Results 51 to 60 of about 5,430 (207)

Asparaginyl endopeptidase (Legumain) supports human Th1 induction via cathepsin L-mediated intracellular C3 activation [PDF]

, 2018
Autocrine activation of the complement receptors C3aR and CD46 by complement activation components C3a and C3b produced through C3 cleavage by the protease cathepsin L (CTSL) during T cell stimulation is a requirement for IFN-γ production and Th1 ...
Claudia Kemper, Claudia Kemper, Claudia Kemper, Colin Watts, Erin E. West, John Cardone, Martin V. Kolev, Simon Freeley, Sira C. Günther, Sira C. Günther, Thomas Reinheckel   +10 more
core   +3 more sources

Pharmacological targeting of C3aR modulates mesangial matrix deposition in db/db mice [PDF]

PeerJ
Complement activation significantly contributes to the progression of diabetic kidney disease (DKD). Recent studies have shown that renal levels of the complement component 3 (C3) and its receptor (C3aR) increase with disease progression.
Jing Zheng, Xiaoting Wu, Mengjie Weng, Jianxin Wan, Xiaohong Zhang   +4 more
doaj   +2 more sources

Efficient chemical synthesis of human complement protein C3a [PDF]

, 2013
We report the total chemical synthesis of human C3a by one-pot native chemical ligation of three unprotected peptide segments, followed by efficient in vitro folding that yielded the anaphylatoxin C3a in high yield and excellent purity. Synthetic C3a was
Ames, Artin Ghassemian, Bajic, Bang, Bokisch, Ching-I Anderson Wang, Cianflone, Cook, Daffern, David P. Fairlie, Dawson, Elsner, Huber, Hugli, Kent, Klos, Mei-Kwan Yau, Morales, Mueller-Ortiz, Paques, Paul F. Alewood, Richard J. Lewis, Ricklin, Robert C. Reid, Schnölzer, Scully, Thomas Durek, Wilken   +27 more
core   +1 more source

Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway

Cell Reports, 2023
Summary: Complement activation is thought to underline the pathologic progression of obesity-related metabolic disorders; however, its role in adaptive thermogenesis has scarcely been explored.
Ling-Ran Kong, Xiao-Hui Chen, Qing Sun, Kai-Yuan Zhang, Lian Xu, Liliqiang Ding, Yan-Ping Zhou, Ze-Bei Zhang, Jing-Rong Lin, Ping-Jin Gao   +9 more
doaj   +1 more source

Downsizing a human inflammatory protein to a small molecule with equal potency and functionality [PDF]

, 2013
A significant challenge in chemistry is to rationally reproduce the functional potency of a protein in a small molecule, which is cheaper to manufacture, non-immunogenic, and also both stable and bioavailable.
A Ghassemian, A Jacob, A Sonesson, AS Kirshenbaum, BL Wu, BN Bullock, CC Scully, D Seebach, DP Fairlie, EB Grant, F Denonne, F Denonne, G Bajic, G Ruiz-Gomez, H Takematsu, H Yin, H-C Wilken, J Kildsgaard, J Lim, J Venkatraman, JA Ember, JDA Tyndall, JM Scholtz, JZ Sun, KD Stigers, L Dreier, LM Proctor, M Pasupuleti, MN Munkonda, N Mizutani, NP Gerard, P Hutamekalin, P-J Haas, PF Zipfel, R Huber, RS Ames, SL Masters, TE Hugli, TE Hugli, TH Chao, VA Bokisch, WF DeGrado, Y Fukuoka, Y Mamane, Z Tang   +44 more
core   +1 more source

Complement in the homeostatic and ischemic brain [PDF]

