Results 51 to 60 of about 92,727 (298)

Complement C3 and Nonalcoholic Fatty Liver Disease in Chronic Kidney Disease Patients: A Pilot Study

Kidney & Blood Pressure Research, 2020
Context: Evidences have suggested complement C3 is a biomarker for nonalcoholic fatty liver disease (NAFLD) in the general population. Objective: The present study was conducted to explore the predictive function of C3 for NAFLD in chronic kidney disease
Binbin Pan, Xin Wan, Mengqing Ma, Changchun Cao   +3 more
doaj   +1 more source

The ontogeny of complement component C3 in Atlantic cod (Gadus morhua L.)—an immunohistochemical study [PDF]

, 2004
The complement system in fish is well developed and plays an important role in the immune response. Very little is known about the ontogeny of C3 in fish and no study has previously been done on the development of C3 in teleosts.
Lange, S., Bambir, S., Dodds, A.W., Magnadóttir, B.   +3 more
core   +1 more source

Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes

Journal of Hematology & Oncology, 2017
Background C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular ...
Michela Sica, Tommaso Rondelli, Patrizia Ricci, Maria De Angioletti, Antonio M. Risitano, Rosario Notaro   +5 more
doaj   +1 more source

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]

, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Teresia Hallström, Peter F. Zipfel, Zipfel, Peter F, Christine Skerka, Hallström, Teresia, Kraiczy, Peter, Skerka, Christine, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Zipfel, Peter F., Reinhard Wallich, Peter Kraiczy, Stevenson, Brian, Brian Stevenson   +14 more
core   +1 more source

C3 glomerulonephritis with genetically confirmed C3 deficiency in a pediatric patient: a case report [PDF]

Childhood Kidney Diseases
Complement component 3 glomerulonephritis (C3GN) is a rare kidney disease characterized by complement dysregulation that results in prominent complement component 3 (C3) deposition in the kidneys. The clinical course of C3GN varies from mild hematuria to
Hae Min Kim, Jae Il Shin, Ji Hong Kim, Jiyoung Oh, Ji-Man Kang, Hee Gyung Kang, Seong Heon Kim, Byoung Soo Cho, Keum Hwa Lee   +8 more
doaj   +1 more source

Bacterial infections in a pediatric cohort of primary and acquired complement deficiencies

Pediatric Rheumatology Online Journal, 2020
Background Acquired complement deficiency can occur in the setting of autoimmune syndromes, such as systemic lupus erythematosus (SLE), with very low or, occasionally, undetectable C3 levels.
Taha Al-Shaikhly, Kristen Hayward, Matthew L. Basiaga, Eric J. Allenspach   +3 more
doaj   +1 more source

A Novel Homozygous In-Frame Deletion in Complement Factor 3 Underlies Early-Onset Autosomal Recessive Atypical Hemolytic Uremic Syndrome - Case Report

Frontiers in Immunology, 2021
Background and ObjectivesAtypical hemolytic uremic syndrome (aHUS) is mostly attributed to dysregulation of the alternative complement pathway (ACP) secondary to disease-causing variants in complement components or regulatory proteins.
Shirley Pollack, Shirley Pollack, Israel Eisenstein, Adi Mory, Tamar Paperna, Ayala Ofir, Hagit Baris-Feldman, Karin Weiss, Nóra Veszeli, Dorottya Csuka, Revital Shemer, Fabian Glaser, Zoltán Prohászka, Daniella Magen, Daniella Magen   +14 more
doaj   +1 more source

Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

Frontiers in Immunology, 2020
Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism, which were linked to physical function.
Chi Zhang, Chi Zhang, Shihui Fu, Minghao Zhao, Deping Liu, Deping Liu, Yali Zhao, Yao Yao, Yao Yao   +8 more
doaj   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

C3 Glomerulopathy: A Rare Entity with Future Directions

Revista Portuguesa de Nefrologia e Hipertensão, 2023
C3 glomerulopathies are a rare group of glomerular diseases resulting from excessive activation of the alternative complement pathway. The pathogenesis involves genetic, acquired, or immunologic defects in regulators of the alternative complement ...
Sara Vilela, Catarina Cardoso, Sara Barreto, Gonçalo Cruz, Pedro Bravo, Cristina Santos   +5 more
doaj   +1 more source