Results 41 to 50 of about 92,727 (298)

Structural basis for complement factor H-linked age-related macular degeneration [PDF]

, 2007
Nearly 50 million people worldwide suffer from age-related macular degeneration (AMD), which causes severe loss of central vision. A single-nucleotide polymorphism in the gene for the complement regulator factor H (FH), which causes a Tyr-to-His ...
Pietro Roversi, Clark, S, Robert B. Sim, Susan M. Lea, Jowitt, Thomas A., Beverly E. Prosser, Prosser, Beverly E., Prosser, B, Day, Anthony J., Herbert, AP, Dušan Uhrín, Sim, Robert B., Uhrin, Dusan, Barlow, P, Johnson, S, Lea, SM, Steven Johnson, Blaum, Barbel S., Barlow, Paul N., Herbert, A, Barlow, PN, Sim, RB, Simon J. Clark, Roversi, P, Uhrín, D, Johnson, Steven, Thomas A. Jowitt, Day, A, Jowitt, Thomas A.; id_orcid, Edward Tarelli, Jess Tyrrell, Lea, Susan M., Tyrrell, J, Blaum, BS, Herbert, Andrew P., Clark, Simon J., Tyrrell, Jess, Day, Anthony J.; id_orcid, Lea, Susan, Tarelli, E, Clark, SJ, Paul N. Barlow, Bärbel S. Blaum, Clark, Simon; id_orcid, Tarelli, Edward, Prosser, BE, Jowitt, TA, Day, AJ, Andrew P. Herbert, Roversi, Pietro, Anthony J. Day   +50 more
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Venous Air Embolism Activates Complement C3 Without Corresponding C5 Activation and Trigger Thromboinflammation in Pigs [PDF]

, 2022
Introduction: Air embolism may complicate invasive medical procedures. Bubbles trigger complement C3-mediated cytokine release, coagulation, and platelet activation in vitro in human whole blood.
Nilsen, Bent Aksel, Ludviksen, Judith K, Christiansen, Dorte, Landsem, Anne, Mollnes, Tom Eirik, Fure, Hilde, Dybwik, Knut Gustav, Storm, Benjamin, Braaten, Tonje, Nielsen, Erik Waage, Pettersen, Kristin   +10 more
core   +1 more source

Association of the porcine C3 gene with haemolytic complement activity in the pig

Genetics Selection Evolution, 2003
The complement component C3 plays an essential role in the activated complement system, which is involved in phagocytosis, inflammation and immunoregulation to destroy infectious microorganisms.
Mekchay Supamit, Ponsuksili Siriluck, Schellander Karl, Wimmers Klaus   +3 more
doaj   +1 more source

Complement content in plasma under different storage conditions

Zhongguo shuxue zazhi, 2023
Objective To investigate the changes in complement content in component blood before blood transfusion. Methods 180 samples from 20 plasma donors were collected at different stages of the preparation process, stored at different temperatures and time ...
Zhi HAN, Yujie HAN, Haihong ZHANG
doaj   +1 more source

Comparative characteristics of the complement system in patients with C3-glomerulopathy and atypical hemolytic uremic syndrome of chronic course who suffered an acute episode of thrombotic microangiopathy

Терапевтический архив, 2023
Aim. To compare changes in the complement system in C3-glomerulopathy (C3-GP) and atypical hemolytic uremic syndrome (aHUS) after the relief of an acute episode of thrombotic microangiopathy. Materials and methods.
Valeriya A. Yurova, Natalia L. Kozlovskaya, Larisa A. Bobrova, Leonid V. Kozlov, Svetlana S. Andina, Kseniya A. Demyanova   +5 more
doaj   +1 more source

Defining the Complement Biomarker Profile of C3 Glomerulopathy [PDF]

Clinical Journal of the American Society of Nephrology, 2014
C3 glomerulopathy (C3G) applies to a group of renal diseases defined by a specific renal biopsy finding: a dominant pattern of C3 fragment deposition on immunofluorescence. The primary pathogenic mechanism involves abnormal control of the alternative complement pathway, although a full description of the disease spectrum remains to be determined.
Zhang, Yuzhou, Nester, Carla M, Martin, Bertha, Skjoedt, Mikkel-Ole, Meyer, Nicole C, Shao, Dingwu, Borsa, Nicolò, Palarasah, Yaseelan, Smith, Richard J H   +8 more
openaire   +3 more sources

Structure of Complement C3(H2O) Revealed By Quantitative Cross-Linking/Mass Spectrometry And Modeling [PDF]

, 2016
<p>The slow but spontaneous and ubiquitous formation of C3(H2O), the hydrolytic and conformationally rearranged product of C3, initiates antibody-independent activation of the complement system that is a key first line of antimicrobial defense. The
Fischer, L, Nilges, M, Sali, A, Chen, ZA (8220201), Pellarin, R (8220204), Sali, A (5802812), Barlow, PN (8220213), Rappsilber, J (8220216), Chen, ZA, Nilges, M (8220210), Barlow, PN, Pellarin, R, Rappsilber, J, Fischer, L (8220207)   +13 more
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Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting

Scientific Reports, 2017
Complement protein C3 is the pivotal component of the complement system. Previous studies have demonstrated that C3 has implications in various human diseases and exerts profound functions under certain conditions.
Wei Zhang, Guan Wang, Ying Wang, Yong Jin, Lihua Zhao, Qiang Xiong, Lining Zhang, Lisha Mou, Rongfeng Li, Haiyuan Yang, Yifan Dai   +10 more
doaj   +1 more source

The versatile functions of complement C3‐derived ligands [PDF]

Immunological Reviews, 2016
SummaryThe complement system is a major component of immune defense. Activation of the complement cascade by foreign substances and altered self‐structures may lead to the elimination of the activating agent, and during the enzymatic cascade, several biologically active fragments are generated.
Erdei, Anna, Sándor, Noémi, Mácsik-Valent, Bernadett, Lukácsi, Szilvia Zsófia, Kremlitzka, Mariann, Bajtay, Zsuzsanna   +5 more
openaire   +4 more sources

A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB. [PDF]

, 2010
Viruses have evolved to evade the host's complement system. The open reading frames 4 (ORF4) of gammaherpesviruses encode homologs of regulators of complement activation (RCA) proteins, which inhibit complement activation at the level of C3 and C4 ...
Stewart, James P., Stipan, J., Adler, Heiko, James P Stewart, Adler Barbara, Adler, Barbara, Heiko Adler, Beatrix Steer, Barbara Adler, Jonjic Stipan, Stipan Jonjic, Steer, Beatrix, Steer Beatrix, Steer, B., Adler Heiko, Stewart James P., Adler, H., Adler, B., Jonjic, Stipan, James P. Stewart, Stewart, J.P.   +20 more
core   +1 more source