Efficacy and safety of Vilobelimab (IFX-1), a novel monoclonal anti-C5a antibody, in patients with early severe sepsis or septic shock — a randomized, placebo-controlled, double-blind, multicenter, phase IIa Trial (SCIENS Study) [PDF]
, 2021 IMPORTANCE:. Anaphylatoxin C5a, a proinflammatory complement split product, plays a central role in mediating organ dysfunction. OBJECTIVES:. This phase II clinical trial was conducted to study safety, tolerability, pharmacokinetics, and pharmacodynamics
Achim Jörres, MD +21 more
core +1 more source
Anaphylatoxins spark the flame in early autoimmunity
Frontiers in Immunology, 2022 The complement system (CS) is an ancient and highly conserved part of the innate immune system with important functions in immune defense. The multiple fragments bind to specific receptors on innate and adaptive immune cells, the activation of which ...
Jovan Schanzenbacher +3 more
doaj +1 more source
The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets [PDF]
, 2021 Platelets contribute to the regulation of tissue neovascularization, although the specific factors underlying this function are unknown. Here, we identified the complement anaphylatoxin C5a-mediated activation of C5a receptor 1 (C5aR1) on platelets as a ...
Baron, Lasse +26 more
core +1 more source
A whole-blood transcriptome meta-analysis identifies gene expression signatures of cigarette smoking [PDF]
, 2016 Cigarette smoking is a leading modifiable cause of death worldwide. We hypothesized that cigarette smoking induces extensive transcriptomic changes that lead to target-organ damage and smoking-related diseases.
Bandinelli, S. (Stefania) +32 more
core +1 more source
Specific inhibition of complement activation significantly ameliorates autoimmune blistering disease in mice [PDF]
, 2018 Epidermolysis bullosa acquisita (EBA) is an antibody-mediated blistering skin disease associated with tissue-bound and circulating autoantibodies to type VII collagen (COL7).
B. Paul Morgan +11 more
core +3 more sources
C5L2 modulates BDNF production in human dental pulp stem cells via p38α pathway
Scientific Reports, 2023 Tissue injury affects nerve fibers and triggers an immune response, leading to inflammation. The complement system gets activated during inflammatory conditions and has been reported to be involved in the regeneration process.
Muhammad Irfan, Seung Chung
doaj +1 more source
Role of Complement and Histones in Sepsis
Frontiers in Medicine, 2020 The wide use of the mouse model of polymicrobial sepsis has provided important evidence for events occurring in infectious sepsis involving septic mice and septic humans.
Firas S. Zetoune, Peter A. Ward
doaj +1 more source
Successful pharmacological intervention at different levels of the complement system in an in vitro complement fixation model for bullous pemphigoid [PDF]
, 2023 Bullous pemphigoid (BP) is characterized by deposition of immunoglobulins and complement along the epidermal basement membrane (BM). In humans, there is a lack of functional studies targeting the complement system (CS). This study investigates activation
Damman, Jeffrey +7 more
core +5 more sources
Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis [PDF]
, 2014 The epithelial complement inhibitory proteins (CIPs) cluster of differentiation 46 and 55 (CD46 and CD55) regulate circulating immune complex-mediated complement activation in idiopathic pulmonary fibrosis (IPF). Our previous studies demonstrated that IL-
Cummings, Oscar W. +8 more
core +1 more source
EBioMedicine, 2020 Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome.
Nathalie Niyonzima +21 more
doaj +1 more source