Results 101 to 110 of about 1,082 (137)

Expression of innate immunity genes in human hematopoietic stem/progenitor cells - single cell RNA-seq analysis. [PDF]

Front Immunol
Jarczak J, Thetchinamoorthy K, Wierzbicka D, Bujko K, Ratajczak MZ, Kucia M.   +5 more
europepmc   +1 more source

Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation. [PDF]

Respir Res
Shivshankar P, Mueller-Ortiz SL, Domozhirov AY, Bi W, Collum SD, Doursout MF, Patel M, LeFebvre IN, Akkanti B, Yau S, Huang HJ, Hussain R, Karmouty-Quintana H.   +12 more
europepmc   +1 more source

Carboxypeptidase M deficiency aggravates complement-induced lung injury. [PDF]

iScience
Qadri F, Zhang C, Schütz A, Popova E, Czaplinska BA, Zemechmann K, Greckl R, Alenina N, Pesquero JB, Rodrigues AF, Bader M.   +10 more
europepmc   +1 more source

G protein coupled receptor transcripts in human immune cells and platelets. [PDF]

Sci Data
Hansen A, Martin D, Langer F, Harrison K, Kehrl J, Cicala C, Martinelli E, Brownstein MJ, Mezey E.   +8 more
europepmc   +1 more source

The Complement System in the Setting of Critical Illness-A Narrative Review. [PDF]

Biomolecules
Ampelakiotou K, Nikitopoulou I, Kokkoris S, Kotanidou A, Dimopoulou I, Detsika MG.   +5 more
europepmc   +1 more source

Complement biosynthesis in human brain: Insights from single-nucleus transcriptomics of hippocampus

Nguyen VD, Bright M, Zhou Y, Morgan BP, Zelek WM.   +4 more
europepmc   +1 more source

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C5aR2 receptor: The genomic twin of the flamboyant C5aR1

Journal of Cellular Biochemistry, 2022
AbstractThe complement fragment C5a is one of the most potent proinflammatory glycoproteins liberated by the activation of the biochemical cascade of the complement system. C5a is established to interact with a set of genomically related transmembrane receptors, like C5aR1 (CD88, C5aR) and C5aR2 (GPR77, C5L2) with comparable affinity.
Soumendra Rana
exaly   +3 more sources

The C5a/C5aR2 axis promotes renal inflammation and tissue damage [PDF]

JCI Insight, 2020
C5a is a potent inflammatory mediator that binds C5aR1 and C5aR2. Although pathogenic roles of the C5a/C5aR1 axis in inflammatory disorders are well documented, the roles for the C5a/C5aR2 axis in inflammatory disorders and underlying mechanisms remain unclear. Here, we show that the C5a/C5aR2 axis contributes to renal inflammation
Ting Zhang, Ke Li, Wuding Zhou
exaly   +3 more sources

C5aR2

2018
The second receptor for C5a is a new addition to the complement family since the first edition of this book. It was discovered in 2000 and, despite its relatively short history, its function has been the subject of controversy. The genetic locus for this receptor consists of two exons separated by a large intron, a structure it shares with C5aR1. C5aR2
Owen A Hawksworth, Trent M. Woodruff, Liam G Coulthard   +2 more
exaly   +5 more sources

Ternary model structural complex of C5a, C5aR2, and β-arrestin1

Journal of Biomolecular Structure and Dynamics, 2023
Complement component fragment 5a (C5a) is one of the potent proinflammatory modulators of the complement system. C5a recruits two genomically related G protein-coupled receptors (GPCRs), like C5aR1 and C5aR2, constituting a binary complex. The C5a-C5aR1/C5aR2 binary complexes involve other transducer proteins like heterotrimeric G-proteins and β ...
Pulkit Kr, Gupta, Aurosikha, Das, Aditi, Singh, Soumendra, Rana   +3 more
openaire   +2 more sources