Results 101 to 110 of about 5,430 (207)

Complement meets Tau: Exploring the effects of a novel C3‐targeting siRNA in a Tauopathy mouse model

Alzheimer's &Dementia, Volume 21, Issue S7, December 2025.
Abstract Background Complement C3 is a potential therapeutic target in AD. Tau P301S (PS19) mice have emerged as a powerful tool in studying tau pathology. Complement C3aR has been shown to be critical in mediating immune homeostasis and tau pathology in this model, while C3 deficiency mitigated neurodegeneration and neuronal loss.
Maria‐Tzousi Papavergi, Salome Funes, Tara Barbour, Yan Li, David Eyerman, Cynthia A Lemere   +5 more
wiley   +1 more source

The role of the complement system in traumatic brain injury: a review [PDF]

, 2018
Traumatic brain injury (TBI) is an important cause of disability and mortality in the western world. While the initial injury sustained results in damage, it is the subsequent secondary cascade that is thought to be the significant determinant of ...
A Alawieh, A Jauneau, A Kumar, Adnan Hammad, AG Therien, AH Stephan, AI Faden, AL Vescovi, B Oderfeld-Nowak, B Stevens, B-M Bellander, B-M Bellander, B-M Bellander, BJ Gabbe, BP Morgan, BP Morgan, C Cudrici, C Wang, CA Colton, CG Cochrane, D Cederberg, D Dupret, D Ricklin, D Shlosberg, DG Nicholls, DL Sewell, DN Abrous, DP Ankeny, DP Schafer, DT Fearon, E Makou, ED Ponomarev, EO Samstad, F Orsini, F Qiao, FH Brennan, G Arbore, G Winocur, GM Pasinetti, GT Manley, H Osaka, HD Manthey, HG Rus, HG Rus, HX Nguyen, I Leinhase, I Leinhase, I Leinhase, IP Karve, J Rogers, J van Beek, J van Beek, J Wetherington, JJ Ramirez, JL Cole, JR Dunkelberger, K Fluiter, K Färber, K Heese, K Järlestedt, K Pisalyaput, KA Kigerl, L Berliocchi, L Boos, L Longhi, L Longhi, L Soane, Laura Westacott, LG Coulthard, M Bénard, M Bénard, M Fosbrink, M Lévi-Strauss, M Moriyama, M Rancan, M-C Mathieu, Malik Zaben, MC Carroll, MC Carroll, MC Garrett, MD Saxe, ME Benoit, ME Medof, MJ Rutkowski, MK Liszewski, ML Pearn, MM Ruseva, N Sanai, N Shinjyo, NA Martin, O Butovsky, P Gasque, PF Stahel, PF Stahel, PF Stahel, PF Stahel, PH Yager, Q Shi, R Beschorner, R Knoth, RM Chesnut, RM Ransohoff, RS Ames, S Fumagalli, S Nataf, S Nataf, S Yang, SH Weerth, SK Ludwin, SL Kaczorowski, T Fujita, T Kossmann, TA Rupprecht, TJ Shors, U Amara, VM Holers, W Zheng, WH Kwan, X de la Rosa, X Jin, Y Chu, Y Rahpeymai, Y Xiong, YR Bogestål, Z You   +124 more
core   +1 more source

Cellular Communication Networks Mediated by Microglia in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
After ischemic stroke, microglia serve as central regulators within the neuroimmune network, engaging in dynamic crosstalk with neurons, astrocytes, vascular endothelial cells, and peripheral immune cells. By releasing cytokines, chemokines, extracellular vesicles, and transmitting mechanical signals, activated microglia coordinate inflammatory ...
Feiyu Ma, Yi Bai, Na Li, Xiangyu Cai, Ruicong Xu, Xiang Cao   +5 more
wiley   +1 more source

Isomer Dependence in the Assembly and Lability of Silver(I) Trifluoromethanesulfonate Complexes of the Heteroditopic Ligands, 2-, 3-, and 4-[Di(1\u3cem\u3eH\u3c/em\u3e-pyrazolyl)methyl]phenyl(di-\u3cem\u3ep\u3c/em\u3e-tolyl)phosphine [PDF]