, 2015
The complement system is a component of the immune system involved in both recognition and response to pathogens, and it is implicated in an increasing number of homeostatic and disease processes. It is well documented that reperfusion of ischemic tissue
Aivazian, Akita, Alexander, Amara, Arumugam, Atkinson, Austen, Barber, Barber, Bednar, Beek, Bellander, Benard, Benard, Benoit, Boos, Busche, Carmichael, Carmichael, Carmichael, Cavusoglu, Cervera, Chu, Cojocaru, Costa, Cowell, Crane, Cudrici, Davoust, De La Rosa, De Simoni, De Simoni, Di Napoli, Ducruet, Ducruet, Ducruet, Ducruet, Elvington, Elvington, Engstrom, Figueroa, Fisher, Frauenknecht, Garrett, Gasque, Gasque, Gesuete, Gill, Harboe, Harhausen, Heese, Heimann, Hoke, Holers, Huang, Huber-Lang, Hurtado, Iadecola, Imm, Jauneau, Katzan, Kim, Kramer, Kulik, Levi-Strauss, Lew, Li, Li, Lindsberg, Luo, Mack, McMullen, Mead, Mehta, Mocco, Mocco, Mocco, Moriyama, Morrison, Mukherjee, Mukherjee, Murphy, Olsson, Orsini, Osaka, Osthoff, Patel, Pavlovski, Pedersen, Pedersen, Pedersen, Persson, Pisalyaput, Rahpeymai, Ramaglia, Ricklin, Rogers, Rupprecht, Rynkowski, Schafer, Schafer, Schultz, Shinjyo, Soane, Somani, Speidl, Stahel, Stephan, Stevens, Stokowska, Stokowska, Storini, Széplaki, Ten, Ten, Thundyil, Thurman, Tohgi, Van Beek, Vasthare, Wieloch, Williams, Yang, Zee, Zhang, Zhang, Zhang, Zhang, Zhang, Zipfel   +129 more
core   +3 more sources

Complement C3aR depletion reverses HIF-1α–induced metabolic impairment and enhances microglial response to Aβ pathology

The Journal of Clinical Investigation, 2023
Microglia are the major cell type expressing complement C3a receptor (C3aR) in the brain. Using a knockin mouse line in which a Td-tomato reporter is incorporated into the endogenous C3ar1 locus, we identified 2 major subpopulations of microglia with ...
Manasee Gedam, Michele M. Comerota, Nicholas E. Propson, Tao Chen, Feng Jin, Meng C. Wang, Hui Zheng   +6 more
doaj   +1 more source

C3a/C3aR Affects the Propagation of Cryptosporidium parvum in the Ileum Tissues of Mice by Regulating the Gut Barrier, Cell Proliferation, and CD4⁺ T Cell Main Effectors

Animals, 2023
Cryptosporidium parvum is an important zoonotic protozoon that threatens the health of humans and animals, but the interaction mechanisms between C. parvum and hosts are poorly understood.
Xin Yang, Xuemei Wu, Shuang Huang, Qian Yao, Xi Chen, Junke Song, Yingying Fan, Guanghui Zhao   +7 more
doaj   +1 more source

A C3(H20) recycling pathway is a component of the intracellular complement system [PDF]

, 2017
An intracellular complement system (ICS) has recently been described in immune and nonimmune human cells. This system can be activated in a convertase-independent manner from intracellular stores of the complement component C3. The source of these stores
Botto, Bu, Hrishikesh S. Kulkarni, John P. Atkinson, Liszewski, M. Kathryn Liszewski, Michelle Elvington, Nickells, Paula Bertram, Seya, Singer, Vĕtvicka   +11 more
core   +2 more sources

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling. [PDF]

, 2016
The complement cascade is comprised of a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue injury. The complement activation peptide, C5a, binds two seven transmembrane receptors, namely
Blaskovich, M.A., Clark, R.J., Cooper, M.A., Croker, D.E., Floudas, C.A., Halai, R., Kaeslin, G., Monk, P.N., Morikis, D., Schofield, Z., Woodruff, T.M., Wu, M.C.   +11 more
core   +1 more source