Results 61 to 70 of about 1,622 (169)

Identification of immune-related and autophagy-related genes for the prediction of survival in bladder cancer

BMC Genomic Data, 2022
Background Bladder cancer has the characteristics of high morbidity and mortality, and the prevalence of bladder cancer has been increasing in recent years.
Quanfeng Zhu, Lingdi Zhang, Yaping Deng, Leilei Tang   +3 more
doaj   +1 more source

Ligand-binding and -scavenging of the chemerin receptor GPR1 [PDF]

, 2021
Tight regulation of cytokines is essential for the initiation and resolution of inflammation. Chemerin, a mediator of innate immunity, mainly acts on chemokine-like receptor 1 (CMKLR1) to induce the migration of macrophages and dendritic cells.
Beck-Sickinger, Annette, Czerniak, Anne Sophie, Fischer, Tobias F., Meiler, Jens, Schoeder, Clara, Seitz, Oliver, Weiß, Tina, Wolf, Philipp   +7 more
core   +1 more source

A Novel Role for C5a in B-1 Cell Homeostasis

Frontiers in Immunology, 2018
B-1 cells constitute a unique subpopulation of lymphocytes residing mainly in body cavities like the peritoneal cavity (PerC) but are also found in spleen and bone marrow (BM).
Katharina Bröker, Julia Figge, Albert F. Magnusen, Rudolf A. Manz, Jörg Köhl, Jörg Köhl, Christian M. Karsten   +6 more
doaj   +1 more source

Role of extracellular histones in the cardiomyopathy of sepsis [PDF]

, 2015
The purpose of this study was to define the relationship in polymicrobial sepsis (in adult male C57BL/6 mice) between heart dysfunction and the appearance in plasma of extracellular histones.
Bosmann, Markus, Campbell, Katherine F., Fattahi, Fatemeh, Gebhard, Florian, Grailer, Jamison J., Herron, Todd J., Huber‐lang, Markus, Jajou, Lawrence, Jalife, José, Kalbitz, Miriam, Loaiza, Randall, Russell, Mark W., Sarma, J. Vidya, Valdivia, Hector H., Ward, Peter A., Zetoune, Firas S.   +15 more
core   +1 more source

Significance of Immune-Related Genes in the Diagnosis and Classification of Intervertebral Disc Degeneration

Journal of Immunology Research, 2022
Background. With the extensive development of intervertebral disc degeneration (IDD) research, IDD has been found to be a complex disease associated with immune-related gene (IRGs) changes. Nonetheless, the roles of IRGs in IDD are unclear. Methods.
Bo Wu, Xinzhou Huang, Mu Zhang, Wei Chu
doaj   +1 more source

Comparative Transcriptomic Analysis of Human Macrophages During Mycobacterium avium Versus Mycobacterium tuberculosis Infection

Molecular Microbiology, Volume 125, Issue 3, Page 185-202, March 2026.
Human macrophage transcriptomic responses to Mycobacterium avium (Mav), a major cause of nontuberculous lung disease, were compared to Mycobacterium tuberculosis (Mtb). Both infections activated overlapping immune pathways, including cytokine signaling and GPCRs involved in lipid metabolism, while phospholipases were more strongly regulated by Mav and ...
Gül Kilinç, Robin H. G. A. van den Biggelaar, Tom H. M. Ottenhoff, Leon H. Mei, Anno Saris   +4 more
wiley   +1 more source

Evaluation of the Safety and Efficacy of Avacopan, a C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Treated Concomitantly With Rituximab or Cyclophosphamide/Azathioprine: Protocol for a Randomized, Double-Blind, Active-Controlled, Phase 3 Trial

JMIR Research Protocols, 2020
BackgroundAntineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a serious, often life-threatening disease. In new-onset disease or a relapse, the standard treatment is immunosuppressive therapy with glucocorticoids; these therapies are ...
Merkel, Peter A, Jayne, David R, Wang, Chao, Hillson, Jan, Bekker, Pirow   +4 more
doaj   +1 more source

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. [PDF]

, 2019
Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but pathophysiological impact resulting from spatiotemporal dynamics of macrophages is unknown.
Edgerton, V Reggie, Hara, Masamitsu, Harimaya, Katsumi, Inoue, Kazuhide, Iwamoto, Yukihide, Kijima, Ken, Kobayakawa, Kazu, Kubota, Kensuke, Masuda, Takahiro, Matsumoto, Yoshihiro, Nakashima, Yasuharu, Ohkawa, Yasuyuki, Okada, Seiji, Ozato, Keiko, Saito, Takeyuki, Tamaru, Tetsuya, Tamura, Tomohiko, Tsuda, Makoto, Yokota, Kazuya, Yoshizaki, Shingo   +19 more
core   +1 more source

The Complement System in ANCA‐Associated Vasculitis: Mechanistic Insights, Therapeutic Horizons, and Unmet Clinical Needs

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
Complement activation, particularly via the alternative pathway, drives inflammation and organ damage in ANCA‐associated vasculitis. This review highlights mechanistic insights, tissue and biomarker evidence, and clinical implications of targeting the C5a–C5aR1 axis.
Kehinde Sunmboye, Pauline Millan
wiley   +1 more source

Complement peptide receptors in GtoPdb v.2023.1 [PDF]

, 2023
Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [113]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement ...
Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xaria X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A., Woodruff, Trent M.   +8 more
core   +2 more sources