Results 21 to 30 of about 264,280 (300)

Complement C3 variant and the risk of age-related macular degeneration [PDF]

, 2007
Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors.
Armbrecht, AM, Bird, AC, Clayton, DG, Deary, IJ, Dhillon, B, Genetic Factors AMD Study G, Hayward, C, Khan, JC, Matharu, BK, Moore, AT, Morgan, J, Redmond, E, Sepp, T, Shahid, H, Thurlby, DA, Wright, AF, Yates, JRW   +16 more
core   +1 more source

HIV induces expression of complement component C3 in astrocytes by NF-κB-dependent activation of interleukin-6 synthesis [PDF]

, 2017
Background Abnormal activation of the complement system contributes to some central nervous system diseases but the role of complement in HIV-associated neurocognitive disorder (HAND) is unclear.
Borjabad, Alejandra, Chao, Wei, Emdad, Luni, Fisher, Paul B., Morgello, Susan, Murray, Jacinta, Nitkiewicz, Jadwiga, Potash, Mary Jane, Volsky, David J.   +8 more
core   +2 more sources

Circulating Complement Levels and C3 Glomerulopathy [PDF]

Clinical Journal of the American Society of Nephrology, 2014
The complement system is an essential part of innate immunity acting as a first-line defense against infection and provides an interface between innate and adaptive immunity ([1][1],[2][2]). It consists of a network of soluble (fluid phase) and cell membrane proteins (solid phase).
Fernando C, Fervenza, Sanjeev, Sethi
openaire   +2 more sources

Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H

Frontiers in Immunology, 2020
Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig, Anne K. Mühlig, Lindsay S. Keir, Jana C. Abt, Hannah S. Heidelbach, Rachel Horton, Gavin I. Welsh, Catherine Meyer-Schwesinger, Christoph Licht, Richard J. Coward, Lars Fester, Lars Fester, Moin A. Saleem, Jun Oh, Jun Oh   +14 more
doaj   +1 more source

Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]

, 2016
Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J., Baré, Patricia, De Giorgi, Valeria, Grandinetti, Teresa, Matsuura, Kentaro, Salam, Kazi Abdus, Schechterly, Cathy, Wang, Richard   +7 more
core   +1 more source

Serological and genetic complement alterations in infection-induced and complement-mediated hemolytic uremic syndrome [PDF]

, 2016
Background: The role of complement in the atypical form of hemolytic uremic syndrome (aHUS) has been investigated extensively in recent years. As the HUS-associated bacteria Shiga-toxin-producing Escherichia coli (STEC) can evade the complement system ...
Bakker, J.A. (Jaap), Bouts, A.H. (Antonia), Dorresteijn, E.M. (Eiske), Goertz, J. (Joop), Gracchi, V. (Valentina), Heuvel, L.P. (Lambert) van den, Jeronimus-Klaasen, A. (Annelies), Kar, N.C. (Nicole) van de, Keijzer-Veen, M.G. (Mandy), Roos, A. (Anja), van der Molen, R.G. (Renate G.), van der Velden, T.J.A.M. (Thea J. A. M.), van Wijk, J.A.E. (Joanna A. E.), Volokhina, E.B. (Elena), Westra, D.F.   +14 more
core   +9 more sources

Correlation between serum level of complement C3 and abdominal aortic calcification in maintenance hemodialysis patients

Linchuang shenzangbing zazhi, 2021
Objective To explore the correlation between serum level of complement C3 and abdominal aortic calcification（AAC）in maintenance hemodialysis（MHD）patients.Methods A total of 127 MHD patients hospitalized between February 2019 and December 2019 were ...
Zhao Xin, Bi Chun-sheng
doaj  

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

Cell Reports, 2019
Summary: Complement pathway overactivation can lead to neuronal damage in various neurological diseases. Although Alzheimer’s disease (AD) is characterized by β-amyloid plaques and tau tangles, previous work examining complement has largely focused on ...
Tiffany Wu, Borislav Dejanovic, Vineela D. Gandham, Alvin Gogineni, Rose Edmonds, Stephen Schauer, Karpagam Srinivasan, Melanie A. Huntley, Yuanyuan Wang, Tzu-Ming Wang, Maj Hedehus, Kai H. Barck, Maya Stark, Hai Ngu, Oded Foreman, William J. Meilandt, Justin Elstrott, Michael C. Chang, David V. Hansen, Richard A.D. Carano, Morgan Sheng, Jesse E. Hanson   +21 more
doaj   +1 more source

Linking Complement C3 and B Cells in Nasal Polyposis

Journal of Immunology Research, 2020
Nasal polyposis often is characterized by a persistent inflammation of the sinonasal mucosa, disease recurrence after medical or surgical intervention, and asthma comorbidity.
Ulrike Werner, Axel Künstner, Maren Drenckhan, Ralph Pries, Karl-Ludwig Bruchhage, Hauke S. Busch, Claus Bachert, Barbara Wollenberg   +7 more
doaj   +1 more source

Systemic complement activation levels in Stargardt disease.

PLoS ONE, 2021
PurposePreclinical research provides evidence for the complement system as a potential common pathway in Stargardt disease (STGD1) and age-related macular degeneration (AMD) leading to retinal pigment epithelium (RPE) loss.
Patty P A Dhooge, Esmee H Runhart, Catherina H Z Li, Corrie M de Kat Angelino, Carel B Hoyng, Renate G van der Molen, Anneke I den Hollander   +6 more
doaj   +1 more source