Results 71 to 80 of about 3,979 (154)

Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis [PDF]

, 2016
Complement activation, an integral arm of innate immunity, may be the critical link to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Whereas we have previously reported elevated anaphylatoxinscomplement component 3a (C3a) and complement ...
Duerson, Frank, III, Twigg, Homer L., III, Twigg, Homer L., Ragini Vittal, Oscar W. Cummings, Hongmei Gu, Amanda J. Fisher, Duerson, Frank, David S. Wilkes, Fisher, Amanda J., Homer L. Twigg, Peters‐golden, Marc, Mickler, Elizabeth A., Elizabeth A. Mickler, Woodruff, Trent M., Wilkes, David S., Cummings, Oscar W., Marc Peters‐Golden, Trent M. Woodruff, Gu, Hongmei, Peters-Golden, Marc, Vittal, Ragini, Frank Duerson   +22 more
core   +1 more source

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Microglial functions arise from dynamic, context‐dependent programs rather than fixed M1/M2 phenotypes. 2. Inflammatory, interferon‐responsive, phagocytic/lipid‐metabolic and repair‐associated programs coexist across disease stages and brain regions. 3.
Jie Chen, Wangzheqi Zhang, Lizhou Song, Yan Liao, Haoling Zhang, Yiyang Xia, Derong Cui   +6 more
wiley   +1 more source

Young Adult Microglial Deletion of C1q Reduces Engulfment of Synapses and Partially Mitigates Cognitive Impairment in an Aggressive Alzheimer's Disease Mouse Model

Glia, Volume 74, Issue 9, September 2026.
Young adult deletion of microglial C1q reduced engulfment of Vglut1+ synapses and mitigated spatial cognitive deficits at 10 months of age in the amyloidopathy Arctic mouse model of AD. Neither fibrillar amyloid plaques nor soluble or insoluble Aβ levels in the hippocampus were affected by young adult microglial loss of C1q despite reduced phagocytosis
Tiffany J. Petrisko, Shu‐Hui Chu, Angela Gomez‐Arboledas, Blossom Zhang, Andrea J. Tenner   +4 more
wiley   +1 more source

Complement Activation by Post‐Translationally Modified Proteins: Links to Chronic Inflammation and Autoimmunity

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT Post‐translational modifications (PTMs) of proteins are essential to maintain homeostasis as many cellular processes rely on reversible PTMs. However, several PTMs, particularly irreversible PTMs in the extracellular space, can contribute to tissue dysfunction, inflammation, and may even trigger the development of autoimmunity against PTM ...
Marleen M. J. van Greevenbroek, Leendert A. Trouw   +1 more
wiley   +1 more source

Alleviation of the liver injuries in mice after treatment with C3aR antagonist.

, 2013
(A–F) C3aR antagonist group mice displayed reduced liver damage (A–B, D–E) and decreased C3 deposition (C, F) 8 hours after LPS/D-GalN injection. (G–H) C3aR mRNA expression decreased at 8 hours compared with that of the saline group, whereas C5aR mRNA ...
Jingya Hu (340781), Guangyu Zhao (180047), Fei Yang (46361), Hong Yu (6528), Guilian Xu (121291), Stephen Tomlinson (326499), Yusen Zhou (36053), Yan Guo (83742), Hongbin Song (340782), Yu Chen (29959), Fei Qiao (198706), Junfeng Li (340780), Zhongping Duan (304742), Xiaojun Zhou (16139), Shihui Sun (180042), Yuzhang Wu (143824)   +15 more
core   +1 more source

Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation. [PDF]

PLoS ONE, 2016
Adipocytes are differentiated by various transcriptional cascades integrated on the master regulator, Pparγ. To discover new genes involved in adipocyte differentiation, preadipocytes were treated with three newly identified pro-adipogenic small ...
No-Joon Song, Suji Kim, Byung-Hyun Jang, Seo-Hyuk Chang, Ui Jeong Yun, Ki-Moon Park, Hironori Waki, Dean Y Li, Peter Tontonoz, Kye Won Park   +9 more
doaj   +1 more source

C3aR is robustly expressed on the surface of CD3+ cells in the ischemic region.

, 2012
C3aR is not expressed on cells in the SVZ at 24 hours post-MCAO. Immunostaining of the SVZ at 24 hours and 7 days post-MCAO reveals several migrating neuroblasts (DCx+, green) without any significant C3aR immunopositivity (red) (A).
Andrew F. Ducruet (156616), Sergey A. Sosunov (156622), Paul R. Gigante (156626), Marc L. Otten (156633), Paulina Sergot (156641), Zachary L. Hickman (156639), Justin W. Gorski (156631), Richard Y. Hwang (156635), Mason L. Yeh (156628), Peter A. DeRosa (156637), E. Sander Connolly Jr (156644), Brad E. Zacharia (156618)   +11 more
core   +1 more source

The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis. [PDF]

PLoS ONE, 2018
The anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides are autoimmune diseases associated with significant morbidity and mortality. They often affect the kidney causing rapidly progressive glomerulonephritis.
Jonathan Dick, Poh-Yi Gan, A Richard Kitching, Stephen R Holdsworth   +3 more
doaj   +1 more source

Animal models of idiopathic membranous nephropathy: Recent advances and future perspectives

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1325-1337, July 2026.
This review focuses on the evolution of idiopathic membranous nephropathy (IMN) animal models from traditional approaches (Heymann nephritis, C‐BSA, APA) to antigen‐specific models (PLA2R, THSD7A), critically evaluating their advances and limitations in replicating human IMN pathology.
Qiuying Liu, Huixian Bian, Jianhua Liu, Lina Wu, Zhijie Zhang, Hongli Zhao, Xiaosong Qin   +6 more
wiley   +1 more source

Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum

, 2008
International audienceThere is now strong evidence for non-immune or inflammatory functions of complement, notably in the central nervous system. In particular, it has been recently reported that the anaphylatoxin receptors C3aR and C5aR are transiently ...
Benard, Magalie, Fontaine, Marc, Vaudry, David, Vaudry, Hubert, Galas, Ludovic, Leprince, Jérôme, Raoult, Emilie, Falluel-Morel, Anthony, Gonzalez, Bruno, J.   +8 more
core   +1 more source