladder cancer has the characteristics of high morbidity and mortality, and the prevalence of bladder cancer has been increasing in recent years.
Quanfeng Zhu, Lingdi Zhang, Yaping Deng, Leilei Tang   +3 more
doaj   +1 more source

A Novel Role for C5a in B-1 Cell Homeostasis

Frontiers in Immunology, 2018
B-1 cells constitute a unique subpopulation of lymphocytes residing mainly in body cavities like the peritoneal cavity (PerC) but are also found in spleen and bone marrow (BM).
Katharina Bröker, Julia Figge, Albert F. Magnusen, Rudolf A. Manz, Jörg Köhl, Jörg Köhl, Christian M. Karsten   +6 more
doaj   +1 more source

Urolithin A Exerts Neuroprotective Effects Against Ischemic Stroke by Inhibiting Oxidative Stress and Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Urolithin A (UA) treatment enhances the Nrf2/HO‐1‐mediated antioxidant capacity against ischemic injury postischemic stroke, while also effectively suppressing neuroinflammatory responses. Both of these regulatory effects are likely associated with the NF‐κB signaling pathway, which in turn inhibits neuronal apoptosis and contributes to the improvement
Yanxin Shao, Lina Feng, Yanchun Li, Yichen Cai, Hui Yuan, Qin Tang, Mingfeng Yang, Weixia Yang, Hong Shi, Leilei Mao   +9 more
wiley   +1 more source

Significance of Immune-Related Genes in the Diagnosis and Classification of Intervertebral Disc Degeneration

Journal of Immunology Research, 2022
Background. With the extensive development of intervertebral disc degeneration (IDD) research, IDD has been found to be a complex disease associated with immune-related gene (IRGs) changes. Nonetheless, the roles of IRGs in IDD are unclear. Methods.
Bo Wu, Xinzhou Huang, Mu Zhang, Wei Chu
doaj   +1 more source

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni, Ebba Qviberg, Edward Chaloner, Hayley Lavender, Maisem Laabei   +4 more
wiley   +1 more source