Results 61 to 70 of about 3,979 (154)

Spatiotemporal heterogeneity and dynamic evolution of microglial glucose metabolic reprogramming in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Alzheimer's disease (AD) is accompanied by persistent disturbances in brain energy metabolism, and microglial glucose metabolic reprogramming constitutes an important link among pathological protein deposition, neuroinflammation, and impaired clearance.
Yuan Chen, Fuyao Li, Junlei Zhang, Mingqing Wei, Jingnian Ni, Ting Li, Lulu Yao, Jinzhou Tian, Jing Shi   +8 more
wiley   +1 more source

Down-Regulation of C3aR/C5aR Inhibits Cell Proliferation and EMT in Hepatocellular Carcinoma

Technology in Cancer Research & Treatment, 2020
Complement 3a (C3a) and complement 5a (C5a), small cleavage fragments generated by complement activation, has been previously shown to be obviously up-regulated in highly metastatic hepatocellular carcinoma (HCC) cells. However, their functional roles in
Bendong Chen MD, Wenyan Zhou MM, Chaofeng Tang MM, Genwang Wang MB, Peng Yuan MM, Yawen Zhang MB, Sah Chandra Bhushan MB, Jinlong Ma MB, Junzhi Leng MM   +8 more
doaj   +1 more source

Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells. [PDF]

PLoS ONE, 2011
The complement component C3a induces degranulation in human mast cells via the activation of cell surface G protein coupled receptors (GPCR; C3aR).
Arpana Vibhuti, Kshitij Gupta, Hariharan Subramanian, Qiang Guo, Hydar Ali   +4 more
doaj   +1 more source

An Immunoregulatory Role for Complement Receptors in Murine Models of Breast Cancer

Antibodies, 2021
The complement system has demonstrated roles in regulating tumor growth, although these may differ between tumor types. The current study used two murine breast cancer models (EMT6 and 4T1) to investigate whether pharmacological targeting of receptors ...
Fazrena Nadia Md Akhir, Mohd Hezmee Mohd Noor, Keith Weng Kit Leong, Jamileh A. Nabizadeh, Helga D. Manthey, Stefan E. Sonderegger, Jenny Nga Ting Fung, Crystal E. McGirr, Ian A. Shiels, Paul C. Mills, Trent M. Woodruff, Barbara E. Rolfe   +11 more
doaj   +1 more source

Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
This review summarizes potential functions of platelet factor 4 (PF4) in neurodegenerative diseases (NDs) and discusses its promise as both a biomarker and a therapeutic target. Further elucidation of PF4 signaling pathways may provide new insights into disease mechanisms and uncover novel opportunities for targeted interventions in NDs.
Qi Tian, Yanji Tong, Fang Yu, Xiaoming Hu   +3 more
wiley   +1 more source

Negative regulation of pulmonary Th17 responses by C3a anaphylatoxin during allergic inflammation in mice. [PDF]

PLoS ONE, 2012
Activation of complement is one of the earliest immune responses to exogenous threats, resulting in various cleavage products including anaphylatoxin C3a.
Hoyong Lim, Young Uk Kim, Scott M Drouin, Stacey Mueller-Ortiz, Kyoungah Yun, Eva Morschl, Rick A Wetsel, Yeonseok Chung   +7 more
doaj   +1 more source

Immune‐Cell Dynamics in the Tumor Microenvironment: Implications for Cancer Therapy

MedComm, Volume 7, Issue 10, October 2026.
Immune‐cell dynamics in the tumor microenvironment converge on four major barriers to effective therapy: failed immune access, defective antigen visibility and priming, loss of effector maintenance, and suppressive tissue remodeling. These barriers emerge from local hypoxic, cytokine, metabolic, and stromal signals.
Pin Guo, Yizhao Xie, Rui Song, Mengdi Yang, Zhen Lin, Chao Guan, Zechen Wang, Jin Wen, Guang‐Liang Chen   +8 more
wiley   +1 more source

Intratumoral Microbiota in Fueling Cancer and Steering Treatment Response

MedComm, Volume 7, Issue 10, October 2026.
Emerging research underscores the tumor‐specific colonization of microbiota and the role of intratumoral microbiota in cancer development and treatment resistance across multiple malignancies. Here, we provide a systematic review exploring the latest biotechnological advancements for studying low‐abundance intratumoral microbiota, their origins ...
Minhui Xu, Jie Yu, Ying Chen, Shengfang Ge, Lin Ye, Yefei Wang, Yixiong Zhou, Renbing Jia   +7 more
wiley   +1 more source

Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review systematically examines the role of gut microbiota modulation in Alzheimer's disease, focusing on how microbial metabolites and dietary nutrients influence cognitive function and AD pathology, as well as the neuroprotective effects through the gut‐brain axis.
Binyue Xu, Xuhuan Li, Shangling Dong, Zheyuan Zhang, Dong Jin, Guoping Li, Jiesheng Wang   +6 more
wiley   +1 more source

Agonist-induced receptor internalization in RBL-2H3 cells expressing C3aR and mutants.

, 2013
Cells stably expressing either WT-C3aR (A) or its mutants (B–D) were exposed to buffer (−C3a) or C3a (+C3a, 100 nM) for 5 min at 37°C. Cells were washed and C3aR expression was analyzed by flow cytometry.
Andreas Klos (71279), Hydar Ali (292814), Kshitij Gupta (292813), Hariharan Subramanian (292812)   +3 more
core   +1 more source