Immunobiology, 2022 The relationship between C3a-C3aR, IL-1β, and the acute exacerbation of chronic obstructive pulmonary disease is still unclear. This study aims to explore the expression levels of C3aR in peripheral blood WBCs and the concentrations of C3a, C3aR, and IL-1β in plasma in healthy controls and patients with chronic obstructive pulmonary disease (COPD).WBCs
Zhu, Li +6 more
openaire +2 more sources
Structural insights into the agonist activity of the nonpeptide modulator JR14a on C3aR. [PDF]
Cell DiscovLuo P +14 more
europepmc +4 more sources
Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis [PDF]
, 2011 Injury and inflammation are potent regulators of adult neurogenesis. As the complement system forms a key immune pathway that may also exert critical functions in neural development and neurodegeneration, we asked if complement receptors regulate ...
Britschgi, Markus +9 more
core +2 more sources
Immune Predictors of Radiotherapy Outcomes in Cervical Cancer
Advanced Science, Volume 13, Issue 16, 18 March 2026.This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang +8 more
wiley +1 more source
Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation. [PDF]
PLoS ONE, 2016 Adipocytes are differentiated by various transcriptional cascades integrated on the master regulator, Pparγ. To discover new genes involved in adipocyte differentiation, preadipocytes were treated with three newly identified pro-adipogenic small ...
No-Joon Song +9 more
doaj +1 more source
Female‐biased astrocytic priming shapes early locus coeruleus vulnerability in an Aβ oligomer milieu
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION The locus coeruleus (LC) is an early site of Alzheimer's disease (AD) pathology, yet the role of brainstem astrocytes in early, sex‐dependent vulnerability remains unclear. METHODS In 2‐ to 3‐month‐old APP/PS1 mice, we combined in vivo proton magnetic resonance spectroscopy (MRS) of the brainstem with region‐resolved molecular ...
Srishti Kushwaha +4 more
wiley +1 more source
Correction to: the role of the complement system in traumatic brain injury: a review [PDF]
, 2018 After publication of the article [1], it was brought to our attention that Tables 1 and 2 were missing from the final manuscript, These tables can be seen below and have now been added to the revised version of the ...
Hammad, Adnan +2 more
core +1 more source
The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis. [PDF]
PLoS ONE, 2018 The anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides are autoimmune diseases associated with significant morbidity and mortality. They often affect the kidney causing rapidly progressive glomerulonephritis.
Jonathan Dick +3 more
doaj +1 more source
Innate immunity and neuroinflammation [PDF]
, 2013 Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core +3 more sources
A revised chronostratigraphic framework for International Ocean Discovery Program Expedition 355 sites in Laxmi Basin, eastern Arabian Sea [PDF]
, 2020 International Ocean Discovery Program Expedition 355 drilled Sites U1456 and U1457 in Laxmi Basin (eastern Arabian Sea) to document the impact of the South Asian monsoon on weathering and erosion of the Himalaya.
Griffith, Elizabeth M +7 more
core +2 more sources