The Role of Complement in Cancer Immunotherapy [PDF]
, 2022 The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the ...
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Complement C3 deficiency alleviates alkylation-induced retinal degeneration in mice
Eye and Vision, 2022 Background It has been found that the extensive use of anticancer drugs containing DNA-alkylating agents not only target cancer cells but also cause retinal inflammation through toxic intermediates.
Lu Du, Guang-Hua Peng
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Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]
, 2013 Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Christine Skerka +24 more
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Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1 [PDF]
, 2010 It has been reported that complement is activated on the surface of activated platelets, despite the presence of multiple regulators of complement activation. To reinvestigate the mechanisms by which activated platelets bind to complement components, the
Nilsson Ekdahl, Kristina, +12 more
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Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H
Frontiers in Immunology, 2020 Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig +14 more
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Complement component C3 transcription in Atlantic halibut (Hippoglossus hippoglossus L.) larvae [PDF]
, 2006 The complement systems of fish are well developed and play an important role in the innate immune response. Complement C3 is the central protein of all three activation pathways and is the major opsonin of the complement system and essential for the ...
Lange, S. +6 more
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Circulating Complement Levels and C3 Glomerulopathy [PDF]
Clinical Journal of the American Society of Nephrology, 2014 The complement system is an essential part of innate immunity acting as a first-line defense against infection and provides an interface between innate and adaptive immunity ([1][1],[2][2]). It consists of a network of soluble (fluid phase) and cell membrane proteins (solid phase).
Fernando C, Fervenza, Sanjeev, Sethi
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Complement activation does not play a direct role in model chemotherapeutic - induced mucositis [PDF]
, 2023 Chemotherapeutic agents are highly efficient in the treatment of various cancers; however, many of the drugs also lead to unwanted toxicities. “Mucositis” describes the injury caused by these cytotoxic agents to the healthy mucosa of the digestive tract.
Aljamei, Hanan
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Linchuang shenzangbing zazhi, 2021 Objective To explore the correlation between serum level of complement C3 and abdominal aortic calcification（AAC）in maintenance hemodialysis（MHD）patients.Methods A total of 127 MHD patients hospitalized between February 2019 and December 2019 were ...
Zhao Xin, Bi Chun-sheng
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Cell Reports, 2019 Summary: Complement pathway overactivation can lead to neuronal damage in various neurological diseases. Although Alzheimer’s disease (AD) is characterized by β-amyloid plaques and tau tangles, previous work examining complement has largely focused on ...
Tiffany Wu +21 more
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