Results 31 to 40 of about 92,727 (298)

Association of Polymorphisms in Complement Component C3 Gene with Susceptibility to Systemic Lupus Erythematosus [PDF]

, 2011
Objective. Identification of the genes responsible for systemic lupus erythematosus (SLE). Methods. All the exons and putative promoter regions of 53 candidate genes (TNFRSF6 /Fas, TNFSF6/FasL, Fli1, TNFSF10/TRAIL, TNFSF12/TWEAK, Bcl-2 , PTEN, FADD ...
李志鴻;江伯倫, Miyagawa, H.; Yamai, M.; Sakaguchi, D.; Kiyohara, C.; Tsukamoto, H.; Kimoto, Y.; Nakamura, T.; Lee, J.-H.; Tsai, C.-Y.; Chiang, B.-L.; Shimoda, T.; Harada, M.; Tahira, T.; Hayashi, K.; Horiuchi, T.   +1 more
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Recurrent pyogenic infections caused by a novel Gln1420* mutation in the C3 gene

Frontiers in Pediatrics, 2022
C3 is a crucial protein of the complement system. Congenital C3 deficiency is extremely rare and manifests through recurrent, severe infections and should always be considered as a differential diagnosis of recurrent pyogenic infections. We report a case
Pedro Simão Coelho, Catarina Gouveia, Catarina Gouveia, Marta Valente Pinto, Conceição Neves, Ana Isabel Cordeiro, João Farela Neves, João Farela Neves, João Farela Neves   +8 more
doaj   +1 more source

COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA [PDF]

, 1993
Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ, Peters, DK, P J Lachmann, D K Peters, P W Mathieson, Oliveira, DBG, R Würzner, D B Oliveria, Mathieson, PW, Würzner, R, Oliveria, DB   +10 more
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Assessment of the Role of C3(H2O) in the Alternative Pathway

Frontiers in Immunology, 2020
In this study we investigate the hydrolysis of C3 to C3(H2O) and its ability to initiate activation via the alternative pathway (AP) of the complement system.
Karin Fromell, Anna Adler, Amanda Åman, Vivek Anand Manivel, Shan Huang, Claudia Dührkop, Kerstin Sandholm, Kristina N. Ekdahl, Kristina N. Ekdahl, Bo Nilsson   +9 more
doaj   +1 more source

Systemic complement activation levels in Stargardt disease.

PLoS ONE, 2021
PurposePreclinical research provides evidence for the complement system as a potential common pathway in Stargardt disease (STGD1) and age-related macular degeneration (AMD) leading to retinal pigment epithelium (RPE) loss.
Patty P A Dhooge, Esmee H Runhart, Catherina H Z Li, Corrie M de Kat Angelino, Carel B Hoyng, Renate G van der Molen, Anneke I den Hollander   +6 more
doaj   +1 more source

A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo [PDF]

, 2000
The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease susceptibility and severity according to the position of the
H. Terence Cook, Savill, John, Henson, Peter M, Cook, HT, Valerie A. Fadok, Taylor, P.R, Henson, PM, Mark J. Walport, Savill, JS, Walport, MJ, Philip R. Taylor, John S. Savill, Michael C. Carroll, Botto, M, Andrews, Mark, Taylor, PR, Fadok, Valerie A, Anna Carugati, Carroll, Michael C, Walport, Mark J, Carroll, MC, Marina Botto, Carugati, A, Peter M. Henson, Andrews, M, Mark Andrews, Botto, Marina, Fadok, VA, Carugati, Anna, Cook, H. Terence   +29 more
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CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. [PDF]

, 2009
Age-related macular degeneration (AMD) is a prevalent cause of blindness in Western societies. Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly been
Weber, Bernhard H. F., Fleckenstein, Monika, Frank G Holz, Weber, B. H., Hendrik P N Scholl, Scholl, Hendrik P. N., Tim Becker, Ulrich Mansmann, Weinberger Andreas W. A., Schmitz-Valckenberg Steffen, Mackensen, F., Herold Christine, Holz, Frank G, Scholl Hendrik P. N., Weber, Bernhard H F, Andreas Mössner, Keilhauer, Claudia N, Scholl, Hendrik P N, Fritsche, Lars G., Steffen Schmitz-Valckenberg, Schmitz-Valckenberg, S., Claudia N Keilhauer, Weinberger, A. W., Fritsche, Lars G, Weinberger, Andreas W. A., Pauleikhoff, D., Becker, T., Andreas W A Weinberger, Adrion, Christine, Mansmann Ulrich, Weber Bernhard H. F., Becker Tim, Göbel, Arno, Mackensen Friederike, Holz, F. G., Monika Fleckenstein, Göbel, A., Adrion Christine, Holz Frank G., Scholl, H. P., Friederike Mackensen, Mackensen, Friederike, Mansmann, Ulrich, Göbel Arno, Becker, Tim, Fleckenstein Monika, Mössner, Andreas, Lars G Fritsche, Fritsche Lars G., Keilhauer Claudia N., Schmitz-Valckenberg, Steffen, Fritsche, L. G., Herold, Christine, Arno Göbel, Daniel Pauleikhoff, Weinberger, Andreas, Christine Herold, Mansmann, U., Christine Adrion, Bernhard H F Weber, Mössner, A., Pauleikhoff, Daniel, Keilhauer, C. N., Herold, C., Holz, Frank G., Adrion, C., Mößner Andreas, Pauleikhoff Daniel, Fleckenstein, M.   +68 more
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Role of complement C3 in diabetic nephropathy

Linchuang shenzangbing zazhi, 2022
As one of the most common microvascular complications of diabetes， diabetic kidney disease （DKD） is one of the major causes of end-stage renal disease. Complement system participates in both innate and adaptive immunities of human body. Three pathways of
Wang Qing-qing, Wang Yue, Li Yan-bo, Sun Wei-xia   +3 more
doaj  

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Kouser, L, Cordula M. Stover, Munirah Abdul-Aziz, Robert B. Sim, Nayak, A, Lubna Kouser, L. Kouser (7639589), Kishore, U, M. Abdul-Aziz (7677725), R. B. Sim (7584038), U. Kishore (7639601), Cordula M. Stover (7117046), Abdul-Aziz, M, Annapurna Nayak, A. Nayak (7334981), Stover, CM, Sim, RB, Uday Kishore   +17 more
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Complement and Chlamydia psittaci: Early Complement-Dependent Events Are Important for DC Migration and Protection During Mouse Lung Infection

Frontiers in Immunology, 2021
The zoonotic intracellular bacterium Chlamydia psittaci causes life-threatening pneumonia in humans. During mouse lung infection, complement factor C3 and the anaphylatoxin C3a augment protection against C. psittaci by a so far unknown mechanism.
Martin Kohn, Christian Lanfermann, Robert Laudeley, Silke Glage, Claudia Rheinheimer, Andreas Klos   +5 more
doaj   +1 more source