Results 81 to 90 of about 3,979 (154)
Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?
European Journal of Immunology, Volume 56, Issue 7, July 2026.Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni +4 more
wiley +1 more source
Schematic of C3aR-dependent innate immune cell function during bacterial infections.
, 2022 Schematic of C3aR-dependent innate immune cell function during bacterial infections.
Jesse A. Corcoran (13199685) +1 more
core +1 more source
The Influence of Anti-C3aR and Anti-C5aR Antibody Levels on the Course of Specific Glomerulonephritis Types. [PDF]
J Clin MedBackground: The complement system factors’ role in the pathogenesis of autoimmunological diseases is known, but the influence of autoantibodies against complement factors’ receptors on the course of specific glomerular diseases remains ...
Szymczak M +9 more
europepmc +2 more sources
Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi +13 more
wiley +1 more source
Real-time PCR for (A) C3aR and (B) collagen I expression in HRGECs.
, 2014 (C) Western blotting for C3aR and collagen I in HRGECs.
Ling Li (38566) +9 more
core +1 more source
Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions
MedComm, Volume 7, Issue 7, July 2026.Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An +4 more
wiley +1 more source
C3aR signaling is required for adipogenic potential of Cfd overexpressing cells.
, 2016 (A) The increased adipogenic potential of Cfd expressing cells is blocked by silencing C3aR expression. Control empty vector (pBp) or Cfd stably overexpressing 3T3-L1 cells (pBp- Cfd) were transiently transfected with siRNAs targeting C3aR and ...
Ui Jeong Yun (3111426) +9 more
core +1 more source
Knockdown of NHERF1 and NHERF2 does not affect C3aR internalization.
, 2013 (A) shRNA control HMC-1 cells (B) NHERF1 knockdown (KD) and (C) NHERF2 KD cells were exposed to buffer or C3a (100 nM) for 5 min. Cells were washed with ice-cold FACS buffer, incubated with a mouse anti-C3aR antibody or an isotype control antibody ...
Hydar Ali (292814) +2 more
core +1 more source
Di-san junyi daxue xuebao, 2019 Objective To investigate the effect of astrocyte-microglia crosstalk mediated by complement C3/C3aR signaling on hydrocephalus after germinal matrix hemorrhage (GMH) in newborn rats.
GENG Junjun +4 more
doaj +1 more source
Cytokine profile of C3ar-/- vs. WT BALB/c and B6 mice in DSS colitis.
, 2013 Cytokine levels were measured in tissue homogenates using a bead-based immunoassay. The data shown are means ± SEM from n = 3 (WT, H2O), n = 10 (WT, DSS), n = 5 (C3ar-/-, H2O), and n = 11 (C3ar-/-, DSS) mice for BALB/c, and n = 6 (WT, H2O), n = 10 (WT ...
André Bleich (2201215) +6 more
core +1 more source