Results 111 to 120 of about 1,082 (137)

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling [PDF]

Immunology and Cell Biology, 2016
The complement cascade is comprised of a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue injury. The complement activation peptide, C5a, binds two seven transmembrane receptors, namely the C5a receptor 1 (C5aR1) and C5a receptor 2 (C5aR2, or C5L2). C5aR2 is a non‐G‐protein‐signalling
Daniel Croker, Richard J. Clark, Dimitrios Morikis   +2 more
exaly   +7 more sources

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Double Deletion of C5aR1 and C5aR2 during Streptococcal Pneumonia

The Journal of Immunology, 2020
Abstract The complement system is essential for the clearance of encapsulated bacteria such as Streptococcus pneumoniae (Spn), recognized as a major pathogen of pneumonia. Yet, it is not entirely clear whether C5 and its activation product C5a have beneficial or detrimental effects on the outcome of Spn infection.
Sarah Walachowski, Markus Dudek, Leonid Eshkind, Vanessa Tansi, Joseph P Mizgerd, Markus Bosmann   +5 more
openaire   +1 more source

Critical role for complement receptor C5aR2 in the pathogenesis of renal ischemia-reperfusion injury

FASEB Journal, 2017
ABSTRACT The complement system, and specifically C5a, is involved in renal ischemia‐reperfusion (IR) injury. The 2 receptors for complement anaphylatoxin C5a (C5aR1 and C5aR2) are expressed on leukocytes as well as on renal epithelium. Extensive evidence shows that C5aR1 inhibition protects kidneys from IR injury;
Henri Leuvenink, Jeffrey Damman, Ronald van Os   +2 more
exaly   +7 more sources

Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice

Thrombosis and Haemostasis, 2015
SummaryAtherogenic processes and vascular remodelling after arterial injury are controlled and driven by a plethora of factors amongst which the activation of the complement system is pivotal. Recently, we reported a clear correlation between high expressions of the second receptor for complement anaphylatoxin C5a, the C5a receptor-like 2 (C5L2, C5aR2),
Selle, Jaco, Asare, Yaw, Kohncke, Janine, Alampour-Rajabi, Setareh, Shagdarsuren, Gansuvd, Klos, Andreas, Weber, Christian, Jankowski, Joachim, Shagdarsuren, Erdenechimeg   +8 more
openaire   +3 more sources

The Alternative Receptor for Complement Component 5a, C5aR2, Conveys Neuroprotection in Traumatic Spinal Cord Injury [PDF]

Journal of Neurotrauma, 2017
This study investigated the role of the alternative receptor for complement activation fragment C5a, C5aR2, in secondary inflammatory pathology after contusive spinal cord injury (SCI) in mice. C5ar2-/- mice exhibited decreased intraparenchymal tumor necrosis factor alpha and interleukin-6 acutely post-injury, but these reductions did not translate ...
Marc J. Ruitenberg, Faith H Brennan, Trent M. Woodruff   +2 more
exaly   +6 more sources

Neutraligands of C5a can potentially occlude the interaction of C5a with the complement receptors C5aR1 and C5aR2

Journal of Cellular Biochemistry, 2022
AbstractThe complement system is central to the rapid immune response witnessed in vertebrates and invertebrates, which plays a crucial role in physiology and pathophysiology. Complement activation fuels the proteolytic cascade, which produces several complement fragments that interacts with a distinct set of complement receptors.
Aurosikha Das, Manaswini Ghosh, Pulkit Kr. Gupta, Soumendra Rana   +3 more
openaire   +2 more sources

C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma

FASEB Journal, 2019
ABSTRACT The canonical complement component 5a (C5a) receptor (C5aR) 1 has well‐described roles in tumorigenesis but the contribution of the second receptor, C5aR2, is unclear. The present study demonstrates that B16.F0 melanoma cells express mRNA for both C5aR1 and
Xaria X Li, Jamileh A Nabizadeh, Barbara E Rolfe   +2 more
exaly   +6 more sources

The Role of the C5a Receptor, C5aR2, in Neurodegenerative Disease

2017
There is increasing evidence that chronic complement activation is involved in numerous neurodegenerative disease states. Parkinson’s disease (PD) and Huntington’s disease (HD) are intractable neurodegenerative diseases characterised by progressive motor and cognitive dysfunction.
openaire   +3 more sources

Igniting the flame in arthritis: C5aR2 controls endothelial transcytosis of C5a

Science Immunology, 2019
C5aR2 transfers arthritic joint-derived C5a to the blood vessel endothelium to start C5aR1-driven neutrophilic inflammation. See related Research Article by Miyabe et al .
openaire   +2 more sources

Complement receptors C5aR1 and C5aR2 differentially influence bone metabolism

2017
Objectives: Activation of the complement system, a crucial arm of innate immunity, leads to the generation of the anaphylatoxin C5a, acting via its receptors C5aR1 and C5aR2. C5aR1 has already been attributed an important role in bone development, regeneration and inflammation, as C5aR1 expression on[for full text, please go to the a.m. URL]
Hägele, Y, Bergdolt, S, Matthes, R, Kovtun, A, Ignatius, A   +4 more
openaire   +2 more sources