Results 91 to 100 of about 1,622 (169)
Complement peptide receptors in GtoPdb v.2025.3 [PDF]
Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [116]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement ...
Cianciulli, Antonia +9 more
core +2 more sources
Experimental design of complement component 5a‐induced acute lung injury (C5a‐ALI): a role of CC‐chemokine receptor type 5 during immune activation by anaphylatoxin [PDF]
, 2015 Excessive activation of the complement system is detrimental in acute inflammatory disorders. In this study, we analyzed the role of complement‐derived anaphylatoxins in the pathogenesis of experimental acute lung injury/acute respiratory distress ...
Bosmann, Markus +5 more
core +1 more source
Complement-mediated kidney diseases: Genotype, phenotype and inhibition studies [PDF]
, 2023 Complement-mediated kidney diseases are ultrarare conditions characterized by excess complement activation related in most cases to complement gene variants or circulating autoantibodies. These conditions are chronic and can lead to kidney failure.
Aradottir, S.S.
core
Die atheroprotektive Rolle der C5aR2 Defizienz in Apolipoprotein E defizienten Mäusen
, 2017 Published by ...
openaire +2 more sources
补体在主要组织相容性抗原Ⅰ类抗体介导的输血相关急性肺损伤中的作用
Zhongshan Daxue xuebao. Yixue kexue ban目的输血相关急性肺损伤（TRALI）是一种常见的致死性输血不良反应，主要组织相容性抗原（MHC）Ⅰ类抗体是引起TRALI的重要因素，但补体在其发病机制中的作用尚未完全阐明。本研究旨在探索补体在MHC-Ⅰ类抗体介导TRALI中的作用，为临床防治提供理论依据。方法本研究利用“二次打击”理论建立TRALI小鼠模型，首次打击采用脂多糖（LPS），第二次打击采用MHC-Ⅰ类抗体。将雄性Balb/c小鼠随机分为7组，分别命名为Naïve（空白对照）、LPS（仅首次打击）、Isotype（同型抗体对照）、TRALI ...
张泽 +4 more
doaj
Epigenome-wide association study on the plasma metabolome suggests self-regulation of the glycine and serine pathway through DNA methylation [PDF]
Background: The plasma metabolome reflects the physiological state of various biological processes and can serve as a proxy for disease risk. Plasma metabolite variation, influenced by genetic and epigenetic mechanisms, can also affect the cellular ...
Andreu-Sánchez, Sergio +14 more
core +2 more sources
The Great Escape - Investigating Complement Evasion Mechanisms in Pathogenic Bacteria [PDF]
The complement system, a crucial part of the innate immune system, protects the human body during bacterial infections. Complement comprises three pathways, classical, lectin, and alternative, which activate as a protein cascade.
Magda, Michal
core