Results 81 to 90 of about 1,622 (169)

Astrocyte activation and reactive gliosis : A new target in stroke? [PDF]

, 2019
Stroke is an acute insult to the central nervous system (CNS) that triggers a sequence of responses in the acute, subacute as well as later stages, with prominent involvement of astrocytes.
Akers, Allen, Bajic, Balasingam, Bardehle, Barkho, Benoit, Benowitz, Bialas, Biggins, Bossi, Bradbury, Bradbury, Brennan, Buffo, Bunketorp-Käll, Bush, Bushong, Cantiello, Cantiello, Cho, Choi, Christopherson, Chung, Clarke, Clarkson, David, Davoust, de Pablo, de Pablo, De Simoni, Ding, Ducruet, Eliasson, Eriksson, Eroglu, Feigin, Fonseca, Garber, Garrett, Gasque, Gasque, Gavrilyuk, Gong, Goritz, Goss, Grosche, Gustavsson, Haj-Yasein, Harder, Hol, Hooshmand, Hostenbach, Howell, Hung, Iadecola, Iliff, Iram, Ischenko, Jarlestedt, Jauneau, Jauneau, Jing, Justicia, Järlestedt, Kim, Kimelberg, Kinouchi, Klein, Koehler, Kraft, Kucukdereli, Laplagne, Larsson, Lebkuechner, Lee, Lepekhin, Li, Lian, Liauw, Liddelow, Lie, Lin, Liu, Lozano, Lu, Lu, Lundkvist, Macauley, Magnusson, Manley, Marcela Pekna, Menet, Middeldorp, Milos Pekny, Mocco, Moran, Moran, Moran, Mulligan, Myer, Nakazawa, Nataf, Nilsson, Norris, Oberheim, Overman, Pallari, Papadopoulos, Pasantes-Morales, Pavlovski, Pekna, Pekny, Pekny, Pekny, Pekny, Pekny, Pekny, Pekny, Pekny, Pekny, Pekny, Peterson, Plog, Potokar, Potokar, Rabchevsky, Rahpeymai, Rolls, Rynkowski, Sahay, Sanchez-Olea, Sayah, Sayah, Schafer, Sharma, Shinjyo, Shinjyo, Shinozaki, Sihlbom, Sofroniew, Sofroniew, Song, Sriram, Stahlberg, Steiner, Steiner, Stephan, Stevens, Stogsdill, Stokowska, Stokowska, Tashiro, Ten, Ten, Toni, Turgut Tatlisumak, Ullian, Ulrika Wilhelmsson, van Asch, van Beek, van Beek, Vardjan, Verardo, Verkhratsky, Verkhratsky, Verkhratsky, Vitarella, Wang, Widestrand, Wieloch, Wilhelmsson, Wilhelmsson, Wilhelmsson, Wilhelmsson, Winter, Wu, Wunderlich, Yick, Zamanian, Zhang, Zhang, Zhao   +182 more
core   +1 more source

Cardiotrophin‐1 therapy reduces disease severity in a murine model of glomerular disease

Physiological Reports, Volume 12, Issue 13, July 2024.
Abstract Cardiotrophin‐1 (CT‐1), a member of the interleukin (IL)‐6 cytokine family, has renoprotective effects in mouse models of acute kidney disease and tubulointerstitial fibrosis, but its role in glomerular disease is unknown. To address this, we used the mouse model of nephrotoxic nephritis to test the hypothesis that CT‐1 also has a protective ...
Nuria Perretta‐Tejedor, Karen L. Price, Daniyal J. Jafree, Gideon Pomeranz, Maria Kolatsi‐Joannou, Carlos Martínez‐Salgado, David A. Long, Elisavet Vasilopoulou   +7 more
wiley   +1 more source

C3aR and C5aR1 act as key regulators of human and mouse β-cell function [PDF]

, 2017
Aims: Complement components 3 and 5 (C3 and C5) play essential roles in the complement system, generating C3a and C5a peptides that are best known as chemotactic and inflammatory factors.
Amisten, Stefan, Atanes, Patricio, Hawkes, Ross, Huang, Guo Cai, Liu, Bo, Persaud, Shanta J., Pingitore, Attilio, Ruz Maldonado, Inmaculada, Zhao, Min   +8 more
core   +2 more sources

Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects [PDF]

, 2017
During sepsis, excessive activation of the complement system with generation of the anaphylatoxin C5a results in profound disturbances in crucial neutrophil functions.
Denk, Stephanie, et al, Messerer, David A C, Neher, Miriam D, Nilsson, Bo, Rittirsch, Daniel, Wiegner, Rebecca   +6 more
core   +1 more source

Bullous pemphigoid induced by IgG targeting type XVII collagen non‐NC16A/NC15A extracellular domains is driven by Fc gamma receptor‐ and complement‐mediated effector mechanisms and is ameliorated by neonatal Fc receptor blockade

The Journal of Pathology, Volume 262, Issue 2, Page 161-174, February 2024.
Abstract Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by autoantibodies targeting type XVII collagen (Col17) with the noncollagenous 16A (NC16A) ectodomain representing the immunodominant site. The role of additional extracellular targets of Col17 outside NC16A has not been unequivocally demonstrated.
Manuela Pigors, Sabrina Patzelt, Niklas Reichhelm, Jenny Dworschak, Stanislav Khil'chenko, Shirin Emtenani, Katja Bieber, Maxi Hofrichter, Mayumi Kamaguchi, Stephanie Goletz, Gabriele Köhl, Jörg Köhl, Lars Komorowski, Christian Probst, Katrien Vanderheyden, Bianca Balbino, Ralf J Ludwig, Peter Verheesen, Enno Schmidt   +18 more
wiley   +1 more source

Investigating the Signalling and Function of C5aR2

, 2023
APPROVED
openaire   +1 more source

The Second Receptor for C5a, C5aR2, Is Detrimental to Mice during Systemic Infection with Listeria monocytogenes [PDF]

The Journal of Immunology, 2019
Abstract Infection with Listeria monocytogenes is acquired through ingestion of contaminated foods and may lead to systemic infection and possible death, with an overall 20% mortality rate. Our previous work using C5aR1−/− mice and C3aR−/− mice demonstrated that C5aR1 and C3aR both play powerful anti-inflammatory and prosurvival roles ...
Stacey L Mueller-Ortiz, Pooja Shivshankar, Rick A Wetsel   +2 more
openaire   +2 more sources

Complementâ induced activation of the cardiac NLRP3 inflammasome in sepsis [PDF]

, 2016
Cardiac dysfunction develops during sepsis in humans and rodents. In the model of polymicrobial sepsis induced by cecal ligation and puncture (CLP), we investigated the role of the NLRP3 inflammasome in the heart.
Fattahi, Fatemeh, Grailer, Jamison J., Huber‐lang, Markus, Jajou, Lawrence, Kalbitz, Miriam, Malan, Elizabeth A., Russell, Mark W., Ward, Peter A., Zetoune, Firas S.   +8 more
core   +1 more source

Exome-wide association study of pancreatic cancer risk [PDF]

, 2018
We conducted a case-control exome-wide association study to discover germline variants in coding regions that affect risk for pancreatic cancer, combining data from 5 studies. We analyzed exome and genome sequencing data from 437 patients with pancreatic
Biankin, Andrew, Borgida, Ayelet, Cleary, Sean, Connor, Ashton A., Cook, Natalie, Denroche, Robert E., Gallinger, Steven, Grant, Robert C., Grimmond, Sean M., Klein, Alison P., Lemire, Mathieu, Moore, Malcolm, Peterson, Gloria, Roberts, Nicholas J., Smith, Alyssa L., Stein, Lincoln, Virtanen, Carl, Wilson, Julie M., Zogopolous, George   +18 more
core   +1 more source

The complement cascade in lung injury and disease

Respiratory Research
Background The complement system is an important arm of immune defense bringing innate and adaptive immunity. Although originally regarded as a major complementary defense mechanism against pathogens, continuously emerging evidence has uncovered a ...
M. G. Detsika, K. Palamaris, I. Dimopoulou, A. Kotanidou, S. E. Orfanos   +4 more
doaj   +1 more source