Results 101 to 110 of about 3,979 (154)

C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy

JCI Insight
The deposition of antipodocyte autoantibodies in the glomerular subepithelial space induces primary membranous nephropathy (MN), the leading cause of nephrotic syndrome worldwide.
Qi Zhang, Sofia Bin, Kelly Budge, Astgik Petrosyan, Valentina Villani, Paola Aguiari, Coralien Vink, Jack Wetzels, Hasmik Soloyan, Gaetano La Manna, Manuel Alfredo Podestà, Paolo Molinari, Sargis Sedrakyan, Kevin V. Lemley, Roger E. De Filippo, Laura Perin, Paolo Cravedi, Stefano Da Sacco   +17 more
doaj   +1 more source

Complement Proteins C1q-C5 as Context‑Dependent Regulators of Osteoblast Function and Fracture Healing: A Systematic Review. [PDF]

Orthop Rev (Pavia)
Counts PR, Baer TM, Viswanath O, Ganti L.   +3 more
europepmc   +1 more source

C3aR inhibition alleviates cerebral ischemia-reperfusion injury via STING-mediated ferroptosis through SLC7A11/GPX4. [PDF]

iScience
Zhang Y, Xia Y, Chen Z, Hou S, Li J, Pang M, Wang Y.   +6 more
europepmc   +1 more source

Multi-Omics and Experimental Validation Reveal the Protective Effect of Paeoniflorin Against Coronary Heart Disease in Mice via Inhibiting the C3-Cfd-C3aR Pathway. [PDF]

Int J Mol Sci
Yang Y, Li X, Zong W, Wu S, Li Y, Tang D, Zhang H.   +6 more
europepmc   +1 more source

Maternal Stress Primes Adolescent Stress Susceptibility via Microglial Complement-Dependent Synaptic Phagocytosis. [PDF]

Research (Wash D C)
Wang X, Jiang M, Wei L, Liang X, Fang F, Xie Y, Cang J.   +6 more
europepmc   +1 more source

Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis. [PDF]

Mol Med Rep
Lu S, Luo F, Chen N, Shi G, Chen Y.
europepmc   +1 more source

Early amyloid pathology in mice synergistically worsens post-sepsis behavioral impairment and microglial synaptic phagocytosis. [PDF]

Brain Behav Immun Health
Giffin KA, Puranik N, Bustamante AC, Padilla M, Zeng Z, Randolph G, Wheaton L, Moore S, Newstead M, Denstaedt SJ, Spencer-Segal J, Singer BH.   +11 more
europepmc   +1 more source

Fibrinogen-like protein 2-complement C3 interaction exacerbates tubular inflammation in acute kidney injury by elevating complement C3a levels. [PDF]

Ren Fail
Wan W, Yang Q, Li J, Wu S, Hu X, Ruan Z, Wang R, Zhang Z, Geng X, Zhou Y, Lu Q, Ren H.   +11 more
europepmc   +1 more source

[<i>Chaihu Shugan San</i> inhibits C3/C3aR-mediated microglial M1 polarization to improve hippocampal synaptic plasticity in mice with menopausal syndrome with liver <i>qi</i> stagnation]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Zhong Y, Cai X, Li X, Wang S, Wu Y, Chen Z, Wang Y, Shen B, Gong L, Shen J, Min L, Liang W.   +11 more
europepmc   +1 more source

Targeting the C3 signaling axis of the complement system: immune microenvironment regulation and emerging therapeutic strategies for glioblastoma. [PDF]

Front Immunol
Huang J, Wang Q, Chen J.
europepmc   +1 more source