Journal of Translational Medicine, 2023 Background Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT).
Danyu You +7 more
doaj +1 more source
IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression
Cell & Bioscience, 2022 Background Major depressive disorder is characterized by not only monoamine neurotransmitters deficiencies but also persistent neuroinflammation. The complement system is an attractive therapeutic target for various inflammation-related diseases due to ...
Man-Man Zhang +11 more
doaj +1 more source
Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]
, 2015 Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
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The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]
, 2018 The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J +4 more
core +1 more source
Potential Mechanisms Underlying TGF-β-mediated Complement Activation in Lung Fibrosis [PDF]
, 2017 While our previous studies suggest that limiting bleomycin-induced complement activation suppresses TGF-β signaling, the specific hierarchical interactions between TGF-β and complement in lung fibrosis are unclear.
Cipolla, Ellyse +5 more
core +2 more sources
Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury [PDF]
, 2010 Background: Activated complement system is known to mediate neuroinflammation and neurodegeneration following exposure to hypoxic-ischemic insults. Therefore, inhibition of the complement activation cascade may represent a potential therapeutic strategy ...
George C. Tsokos +5 more
core +3 more sources
Complement System Part II: Role in Immunity [PDF]
, 2015 International audienceThe complement system has been considered for a long time as a simple lytic cascade, aimed to kill bacteria infecting the host organism.
Fremeaux-Bacchi, Veronique +4 more
core +6 more sources
Deficiency of C3a receptor attenuates the development of diabetic nephropathy
BMJ Open Diabetes Research & Care, 2019 Objective Diabetic nephropathy (DN) is the leading cause of chronic kidney disease and end-stage renal disease. Emerging evidence suggests that complement activation is involved in the pathogenesis of DN.
Ming-hui Zhao +2 more
doaj +1 more source
Magnetostratigraphic, biostratigraphic, and stable isotope stratigraphy of an Upper Miocene drill core from the Salé Briqueterie (northwestern Morocco):... [PDF]
, 1994 We report a high-resolution stable isotope, carbonate, magnetostratigraphic, and biostratigraphic record from a 175-m drill core from the Salé Briqueterie, which is part of the Bou Regreg section in northwestern Morocco.
Benson, Richard H. +4 more
core +2 more sources
79 The Effect of The C3 And C3ar On Adult Hippocampal Neurogenesis [PDF]
British Journal of Surgery, 2021 Abstract Introduction Adult hippocampal neurogenesis (AHN) is the process whereby new neurons are added to the dentate gyrus to support cognition. This process is disrupted in neurological disorders such as mesial temporal lobe epilepsy and there is significant involvement of the complement system ...
O Marei, L Westacott
openaire +1 more source