Results 51 to 60 of about 1,082 (137)
Old disease—New reflections: Gaucher, immunity, and inflammation
Journal of Cellular and Molecular Medicine, Volume 28, Issue 20, October 2024.Abstract Gaucher disease (GD) is the most common lysosomal storage disease. It is a multisystemic metabolic disease caused by GBA pathogenic mutations. Although the general symptoms have been known for a long time, new treatment possibilities, the detection of different biomarkers, and innovations in diagnosis and follow‐up have paved the way for ...
Can Veysel Şoroğlu, Ezgi Gizem Berkay
wiley +1 more source
The Second Receptor for C5a, C5aR2, Is Detrimental to Mice during Systemic Infection with Listeria monocytogenes [PDF]
The Journal of Immunology, 2019 Abstract Infection with Listeria monocytogenes is acquired through ingestion of contaminated foods and may lead to systemic infection and possible death, with an overall 20% mortality rate. Our previous work using C5aR1−/− mice and C3aR−/− mice demonstrated that C5aR1 and C3aR both play powerful anti-inflammatory and prosurvival roles ...
Stacey L Mueller-Ortiz +2 more
openaire +2 more sources
Crepuscular rays — The bright side of complement after tissue injury
European Journal of Immunology, Volume 54, Issue 9, September 2024.Traumatic injuries elicit an activation of the complement system. Due to its overwhelming nature, it's often described as harmful, while its protective effects are overlooked. This review focuses on and summarizes the advantageous aspects of complement shining as “sunbeams” through the otherwise negative‐afflicted “clouds” (i.e.
Marco Mannes +4 more
wiley +1 more source
Cardiotrophin‐1 therapy reduces disease severity in a murine model of glomerular disease
Physiological Reports, Volume 12, Issue 13, July 2024.Abstract Cardiotrophin‐1 (CT‐1), a member of the interleukin (IL)‐6 cytokine family, has renoprotective effects in mouse models of acute kidney disease and tubulointerstitial fibrosis, but its role in glomerular disease is unknown. To address this, we used the mouse model of nephrotoxic nephritis to test the hypothesis that CT‐1 also has a protective ...
Nuria Perretta‐Tejedor +7 more
wiley +1 more source
The Journal of Pathology, Volume 262, Issue 2, Page 161-174, February 2024.Abstract Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by autoantibodies targeting type XVII collagen (Col17) with the noncollagenous 16A (NC16A) ectodomain representing the immunodominant site. The role of additional extracellular targets of Col17 outside NC16A has not been unequivocally demonstrated.
Manuela Pigors +18 more
wiley +1 more source
The complement cascade in lung injury and disease
Respiratory ResearchBackground The complement system is an important arm of immune defense bringing innate and adaptive immunity. Although originally regarded as a major complementary defense mechanism against pathogens, continuously emerging evidence has uncovered a ...
M. G. Detsika +4 more
doaj +1 more source
Die atheroprotektive Rolle der C5aR2 Defizienz in Apolipoprotein E defizienten Mäusen
, 2017 Published by ...
openaire +2 more sources
补体在主要组织相容性抗原Ⅰ类抗体介导的输血相关急性肺损伤中的作用
Zhongshan Daxue xuebao. Yixue kexue ban目的输血相关急性肺损伤（TRALI）是一种常见的致死性输血不良反应，主要组织相容性抗原（MHC）Ⅰ类抗体是引起TRALI的重要因素，但补体在其发病机制中的作用尚未完全阐明。本研究旨在探索补体在MHC-Ⅰ类抗体介导TRALI中的作用，为临床防治提供理论依据。方法本研究利用“二次打击”理论建立TRALI小鼠模型，首次打击采用脂多糖（LPS），第二次打击采用MHC-Ⅰ类抗体。将雄性Balb/c小鼠随机分为7组，分别命名为Naïve（空白对照）、LPS（仅首次打击）、Isotype（同型抗体对照）、TRALI ...
张泽 +4 more
doaj