Results 11 to 20 of about 92,727 (298)
Alternative C3 Complement System: Lipids and Atherosclerosis [PDF]
International Journal of Molecular Sciences, 2021 Familial hypercholesterolemia (FH) is increasingly associated with inflammation, a phenotype that persists despite treatment with lipid lowering therapies. The alternative C3 complement system (C3), as a key inflammatory mediator, seems to be involved in the atherosclerotic process; however, the relationship between C3 and lipids during plaque ...
Maisa Garcia-Arguinzonis +7 more
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Conformational Complexity of Complement Component C3 [PDF]
, 2007 The structures of native C3 and its major fragment C3c have provided a wealth of structural insights into the central protein of the complement system. The proteolytic activation steps, generating the important fragments C3b and iC3b, are thought to induce significant conformational changes in the molecule, yielding protein molecules with distinct ...
Janssen, B.J.C., Gros, P.
core +8 more sources
Linking Complement C3 and B Cells in Nasal Polyposis [PDF]
Journal of Immunology Research, 2020 Nasal polyposis often is characterized by a persistent inflammation of the sinonasal mucosa, disease recurrence after medical or surgical intervention, and asthma comorbidity.
Ulrike Werner +7 more
doaj +2 more sources
Kallikrein Cleaves C3 and Activates Complement [PDF]
Journal of Innate Immunity, 2017 The human plasma contact system is an immune surveillance system activated by the negatively charged surfaces of bacteria and fungi and includes the kallikrein-kinin, the coagulation, and the fibrinolytic systems. Previous work shows that the contact system also activates complement, and that plasma enzymes like kallikrein, plasmin, thrombin, and FXII ...
Sarah, Irmscher +12 more
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, 2012 Complement C3 is the central component of the human complement system. It is ~186 kDa in size, consisting of an α-chain (~110 kDa) and a β-chain (~75 kDa) that are connected by cysteine bridges. C3 in its native form is inactive. Cleavage of C3 into C3b (~177 kDa) and C3a (~9 kDa) is a crucial step in the complement activation cascade, which can be ...
Dinasarapu, Ashok Reddy +3 more
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The complement C3 protein family in invertebrates [PDF]
Invertebrate Survival Journal, 2011 Complement C3 plays a pivotal role in the innate immune system of mammals as the central component of the complement system essential for its activation mechanism and effecter function.
M Nonaka
doaj +3 more sources
Therapeutic Advances in Chronic Disease, 2020 Objective: To analyze the relationship between complement component 3 (C3) and the prevalence of cardiometabolic risk factors and disease activity in the rheumatic diseases having the highest rates of cardiovascular morbidity and mortality: rheumatoid ...
Iván Arias de la Rosa +17 more
doaj +1 more source
Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]
, 2012 Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel +17 more
core +1 more source
Analysis of C3 suggests three periods of positive selection events and different evolutionary patterns between fish and mammals. [PDF]
PLoS ONE, 2012 BACKGROUND: The third complement component (C3) is a central protein of the complement system conserved from fish to mammals. It also showed distinct characteristics in different animal groups.
Fanxing Meng +5 more
doaj +1 more source
Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance [PDF]
, 2010 Complement activation is known to have deleterious effects on organ transplantation. On the other hand, the complement system is also known to have an important role in regulating immune responses.
Cook, T +21 more
core +1 more source