Frontiers in Genetics, 2021 Schizophrenia is a common neuropsychiatric disorder with complex pathophysiology. Recent reports suggested that complement system alterations contributed to pathological synapse elimination that was associated with psychiatric symptoms in schizophrenia ...
Yu Chen +11 more
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Arthritis Research & Therapy, 2021 Background Screening abnormal pathways and complement components in the kidneys of patients with lupus nephritis (LN) and NZB/W mice may help to identify complement-related therapeutic targets for LN.
Tao Liu +6 more
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Diverse Clinical Presentations of C3 Dominant Glomerulonephritis
Frontiers in Medicine, 2020 C3 dominant immunofluorescence staining is present in a subset of patients with idiopathic immune complex membranoproliferative glomerulonephritis (iMPGN).
Ramy M. Hanna +13 more
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Therapeutic Advances in Chronic Disease, 2020 Objective: To analyze the relationship between complement component 3 (C3) and the prevalence of cardiometabolic risk factors and disease activity in the rheumatic diseases having the highest rates of cardiovascular morbidity and mortality: rheumatoid ...
Iván Arias de la Rosa +17 more
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Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]
, 2012 Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel +17 more
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Analysis of C3 suggests three periods of positive selection events and different evolutionary patterns between fish and mammals. [PDF]
PLoS ONE, 2012 BACKGROUND: The third complement component (C3) is a central protein of the complement system conserved from fish to mammals. It also showed distinct characteristics in different animal groups.
Fanxing Meng +5 more
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Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance [PDF]
, 2010 Complement activation is known to have deleterious effects on organ transplantation. On the other hand, the complement system is also known to have an important role in regulating immune responses.
Cook, T +21 more
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Complement C3 deficiency alleviates alkylation-induced retinal degeneration in mice
Eye and Vision, 2022 Background It has been found that the extensive use of anticancer drugs containing DNA-alkylating agents not only target cancer cells but also cause retinal inflammation through toxic intermediates.
Lu Du, Guang-Hua Peng
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Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]
, 2013 Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Christine Skerka +24 more
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Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H
Frontiers in Immunology, 2020 Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig +14 more
doaj +1 more source