Results 11 to 20 of about 5,430 (207)
C3a-C3aR signaling is a novel modulator of skeletal homeostasis
Bone Reports, 2023 Osteoimmune studies have identified complement signaling as an important regulator of the skeleton. Specifically, complement anaphylatoxin receptors (i.e., C3aR, C5aR) are expressed on osteoblasts and osteoclasts, implying that C3a and/or C5a may be ...
Megan B. Kuhn +7 more
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C3aR plays both sides in regulating resistance to bacterial infections.
PLoS Pathogens, 2022 Activation of the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which interacts with membrane-bound receptor C3aR to regulate innate immune cell function and outcome of bacterial infection.
Jesse A Corcoran, Brooke A Napier
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C3aR signaling and gliosis in response to neurodevelopmental damage in the cerebellum [PDF]
Journal of Neuroinflammation, 2019 Background Conditional ablation of the Smarca5 gene in mice severely impairs the postnatal growth of the cerebellum and causes an ataxic phenotype. Comparative gene expression studies indicated that complement-related proteins were upregulated in the ...
Kevin G. Young +2 more
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Virulence, 2019 The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Andreas Klos +2 more
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Fungal Colonization by Malassezia globosa Promotes Breast Cancer Progression and M2 Macrophage Polarization Through the MBL‐C3a–C3aR Signaling Pathway [PDF]
MicrobiologyOpenFungal colonization is a known carcinogenic accomplice in lung and colon cancer but has not been implicated in breast cancer. Here, we attempt to explore the mechanism behind fungal colonization and carcinogenesis by Malassezia globosa in breast cancer ...
Chongwu He +7 more
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Brain Research BulletinCerebral ischemia-reperfusion injury (CIRI), a prevalent stroke-related complication, can lead to severe brain damage. Inflammation is a crucial factor in CIRI pathogenesis, and the complement component 3a receptor (C3aR) could be a key mediator in the ...
Junyi Tan
exaly +3 more sources
Hyperactive Behavior and Altered Brain Morphology in Adult Complement C3a Receptor Deficient Mice
Frontiers in Immunology, 2021 The C3a receptor (C3aR) is a seven trans-membrane domain G-protein coupled receptor with a range of immune modulatory functions. C3aR is activated by the third complement component (C3) activation derived peptide C3a and a neuropeptide TLQP-21.
Andrea Pozo-Rodrigálvarez +8 more
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Monitoring C3aR Expression Using a Floxed tdTomato-C3aR Reporter Knock-in Mouse [PDF]
The Journal of Immunology, 2017 Abstract C3a exerts multiple biologic functions through activation of its cognate C3a receptor. C3−/− and C3aR−/− mice have been instrumental in defining important roles of the C3a/C3aR axis in the regulation of acute and chronic inflammatory diseases, including ischemia/reperfusion injury, allergic asthma, autoimmune nephritis, and ...
Katharina M Quell +15 more
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C3aR inhibition reduces neurodegeneration in experimental lupus [PDF]
Lupus, 2009 Complement activation is an important aspect of systemic lupus erythematosus. In this study we investigated the role of C3a/C3a receptor (R) signaling in brains of the lupus model, MRL/lpr mice, by treating the mice with C3aR antagonist (a) from 13 to 19 weeks of age.
A, Jacob +4 more
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Molecular pharmacology of C3aR modulators [PDF]
, 2017 The complement system plays key roles in both the innate (non-specific) and acquired (specific) immune response. Complement activation is a tightly regulated process, which takes place in a sequential manner by at least three pathways. All of these pathways generate a small anaphylatoxin protein called C3a.
Xaria X. Li +3 more
openaire +5 more sources