Results 71 to 80 of about 1,622 (169)
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
C5aR2 in Breast Cancer and Its Relationship with Clinicopathological Features
Journal of the College of Physicians and Surgeons PakistanTo determine the relation between C5aR2 and clinicopathological parameters of breast cancer. Study Design: Observational study. Place and Duration of the Study: Department of Histopathology, PNS
Erum, Khaliq +2 more
openaire +2 more sources
Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat
Physiological Reports, Volume 13, Issue 21, November 2025.Abstract Ischemia‐reperfusion injury (IRI) is the central contributing factor to acute kidney injury (AKI). Kidney tissue that becomes necrotic during this process releases a variety of pro‐inflammatory factors, driving activation of the complement cascade.
Madison McGraw +7 more
wiley +1 more source
C5aR1 Activation Drives Early IFN-gamma Production to Control ExperimentalToxoplasma gondiiInfection [PDF]
, 2020 Toxoplasma gondii (T. gondii) is a parasite infecting animals and humans. In intermediate hosts, such as humans or rodents, rapidly replicating tachyzoites drive vigorous innate and adaptive immune responses resulting in bradyzoites that survive within ...
Aliberti, Julio +7 more
core +1 more source
From Bat to Worse: The Pivotal Role of Bats for Viral Zoonosis
Microbial Biotechnology, Volume 18, Issue 7, July 2025.Thanks to a dampened inflammatory innate immune response, various Chiropteran (bat) species frequently carry ‐ without showing symptoms – diverse viruses that can cause severe diseases in humans. The reasons why bats are a pivotal virus reservoir for emerging viral diseases are discussed in this Lilliput contribution.
Harald Brüssow
wiley +1 more source
Complement anaphylatoxins: Potential therapeutic target for diabetic kidney disease
Diabetic Medicine, Volume 42, Issue 2, February 2025.Abstract Diabetic kidney disease (DKD) is the most common cause of kidney failure, characterized by chronic inflammation and fibrosis. The complement system is increasingly implicated in the development and progression of diabetic nephropathy. The important complement anaphylatoxins C3a and C5a are key mediators of the innate immune system, which ...
Jingyuan Ma +2 more
wiley +1 more source
Complement as a regulator of adaptive immunity [PDF]
, 2017 International audienceThe complement system is an ancient and evolutionarily conserved effector system comprising in mammals over 50 circulating and membrane bound proteins.
Astier, Anne +3 more
core +4 more sources
The complement system: A key player in the host response to infections
European Journal of Immunology, Volume 54, Issue 11, November 2024.Duality of the complement system during infection: An adequate immune defense clears the infection and restores tissue resilience, whereas a maladaptive response due to complement hyperactivation results in hyperinflammation and tissue injury, as seen in sepsis and pneumonia.
Archana Jayaraman +2 more
wiley +1 more source
Old disease—New reflections: Gaucher, immunity, and inflammation
Journal of Cellular and Molecular Medicine, Volume 28, Issue 20, October 2024.Abstract Gaucher disease (GD) is the most common lysosomal storage disease. It is a multisystemic metabolic disease caused by GBA pathogenic mutations. Although the general symptoms have been known for a long time, new treatment possibilities, the detection of different biomarkers, and innovations in diagnosis and follow‐up have paved the way for ...
Can Veysel Şoroğlu, Ezgi Gizem Berkay
wiley +1 more source
Crepuscular rays — The bright side of complement after tissue injury
European Journal of Immunology, Volume 54, Issue 9, September 2024.Traumatic injuries elicit an activation of the complement system. Due to its overwhelming nature, it's often described as harmful, while its protective effects are overlooked. This review focuses on and summarizes the advantageous aspects of complement shining as “sunbeams” through the otherwise negative‐afflicted “clouds” (i.e.
Marco Mannes +4 more
wiley +1 more source