Results 91 to 100 of about 5,430 (207)
Hypoxia in human NT2-N neurons : The role of acidosis, mitochondria and inflammation [PDF]
, 2008 Approximately 4 million infants out of 130 million worldwide annual births suffer from birth asphyxia. Of these, approximately 25% die and 25% develop some kind of neurological sequelae (UNICEF 2003).
Frøyland, Elisabeth
core +1 more source
Epilepsia, Volume 67, Issue 2, Page 908-922, February 2026.Abstract Objective Accumulating evidence indicates that aberrant C1q‐C3 complement signaling in microglia and astrocytes drives synaptic dysfunction and neuronal loss. C1q‐mediated synaptic dysfunction disrupts neuronal circuitry balance and can lead to network hyperexcitability in epilepsy.
Yoonyi Jeong +5 more
wiley +1 more source
Scientific Reports, 2023 The spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can interact with endothelial cells. However, no studies demonstrated the direct effect of the spike protein subunit 1 (S1) in inducing lung vascular damage and the ...
Luca Perico +8 more
doaj +1 more source
Palaeomagnetic chronology of the evaporitic sedimentation in the Neogene Fortuna Basin (SE Spain): early restriction preceding the 'Messinian Salinity Crisis' [PDF]
, 1999 The magnetostratigraphic study of the evaporitic Río Chicamo section (240 m) in the Neogene Fortuna Basin (Murcia, southeast Spain) has identified the record of five magnetozones.
Dinarès-Turell, Jaume +3 more
core +1 more source
The FASEB Journal, 2016 ABSTRACT Complement activation, an integral arm of innate immunity, may be the critical link to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Whereas we have previously reported elevated anaphylatoxins—complement component 3a (C3a) and complement component 5a (C5a)—in IPF, which interact with TGF‐β and ...
Gu, Hongmei +9 more
openaire +6 more sources
Rodent models of complement activation-related pseudoallergy: Inducers, symptoms, inhibitors and reaction mechanisms [PDF]
, 2015 Complement activation-related pseudoallergy (CARPA) is a hypersensitivity reaction to intravenous administration of nanoparticle-containing medicines (nanomedicines).
Dézsi, László +4 more
core +1 more source
Advanced Science, Volume 13, Issue 3, 14 January 2026.Alzheimer's disease (AD) is the most common neurodegenerative disorder. This study demonstrates that microglial Rack1 deficiency decreased Aβ deposition and neuroinflammation and ameliorated cognitive impairments in AD model mice by enhancing IGF1‐mediated astrocytic phagocytosis.
Jingdan Zhang +13 more
wiley +1 more source
Human Mutation, Volume 2026, Issue 1, 2026.Lung cancer (LC) patients frequently develop infectious pneumonia, often leading to suspension of anticancer therapy, yet the impact of LC on pneumonia progression remains unclear. This study employed a multidimensional approach to investigate whether LC constitutes a critical factor contributing to pulmonary infection onset and adverse short‐term ...
Yi-Fei Diao +8 more
wiley +1 more source
Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Sbcutaneous Adipose Tissue and Adipocytes in Acquired Obesity [PDF]
, 2017 Inflammation is an important mediator of obesity-related complications such as the metabolic syndrome but its causes and mechanisms are unknown. As the complement system is a key mediator of inflammation, we studied whether it is activated in acquired ...
Hakkarainen, Antti +14 more
core +1 more source
An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. [PDF]
, 2015 Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells.
Fishbein, MC +7 more
core +1 more source