, 2014
Three isomers of a new heteroditopic ligand that contains a di(1H-pyrazolyl)methyl (−CHpz2) moiety connected to a di(p-tolyl)phosphine group via a para-, meta-, or ortho-phenylene spacer (pL, mL, and oL, respectively) have been synthesized by using a ...
Gardinier, James R., Hewage, Jeewantha S., Lindeman, Sergey V.   +2 more
core   +1 more source

CD Molecules Nomenclature 2025: Antibody Validation and Expression Profiling of Immune System G Protein‐Coupled Receptors

European Journal of Immunology, Volume 55, Issue 12, December 2025.
HLDA Workshops were established 40 years ago to develop a standardized CD molecule nomenclature for leukocyte cell‐surface molecules by comparing monoclonal antibodies (mAbs) produced by different laboratories and companies. The HLDA11 Workshop focused on validating G‐protein‐coupled receptors (GPCRs) targeting mAbs and assessing cell‐type‐specific ...
Javier Fernández‐Calles, Daniela Kužílková, Fanny Hedin, Violeta Bakardjieva‐Mihaylova, Karolina Škvárová Kramarzová, Menno C. van Zelm, Antonio Cosma, Tomas Kalina, Pablo Engel, the Human Cell Differentiation Molecules (HCDM) organization   +9 more
wiley   +1 more source

Inhibition of complement C3/C3aR alleviates hydrocephalus following germinal matrix hemorrhage in neonatal rats

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of astrocyte-microglia crosstalk mediated by complement C3/C3aR signaling on hydrocephalus after germinal matrix hemorrhage (GMH) in newborn rats.
GENG Junjun, TANG Jun, WANG Lili, TAN Qiang, ZHANG Jianbo   +4 more
doaj   +1 more source

Molecular mechanisms of inflammation and tissue injury after major trauma-is complement the "bad guy"? [PDF]

, 2011
Trauma represents the leading cause of death among young people in industrialized countries. Recent clinical and experimental studies have brought increasing evidence for activation of the innate immune system in contributing to the pathogenesis of ...
Miriam D Neher, Sebastian Weckbach, Michael A Flierl, Markus S Huber-Lang, Philip F Stahel   +4 more
core   +2 more sources

The C3-C3aR axis modulates trained immunity in alveolar macrophages

Immunobiology
Abstract Complement protein C3 is crucial for immune responses in mucosal sites such as the lung, where it aids in microbe elimination and enhances inflammation. While trained immunity – enhanced secondary responses of innate immune cells after prior exposure – is well-studied, the role of the complement system in trained immune ...
Alexander P. Earhart, Rafael Aponte Alburquerque, Marick Starick, Aasritha Nallapu, Lorena Garnica, Ayse Naz Ozanturk, Rahul Kumar Maurya, Xiaobo Wu, Jeffrey A. Haspel, Hrishikesh S. Kulkarni   +9 more
openaire   +3 more sources

The Complement Receptors C3aR and C5aR Are a New Class of Immune Checkpoint Receptor in Cancer Immunotherapy

Frontiers in Immunology, 2019
Cancer immunotherapy has made remarkable clinical advances in recent years. Antibodies targeting the immune checkpoint receptors PD-1 and CTLA-4 and adoptive cell therapy (ACT) based on ex vivo expanded peripheral CTLs, tumor infiltrating lymphocytes ...
Yu Wang, Hui Zhang, You-Wen He
doaj   +1 more source

Calcareous nannofossil biostratigraphy of the M. del Casino section (northern Apennines, Italy) and paleoceanographic conditions at times of Late Miocene sapropel formation [PDF]

, 1998
A detailed quantitative calcareous nannofossil analysis has been performed on 138 samples from the astronomically dated Monte del Casino section with the aim to identify and precisely date the most important calcareous nannofossil events across the ...
Giunta, S., Hilgen, F.J., Krijgsman, W., Negri, A., Vai, G.B.   +4 more
core