Results 1 to 10 of about 264,280 (300)

Association of the porcine C3 gene with haemolytic complement activity in the pig [PDF]

Genetics Selection Evolution, 2003
The complement component C3 plays an essential role in the activated complement system, which is involved in phagocytosis, inflammation and immunoregulation to destroy infectious microorganisms.
Mekchay Supamit, Ponsuksili Siriluck, Schellander Karl, Wimmers Klaus   +3 more
doaj   +2 more sources

Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes [PDF]

Journal of Hematology & Oncology, 2017
Background C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular ...
Michela Sica, Tommaso Rondelli, Patrizia Ricci, Maria De Angioletti, Antonio M. Risitano, Rosario Notaro   +5 more
doaj   +3 more sources

Complement C3 recognition by C3 convertases. [PDF]

Sci Adv
Abstract The complement system plays a fundamental role in human immunity, and its dysregulation is implicated in numerous diseases. Activation of the complement occurs through three main pathways: classical, lectin, and alternative; which converge at the central component, C3.
Jia C, Yang X, Zhao MH, Tan Y, Xiao J.
europepmc   +2 more sources

The versatile functions of complement C3-derived ligands [PDF]

Immunological Reviews, 2016
The complement system is a major component of immune defense. Activation of the complement cascade by foreign substances and altered self-structures may lead to the elimination of the activating agent, and during the enzymatic cascade, several ...
Ahearn, Altieri, Andrews, Arvieux, Aubry, Baiu, Bajtay, Bajtay, Barro, Baudino, Bellinger-Kawahara, Berger, Beyer, Bohnsack, Bretscher, Cabec, Cardone, Carroll, Carroll, Carroll, Carter, Carter, Castro, Chen, Chen, Colten, Corbi, Cravedi, Daha, Dempsey, Diamond, Ehirchiou, Erdei, Erdei, Erdei, Erdei, Erdei, Ezekowitz, Fearon, Fingeroth, Flick, Frade, Gadjeva, Georgakopoulos, Ghannam, Ghebrehiwet, Gros, Gupta, Han, Heeger, Helmy, Holers, Hynes, Iida, Illges, Ingalls, Isaak, Jacobson, Jozsi, Karnchanaphanurach, Kemper, Kerekes, Kerekes, Kerekov, Klos, Kooten, Kremlitzka, Kuraya, Kurtz, Law, Law, Li, Li, Liddington, Lu, Luxembourg, Maison, Marquart, Marquart, Matsumoto, Melchers, Miller, Miller, Mitchell, Mold, Molina, Morelli, Mueller-Ortiz, Nelson, Nemerow, Nicolaou, Nielsen, Ogembo, Olesen, Oliva, Pantazis, Papp, Patel, Pepys, Peyron, Pliyev, Postigo, Praz, Prechl, Prechl, Prieto, Prodeus, Puentes, Ramos, Raposo, Reis, Renzo, Ross, Rubtsov, Sacks, Sandor, Sandor, Schlesinger, Schmidt, Sim, Sim, Singh-Jasuja, Sissons, Skoberne, Sohn, Strainic, Strijp, Tan, Tedder, Thacker, Torok, Torok, Touw, Tsokos, Tsokos, Tsokos, Tuveson, Ueda, Ugarova, Verbovetski, Villiers, Wagner, Watry, Wehr, Weiss, White, Wilson, Wright, Yan, Zaffran, Zhang, Zhou, Zhou   +152 more
core   +6 more sources

Serum complement C3 as a diagnostic biomarker for metabolic dysfunction -associated steatotic liver disease in middle-aged and elderly adults: a cross-sectional study [PDF]

BMC Gastroenterology
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease globally, with significant liver fibrosis (SLF) determining clinical outcomes.
Dan Ye, Haifen Ma, Jingjing Zhou, Jiaofeng Wang, Jiaheng Shi, Jie Chen, Zhijun Bao, Xiaona Hu   +7 more
doaj   +2 more sources

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Barthel, Diana, Böhm, Sascha, Elsen, Jean van den, Koch, Tina K., Kraiczy, Peter, Reuter, Michael, Skerka, Christine, Zipfel, Peter F.   +7 more
core   +12 more sources

Association between complement C3 and the prevalence of metabolic-associated fatty liver disease in a Chinese population: a cross-sectional study

BMJ Open, 2021
Objectives Recently studies demonstrated that adipose tissue can produce and release complement C3 and serum complement C3 levels were associated with diabetes mellitus, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD).
Wei-Lin Wang, Ying Zhao, Limin Feng
doaj   +1 more source

Development of a C3 humanized rat as a new model for evaluating novel C3 inhibitors

Journal of Innate Immunity, 2023
Introduction: C3 is central for all complement activation pathways, thus an attractive therapeutic target. Many C3-targeted agents are under extensive development with one already approved for clinical use.
Jin Chen, Lingjun Zhang, Maojing Yang, Elizabeth D. Hughes, Zachary T. Freeman, Thomas L. Saunders, Feng Lin   +6 more
doaj   +1 more source

SERUM C3 AND SERUM C4 COMPLEMENT IN PATIENTS WITH BURN TRAUMA AND CORRELATION WITH BURN INJURY SEVERITY

Sanamed, 2022
Introduction: Burns, depending on the degree of severity, induce a significant pathophysiological response in the body. The complement system participates in the body's defenses as well as in immune responses after burn-induced trauma. Objectives: The
Arslanagic Selma, Karamehic Jasenko
doaj   +1 more source

A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates [PDF]

PeerJ, 2019
Background Complement factor C3 represents the central component of the complement cascade and its activation split product C3a plays an important role in inflammation and disease. Many human disorders are linked to dysregulation of the complement system
Wolfgang Winnicki, Peter Pichler, Karl Mechtler, Richard Imre, Ines Steinmacher, Gürkan Sengölge, Daniela Knafl, Georg Beilhack, Ludwig Wagner   +8 more
doaj   +2 more sources