Results 21 to 30 of about 56,153 (264)
Cells, 2022 Shiga toxin (Stx)-producing Escherichia coli is the predominant offending agent of post-diarrheal hemolytic uremic syndrome (HUS), a rare disorder of microvascular thrombosis and acute kidney injury possibly leading to long-term renal sequelae.
Simona Buelli +12 more
doaj +1 more source
Crystal structure of 3-benzoyl-2-[(5-bromo-2-Hydroxy-3-methoxybenzylidene)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene [PDF]
, 2015 In the cyclohexene ring of the title compound, C23H20BrNO3S, the -(CH2)4- atoms are positionally disordered [occupancy ratio = 0.753 (6):0.247 (6)]. The ring has a half-chair conformation for both the major and minor components.
Byrappa, K. +5 more
core +3 more sources
Trithiacyanuric acid: a second triclinic polymorph [PDF]
, 2010 The title compound, C3H3N3S3, is a triclinic modification. The other reported modification crystallizes with just one molecule in the asymmetric unit, [Guo et al. (2006). Cryst. Growth Des.
Brito, Iván +2 more
core +2 more sources
Complement C3a activates astrocytes to promote medulloblastoma progression through TNF-α
Journal of Neuroinflammation, 2022 Background Medulloblastoma (MB) is the most common malignant brain tumor in children. Approximately one-third of MB patients remain incurable. Understanding the molecular mechanism of MB tumorigenesis is, therefore, critical for developing specific and ...
Biao Gong +9 more
doaj +1 more source
Kilogram scale synthesis of C3A polymorphs and their hydration reactions
Cement, 2023 Studies on the properties of pure C3A phases are often limited to methods requiring small sample amounts due to the lack of a convenient laboratory synthesis yielding sample amounts exceeding 100 g. Here, we report a simple and large scale lab method for
Daniel Axthammer +3 more
doaj +1 more source
Species-specific differences in regulation of macrophage inflammation by the C3a–C3a receptor axis [PDF]
Innate Immunity, 2018 Complement is an important arm of the innate immune system. Recent studies have shown that products of complement pathway activation can interact directly with other innate immune signaling molecules, including TLRs and inflammasome family members, during some infectious and chronic inflammatory disorders.
Ray, Tathagat Dutta +5 more
openaire +2 more sources
Virulence, 2019 The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Marcel Muenstermann +6 more
doaj +1 more source
Sulfation of Tyrosine 174 in the Human C3a Receptor Is Essential for Binding of C3a Anaphylatoxin [PDF]
Journal of Biological Chemistry, 2003 The complement anaphylatoxin C3a and its cellular seven-transmembrane segment receptor, C3aR, are implicated in a variety of pathological inflammatory processes. C3aR is a G-protein-coupled receptor with an exceptionally large second extracellular loop of 172 amino acids. Previously reported deletion studies have shown that at least part of this region
Jinming, Gao +5 more
openaire +2 more sources
Complement activation contributes to perioperative neurocognitive disorders in mice
Journal of Neuroinflammation, 2018 Background The complement system plays an important role in many neurological disorders. Complement modulation, including C3/C3a receptor signaling, shows promising therapeutic effects on cognition and neurodegeneration.
Chao Xiong +5 more
doaj +1 more source
A C3(H20) recycling pathway is a component of the intracellular complement system [PDF]
, 2017 An intracellular complement system (ICS) has recently been described in immune and nonimmune human cells. This system can be activated in a convertase-independent manner from intracellular stores of the complement component C3. The source of these stores
Botto +11 more
core +2 more sources