Results 91 to 100 of about 3,979 (154)

Effect of DAF on interaction of C3a and C3aR in lungs of rats after BOP exposure.

, 2018
Representative micro-photos of C3a-C3aR interaction in lungs of frozen sections stained with anti-C3a and anti-C3aR antibodies. Original magnification = 400×, and scale bar = 100μm. n = 8 for all the groups except 48 h experimental samples (n = 5).
Bin Liu (5899), Yansong Li (673208), Milomir O. Simovic (5675969), Mikulas Chavko (3372812), Olawale A. Aderemi (5675966), Zhangsheng Yang (371888), Michael A. Dubick (5165798), Leopoldo C. Cancio (5165789)   +7 more
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The Complement C3a–C3aR Axis Promotes Development of Thoracic Aortic Dissection via Regulation of MMP2 Expression

, 2018
Thoracic aortic dissection (TAD), once ruptured, is devastating to patients, and no effective pharmaceutical therapy is available. Anaphylatoxins released by complement activation are involved in a variety of diseases. However, the role of the complement
Xuerui Wang, Lixin Jia, Chang Liu, Feng Lan, Yuan Wang, Nan Dai, Yan Liu, Hongjia Zhang, Weihong Ren, Youcai Ma, Jie Du, Wen-chao Song, Boya Chen, Shuai Zheng, Wenjian Jiang, Shulan Qiu, Chunmei Piao   +16 more
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Knockdown of β-arrestin-2, but not β-arrestin-1, inhibits agonist-induced C3aR internalization.

, 2013
(A) shRNA control HMC-1 cells (B) β-arrestin-1 KD and (C) β-arrestin-2 KD cells were exposed to buffer (−C3a) or C3a (100 nM) for 5 min. Cells were washed with ice-cold FACS buffer, incubated with a mouse anti-C3aR antibody or an isotype control antibody
Hydar Ali (292814), Kshitij Gupta (292813), Hariharan Subramanian (292812), Arpana Vibhuti (351809), Qiang Guo (218747)   +4 more
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Einfluss der Anaphylatoxinrezeptoren C3aR und C5aR2 auf Bluthochdruck und hypertensive Endorganschäden

, 2022
Bluthochdruck und die daraus resultierenden Endorganschäden stellen, epidemiologisch gesehen, das höchste Gesundheitsrisiko für die Bevölkerung dar (GBD 2016, 2017; Mills et al., 2020).
Bode, Marlies
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Complement C3/C3aR signaling pathway inhibition ameliorates retinal damage in experimental retinal vein occlusion

PURPOSE: Retinal vein occlusion (RVO) is a common retinal vascular disease that severely threatens visual function. This study aims to elucidate the role of the complement C3/C3aR signaling pathway in a laser-induced RVO mouse model and to explore its ...
Xu, Heping, Zhou, Yufan, Zhao, Yanying, Liu, Hengwei, Chen, Zhongping, Guo, Tingting, Ge, Zhengwei, Chen, Juan   +7 more
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Macroscopic findings in C3ar^-/- vs. WT BALB/c and B6 mice in DSS colitis.

, 2013
To account for individual variations in body size, colon length and mLN weight were calculated relative to the body weight for each mouse. A, Colon shortening. To compare DSS-treated WT and C3ar-/- mice, the mean colon length from the H2O-treated control
André Bleich (2201215), Andreas Klos (71279), Silke Glage (108551), Robert Laudeley (297397), Rick A. Wetsel (110801), Elisabeth Wende (407481), Eva Bleich (407482)   +6 more
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Regulation of mRNA expression in C3ar^-/- vs. WT BALB/c and B6 mice in DSS colitis.

, 2013
RNA was isolated from colon tissue homogenates, and mRNA levels were measured by quantitative real time PCR and normalized to the expression of the housekeeping gene Hprt-1.
André Bleich (2201215), Andreas Klos (71279), Silke Glage (108551), Robert Laudeley (297397), Rick A. Wetsel (110801), Elisabeth Wende (407481), Eva Bleich (407482)   +6 more
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Characterizing the Role of the Complement Receptor C3aR in Regulating Inflammatory Responses and Mitochondrial Function in Activated Macrophages

The complement system is an integral part of the innate immune response, and consists of a series of proteins that are mostly (although not exclusively) synthesized in the liver that circulate in the plasma as inactive precursors, as well as receptors on
Corcoran, Jesse Alan
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Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis

, 2018
Background: Platelets have distinct roles in the vascular system in that they are the major mediator of thrombosis, critical for restoration of tissue integrity, and players in vascular inflammatory conditions.
Reis, Edimara S., Sven G. Meuth, Borst, Oliver, Edlich, Frank, Langer, Harald F., Münzer, Patrick, Geisler, Tobias, Edimara S. Reis, Madlung, Johannes, Meuth, Sven G., Sauter, Reinhard J., Gawaz, Meinrad, Maximilian Mauler, Reinhard J. Sauter, Peter Kraft, Frederic N. Emschermann, Emschermann, Frederic N., Ebenhoech, Sonja, Rheinlaender, Johannes, Tilman E. Schäffer, Sauter, Manuela, Lambris, John D., Johannes Madlung, Harald F. Langer, Kleinschnitz, Christoph, Tobias Geisler, Meinrad Gawaz, Henry Nording, Christoph Kleinschnitz, Manuela Sauter, John D. Lambris, Daniel Duerschmied, Frank Edlich, Johannes Rheinlaender, Kraft, Peter, Patrick Münzer, Schäffer, Tilman E., Oliver Borst, Mauler, Maximilian, Dürschmied, Daniel, Nording, Henry, Sonja Ebenhöch   +41 more
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Complement C3aR loss drives colorectal cancer by modulating gut microbiota

, 2020
Several lines of evidence suggest that inflammation plays a pivotal role in the development and progression of colorectal cancer (CRC) and can be unleashed by the loss of innate immunosurveillance. The complement system is a central component of immunity
Silvia Guglietta, Maria Rescigno, Abbass Darwich, Bruno Fosso, Mark D Robinson, Graziano Pesole, Carsten Krieg, Sara Carloni, Lukas M Weber   +8 more
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