Results 11 to 20 of about 664,741 (301)
Complement C3 recognition by C3 convertases. [PDF]
Sci AdvAbstract The complement system plays a fundamental role in human immunity, and its dysregulation is implicated in numerous diseases. Activation of the complement occurs through three main pathways: classical, lectin, and alternative; which converge at the central component, C3.
Jia C, Yang X, Zhao MH, Tan Y, Xiao J.
europepmc +3 more sources
Immunological Reviews, 2022 SummaryC3 is the central effector molecule of the complement system, mediating its multiple functions through different binding sites and their corresponding receptors. We will introduce the C3 forms (native C3, C3 [H2O], and intracellular C3), the C3 fragments C3a, C3b, iC3b, and C3dg/C3d, and the C3 expression sites.
Alessandra Zarantonello +3 more
openaire +3 more sources
, 2012 Complement C3 is the central component of the human complement system. It is ~186 kDa in size, consisting of an α-chain (~110 kDa) and a β-chain (~75 kDa) that are connected by cysteine bridges. C3 in its native form is inactive. Cleavage of C3 into C3b (~177 kDa) and C3a (~9 kDa) is a crucial step in the complement activation cascade, which can be ...
Dinasarapu, Ashok Reddy +3 more
core +3 more sources
Conformational Complexity of Complement Component C3 [PDF]
, 2007 The structures of native C3 and its major fragment C3c have provided a wealth of structural insights into the central protein of the complement system. The proteolytic activation steps, generating the important fragments C3b and iC3b, are thought to induce significant conformational changes in the molecule, yielding protein molecules with distinct ...
Janssen, B.J.C., Gros, P.
core +9 more sources
The complement C3 protein family in invertebrates [PDF]
Invertebrate Survival Journal, 2011 Complement C3 plays a pivotal role in the innate immune system of mammals as the central component of the complement system essential for its activation mechanism and effecter function.
M Nonaka
doaj +2 more sources
BMJ Open, 2021 Objectives Recently studies demonstrated that adipose tissue can produce and release complement C3 and serum complement C3 levels were associated with diabetes mellitus, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD).
Wei-Lin Wang, Ying Zhao, Limin Feng
doaj +1 more source
Development of a C3 humanized rat as a new model for evaluating novel C3 inhibitors
Journal of Innate Immunity, 2023 Introduction: C3 is central for all complement activation pathways, thus an attractive therapeutic target. Many C3-targeted agents are under extensive development with one already approved for clinical use.
Jin Chen +6 more
doaj +1 more source
Sanamed, 2022 Introduction: Burns, depending on the degree of severity, induce a significant pathophysiological response in the body. The complement system participates in the body's defenses as well as in immune responses after burn-induced trauma. Objectives: The
Arslanagic Selma, Karamehic Jasenko
doaj +1 more source
Crosstalk Between Activated Platelets and the Complement System [Elektronisk resurs]
, 2010 Several studies have shown that complement and thrombotic events co-exist. Platelets have been suspected to act as the bridge between the two cascade systems.
Hamad, Osama A., +3 more
core +8 more sources
A novel approach to immunoapheresis of C3a/C3 and proteomic identification of associates [PDF]
PeerJ, 2019 Background Complement factor C3 represents the central component of the complement cascade and its activation split product C3a plays an important role in inflammation and disease. Many human disorders are linked to dysregulation of the complement system
Wolfgang Winnicki +8 more
doaj +2 more sources