The versatile functions of complement C3‐derived ligands [PDF]
Immunological Reviews, 2016 SummaryThe complement system is a major component of immune defense. Activation of the complement cascade by foreign substances and altered self‐structures may lead to the elimination of the activating agent, and during the enzymatic cascade, several biologically active fragments are generated.
Erdei, Anna +5 more
openaire +4 more sources
The Role of Complement in Cancer Immunotherapy [PDF]
, 2022 The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the ...
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Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes
Journal of Hematology & Oncology, 2017 Background C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular ...
Michela Sica +5 more
doaj +1 more source
Complement C3 and Nonalcoholic Fatty Liver Disease in Chronic Kidney Disease Patients: A Pilot Study
Kidney & Blood Pressure Research, 2020 Context: Evidences have suggested complement C3 is a biomarker for nonalcoholic fatty liver disease (NAFLD) in the general population. Objective: The present study was conducted to explore the predictive function of C3 for NAFLD in chronic kidney disease
Binbin Pan +3 more
doaj +1 more source
Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]
, 2012 Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Teresia Hallström +14 more
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C3 glomerulonephritis with genetically confirmed C3 deficiency in a pediatric patient: a case report [PDF]
Childhood Kidney DiseasesComplement component 3 glomerulonephritis (C3GN) is a rare kidney disease characterized by complement dysregulation that results in prominent complement component 3 (C3) deposition in the kidneys. The clinical course of C3GN varies from mild hematuria to
Hae Min Kim +8 more
doaj +1 more source
Bacterial infections in a pediatric cohort of primary and acquired complement deficiencies
Pediatric Rheumatology Online Journal, 2020 Background Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels.
Taha Al-Shaikhly +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Background and ObjectivesAtypical hemolytic uremic syndrome (aHUS) is mostly attributed to dysregulation of the alternative complement pathway (ACP) secondary to disease-causing variants in complement components or regulatory proteins.
Shirley Pollack +14 more
doaj +1 more source
Complement activation does not play a direct role in model chemotherapeutic - induced mucositis
, 2023 Chemotherapeutic agents are highly efficient in the treatment of various cancers; however, many of the drugs also lead to unwanted toxicities. “Mucositis” describes the injury caused by these cytotoxic agents to the healthy mucosa of the digestive tract.
Aljamei, Hanan
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source