Results 41 to 50 of about 264,280 (300)

Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig- to-rat xenotransplantation [PDF]

, 1995
In normal rats, the xenobiotic K76 inhibited the C5 and probably the C2 and C3 steps of complement and effectively depressed classical complement pathway activity, alternative complement pathway activity, and the C3 complement component during and well ...
Adachi, Anthony J. Demetris, Cochrane, Gewurz, Hasan, Hideaki Miyazawa, Hong, Iida, Kissmeyer-Nielsen, Kitano, Kitano, Leventhal, Minoru Nomoto, Mitsuko Tanaka, Miyagawa, Miyagawa, Miyazaki, Miyazaki, Miyazawa, Murase, Nelson, Noriko Murase, Ono, Perper, Pruitt, Pruitt, Qing Ye, Rafael Manez, Satoru Todo, Soares, Starzl, Starzl, Starzl, Starzl, Tanaka, Thomas E. Starzl, Valdivia, Van den Bogaerde, Wasei Miyazaki, Xia, Yamamoto, Yoichi Toyama   +41 more
core   +2 more sources

Complement C3 and Nonalcoholic Fatty Liver Disease in Chronic Kidney Disease Patients: A Pilot Study

Kidney & Blood Pressure Research, 2020
Context: Evidences have suggested complement C3 is a biomarker for nonalcoholic fatty liver disease (NAFLD) in the general population. Objective: The present study was conducted to explore the predictive function of C3 for NAFLD in chronic kidney disease
Binbin Pan, Xin Wan, Mengqing Ma, Changchun Cao   +3 more
doaj   +1 more source

TGF-β Signaling Regulates Neuronal C1q Expression and Developmental Synaptic Refinement [PDF]

, 2014
Immune molecules, including complement proteins C1q and C3, have emerged as critical mediators of synaptic refinement and plasticity. Complement localizes to synapses and refines the developing visual system via C3-dependent microglial phagocytosis of ...
Bialas, Allison R., Stevens, Beth
core   +1 more source

Bacterial infections in a pediatric cohort of primary and acquired complement deficiencies

Pediatric Rheumatology Online Journal, 2020
Background Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels.
Taha Al-Shaikhly, Kristen Hayward, Matthew L. Basiaga, Eric J. Allenspach   +3 more
doaj   +1 more source

A Novel Homozygous In-Frame Deletion in Complement Factor 3 Underlies Early-Onset Autosomal Recessive Atypical Hemolytic Uremic Syndrome - Case Report

Frontiers in Immunology, 2021
Background and ObjectivesAtypical hemolytic uremic syndrome (aHUS) is mostly attributed to dysregulation of the alternative complement pathway (ACP) secondary to disease-causing variants in complement components or regulatory proteins.
Shirley Pollack, Shirley Pollack, Israel Eisenstein, Adi Mory, Tamar Paperna, Ayala Ofir, Hagit Baris-Feldman, Karin Weiss, Nóra Veszeli, Dorottya Csuka, Revital Shemer, Fabian Glaser, Zoltán Prohászka, Daniella Magen, Daniella Magen   +14 more
doaj   +1 more source

C3 glomerulonephritis with genetically confirmed C3 deficiency in a pediatric patient: a case report [PDF]

Childhood Kidney Diseases
Complement component 3 glomerulonephritis (C3GN) is a rare kidney disease characterized by complement dysregulation that results in prominent complement component 3 (C3) deposition in the kidneys. The clinical course of C3GN varies from mild hematuria to
Hae Min Kim, Jae Il Shin, Ji Hong Kim, Jiyoung Oh, Ji-Man Kang, Hee Gyung Kang, Seong Heon Kim, Byoung Soo Cho, Keum Hwa Lee   +8 more
doaj   +1 more source

Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

Frontiers in Immunology, 2020
Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism, which were linked to physical function.
Chi Zhang, Chi Zhang, Shihui Fu, Minghao Zhao, Deping Liu, Deping Liu, Yali Zhao, Yao Yao, Yao Yao   +8 more
doaj   +1 more source

Platelet-bound complement (C3) in immune thrombocytopenia [PDF]

Blood, 1977
The fixation of complement to the circulating platelet in immune thrombocytopenia was detected by measurement of one of the complement components, C3, on the surface of platelets from patients with idiopathic thrombocytopenic purpura (ITP) and systemic lupus erythematosus (SLE) using the anti-C3 consumption assay.
T W, Hauch, W F, Rosse
openaire   +3 more sources

C3 Glomerulopathy: A Rare Entity with Future Directions

Revista Portuguesa de Nefrologia e Hipertensão, 2023
C3 glomerulopathies are a rare group of glomerular diseases resulting from excessive activation of the alternative complement pathway. The pathogenesis involves genetic, acquired, or immunologic defects in regulators of the alternative complement ...
Sara Vilela, Catarina Cardoso, Sara Barreto, Gonçalo Cruz, Pedro Bravo, Cristina Santos   +5 more
doaj   +1 more source

Complement Component C3 and Complement Factor B Promote Growth of Cutaneous Squamous Cell Carcinoma [PDF]

, 2017
Cutaneous squamous cell carcinoma (cSCC) is one of the most common metastatic skin cancers with increasing incidence. We examined the roles of complement component C3 and complement factor B (CFB) in the growth of cSCC. Analysis of cSCC cell lines (n = 8)
Farshchian, Mehdi, Grenman, Reidar, Heljasvaara, Ritva, Kahari, Veli-Matti, Kallajoki, Markku, Kivisaari, Atte, Meri, Seppo, Nissinen, Liisa, Peltonen, Juha, Peltonen, Sirkku, Pihlajaniemi, Taina, Riihila, Pilvi   +11 more
core   +1 more source