Results 11 to 20 of about 3,979 (154)
Brain Research BulletinCerebral ischemia-reperfusion injury (CIRI), a prevalent stroke-related complication, can lead to severe brain damage. Inflammation is a crucial factor in CIRI pathogenesis, and the complement component 3a receptor (C3aR) could be a key mediator in the ...
Junyi Tan, Hui Gan
exaly +4 more sources
C3aR plays both sides in regulating resistance to bacterial infections. [PDF]
PLoS Pathogens, 2022 Activation of the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which interacts with membrane-bound receptor C3aR to regulate innate immune cell function and outcome of bacterial infection.
Jesse A Corcoran, Brooke A Napier
doaj +3 more sources
C3a-C3aR signaling is a novel modulator of skeletal homeostasis
Bone Reports, 2023 Osteoimmune studies have identified complement signaling as an important regulator of the skeleton. Specifically, complement anaphylatoxin receptors (i.e., C3aR, C5aR) are expressed on osteoblasts and osteoclasts, implying that C3a and/or C5a may be ...
Megan B. Kuhn +7 more
doaj +2 more sources
Downregulation of complement C3 and C3aR expression in subcutaneous adipose tissue in obese women. [PDF]
PLoS ONE, 2014 The central component of the complement system, C3, is associated with obesity, metabolic syndrome and cardiovascular disease however the underlying reasons are unknown.
Abhishek Gupta +7 more
doaj +2 more sources
Frontiers in Bioscience-Landmark, 2023 Background: Renin-dependent hypertension with tubulointerstitial injury remains a problem with high prevalence in the clinic. However, whether and how renin participates in tubulointerstitial injury remains incompletely understood.
Chongjian Wang +8 more
doaj +2 more sources
Complement C3aR depletion reverses HIF-1α–induced metabolic impairment and enhances microglial response to Aβ pathology [PDF]
The Journal of Clinical Investigation, 2023 Microglia are the major cell type expressing complement C3a receptor (C3aR) in the brain. Using a knockin mouse line in which a Td-tomato reporter is incorporated into the endogenous C3ar1 locus, we identified 2 major subpopulations of microglia with ...
Manasee Gedam +6 more
doaj +2 more sources
The C3-C3aR axis drives rotenone-induced cognitive damage via synaptic engulfment, dark microglia and PANoptosis. [PDF]
Redox BiolCognitive impairment, a common non-motor symptom of Parkinson's disease (PD), is a key factor in reducing the life quality of patients, but its pathogenesis remains unclear.
Liu J +6 more
europepmc +2 more sources
Roles of Microglia in Cerebral Small Vessel Disease. [PDF]
CNS Neurosci TherChronic cerebral hypoperfusion triggers microglial activation in cerebral small vessel disease (CSVD). Activated microglia drive neuroinflammation, oxidative stress, and blood–brain barrier disruption, leading to white matter hyperintensities, enlarged perivascular spaces, and other neuroimaging features.
Jin C +7 more
europepmc +2 more sources
The Role of the C3a-C3aR Pathway in Diseases: Latest Research Advances. [PDF]
Mediators InflammC3a is a key active factor in the complement system, capable of participating in various physiological and pathological processes by binding to its C3a receptor (C3aR).
Bo X, Wang M, Liu Y, Zhong Y.
europepmc +2 more sources
C3aR signaling and gliosis in response to neurodevelopmental damage in the cerebellum
Journal of Neuroinflammation, 2019 Background Conditional ablation of the Smarca5 gene in mice severely impairs the postnatal growth of the cerebellum and causes an ataxic phenotype. Comparative gene expression studies indicated that complement-related proteins were upregulated in the ...
Kevin G. Young +2 more
doaj +2 more sources