Results 31 to 40 of about 3,979 (154)

Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion. [PDF]

, 2020
Microglial activation participates in white matter injury after cerebral hypoperfusion. However, the underlying mechanism is unclear. Here, we explore whether activated microglia aggravate white matter injury via complement C3-C3aR pathway after chronic ...
Zhu, Yuan, Pan, Jiaji, Wang, Liping, Tu, Xuanqiang, Venkatesh, Ashwin, Wang, Yongting, Mamtilahun, Muyassar, Yang, Guo-Yuan, Zhang, Zhijun, Jin, Kunlin, Zhang, Lin-Yuan, Shi, Rubing   +11 more
core   +4 more sources

IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression

Cell & Bioscience, 2022
Background Major depressive disorder is characterized by not only monoamine neurotransmitters deficiencies but also persistent neuroinflammation. The complement system is an attractive therapeutic target for various inflammation-related diseases due to ...
Man-Man Zhang, Min-Xia Guo, Qiu-Ping Zhang, Xue-Qin Chen, Na-Zhi Li, Qing Liu, Jie Cheng, Shi-Le Wang, Guang-Hui Xu, Cheng-Fu Li, Ji-Xiao Zhu, Li-Tao Yi   +11 more
doaj   +1 more source

The “C3aR Antagonist” SB290157 is a Partial C5aR2 Agonist

Frontiers in Pharmacology, 2021
Innate immune complement activation generates the C3 and C5 protein cleavage products C3a and C5a, defined classically as anaphylatoxins. C3a activates C3aR, while C5a activates two receptors (C5aR1 and C5aR2) to exert their immunomodulatory activities ...
Xaria X. Li, Vinod Kumar, Richard J. Clark, John D. Lee, Trent M. Woodruff   +4 more
doaj   +1 more source

C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome

Journal of Translational Medicine, 2023
Background Complement component 3a and its receptor (C3a/C3aR) and the nucleotide-binding oligomerization domain-like receptor protein-3 (NLRP3) inflammasome contribute to epithelial-mesenchymal transition (EMT).
Danyu You, Kun Nie, Xiaoting Wu, Mengjie Weng, Liyan Yang, Yi Chen, Jiong Cui, Jianxin Wan   +7 more
doaj   +1 more source

C3a and Its Receptor C3aR Are Detectable in Normal Human Epidermal Keratinocytes and Are Differentially Regulated via TLR3 and LL37

Journal of Innate Immunity, 2021
To study the molecular interplay between TLRs and complement representing ancient danger-sensing mechanisms, we examined the regulation of the C3a/anaphylatoxin C3a receptor (C3aR) axis in normal human epidermal keratinocytes (NHEKs) by treatment with ...
Susanne Mommert, Lisa Doenni, Phillip Szudybill, Christoph Zoeller, Frerk Hinnerk Beyer, Thomas Werfel   +5 more
doaj   +1 more source

C3a Receptor Signaling Inhibits Neurodegeneration Induced by Neonatal Hypoxic-Ischemic Brain Injury

Frontiers in Immunology, 2021
Hypoxic-ischemic neonatal encephalopathy due to perinatal asphyxia is the leading cause of brain injury in newborns. Clinical data suggest that brain inflammation induced by perinatal insults can persist for years.
Andrea Pozo-Rodrigálvarez, YiXian Li, Anna Stokowska, Jingyun Wu, Jingyun Wu, Verena Dehm, Hana Sourkova, Harry Steinbusch, Harry Steinbusch, Carina Mallard, Henrik Hagberg, Henrik Hagberg, Milos Pekny, Marcela Pekna   +13 more
doaj   +1 more source

Summary of C3aR-dependent phenotypes in bacterial infection models.

, 2022
Summary of C3aR-dependent phenotypes in bacterial infection models.
Jesse A. Corcoran (13199685), Brooke A. Napier (13199688)   +1 more
core   +1 more source

Deficiency of C3a receptor attenuates the development of diabetic nephropathy

BMJ Open Diabetes Research & Care, 2019
Objective Diabetic nephropathy (DN) is the leading cause of chronic kidney disease and end-stage renal disease. Emerging evidence suggests that complement activation is involved in the pathogenesis of DN.
Ming-hui Zhao, Xiao-Qian Li, Dong-Yuan Chang   +2 more
doaj   +1 more source

TLQP-21 is a low potency partial C3aR activator on human primary macrophages

Frontiers in Immunology, 2023
TLQP-21 is a 21-amino acid neuropeptide derived from the VGF precursor protein. TLQP-21 is expressed in the nervous system and neuroendocrine glands, and demonstrates pleiotropic roles including regulating metabolism, nociception and microglial functions.
Xaria X. Li, John D. Lee, Han S. Lee, Richard J. Clark, Trent M. Woodruff   +4 more
doaj   +1 more source

Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression

, 2021
Complement has emerged as a component of tumor-promoting inflammation. We conducted a systematic assessment of the role of complement activation and effector pathways in sarcomas.
Reis, Edimara S., Jaillon, Sebastien, Di Marco, S, Mapelli, SN, Magrini, Elena, Magrini, E, Cananzi, F, Cananzi, Ferdinando, Carriero, R, Carriero, Roberta, Lambris, JD, Donato, A, Doni, Andrea, Jaillon, S, Pasqualini, Fabio, Reis, ES, Supino, D, Di Marco, Sabrina, Mapelli, Sarah N., Guevara Lopez, MDLL, Lambris, John D., Garlanda, C, Mantovani, Alberto, Inforzato, Antonio, Perucchini, Chiara, Supino, Domenico, Inforzato, A, Pasqualini, F, Donato, Alessia, Perucchini, C, Ponzetta, Andrea, Guevara Lopez, Maria de la Luz, Peano, Clelia, Doni, A, Peano, C, Ponzetta, A, Colombo, P, Garlanda, Cecilia, Mantovani, A, Colombo, Piergiuseppe   +39 more
core   +1 more source