Results 51 to 60 of about 3,979 (154)

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

Role of C3aR phosphorylation on β-arrestin-2 recruitment.

, 2013
(A) HEK-293 cells transiently transfected with Flag-βarrestin-2 and HA-tagged WT-C3aR, or indicated C3aR mutants were exposed to buffer or C3a (100 nM) for 5 min.
Andreas Klos (71279), Hydar Ali (292814), Kshitij Gupta (292813), Hariharan Subramanian (292812)   +3 more
core   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages.

PLoS Pathogens, 2022
The fungal pathogen Histoplasma capsulatum (Hc) invades, replicates within, and destroys macrophages. To interrogate the molecular mechanisms underlying this interaction, we conducted a host-directed CRISPR-Cas9 screen and identified 361 genes that ...
Allison Cohen, Edwin E Jeng, Mark Voorhies, Jane Symington, Nebat Ali, Rosa A Rodriguez, Michael C Bassik, Anita Sil   +7 more
doaj   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Immunofluorescent analysis of C3a and C3aR expression in kidney of different groups.

, 2014
(A) IF staining for C3a and double-IF staining of C3aR with CD31 (scale bar = 50 µm).
Ling Li (38566), Hongping Zhu (665769), Qinghua Yin (665767), Shenju Gou (665768), Jie Zhang (64655), Ping Fu (273326), Xi Tang (453596), Jingqiu Cheng (381790), Lin Bai (338207), Fang Liu (13271)   +9 more
core   +1 more source

Retinal Injury Activates Complement Expression in Müller Cells Leading to Neuroinflammation and Photoreceptor Cell Death

Cells, 2023
Retinal detachment (RD) is a neurodegenerative blinding disease caused by plethora of clinical conditions. RD is characterized by the physical separation of retina from the underlying retinal pigment epithelium (RPE), eventually leading to photoreceptor ...
Steven J. Tabor, Kentaro Yuda, Jonathan Deck, Gopalan Gnanaguru, Kip M. Connor   +4 more
doaj   +1 more source

Downcurrent variation in submarine channel‐fill architecture from the shelf to upper slope

Sedimentology, EarlyView.
ABSTRACT The transition between the shelf and the upper slope is often considered an area of sediment bypass, where steeper gradients increase flow velocities and maintain particles in suspension. In addition to transferring sediments into deeper basins, upper‐slope areas can also host channelised submarine deposits.
Moreno Pizzutto, Fabrizio Felletti, Adam McArthur, Mattia Marini, George Pantopoulos, Daniele Invernizzi, Chiara Zuffetti   +6 more
wiley   +1 more source

MOESM1 of C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts

, 2020
Additional file 1: Table S1. Listing of primers used in this study. Figure S1. Breast cancer development in C3aR deficient mice. a 4 T1 cells were orthotopically injected into WT or C3aR−/− mice.
Jianbao Gao (8295552), Bo Zhu (118038), Fei Yang (46361), Haixia Long (556765), Chi Shu (6818204), Xinxin Wang (134010), Chunyan Hu (324514), Haoran Zha (8295549), Bo Guo (1559695), Li Zhou (54356)   +9 more
core   +1 more source

Structural insights into small-molecule agonist recognition and activation of complement receptor C3aR

The EMBO Journal
The complement system plays crucial roles in innate immunity and inflammatory responses. The anaphylatoxin C3a mediates pro-inflammatory and chemotactic functions through the G protein-coupled receptor C3aR.
Jinuk Kim, Saebom Ko, Chulwon Choi, Jungnam Bae, Hyeonsung Byeon, Chaok Seok, Hee-Jung Choi   +6 more
doaj   +1 more source