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C3a is made by proximal tubular HK-2 cells and activates them via the C3a receptor [PDF]
, 1999 C3a is made by proximal tubular HK-2 cells and activates them via the C3a receptor.BackgroundSome individual components of complement are synthesized by the kidney.
Pussell, Bruce A. +7 more
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C3aR plays both sides in regulating resistance to bacterial infections.
PLoS Pathogens, 2022 Activation of the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which interacts with membrane-bound receptor C3aR to regulate innate immune cell function and outcome of bacterial infection.
Jesse A Corcoran, Brooke A Napier
doaj +2 more sources
Kilogram scale synthesis of C3A polymorphs and their hydration reactions
Cement, 2023 Studies on the properties of pure C3A phases are often limited to methods requiring small sample amounts due to the lack of a convenient laboratory synthesis yielding sample amounts exceeding 100 g. Here, we report a simple and large scale lab method for
Daniel Axthammer +3 more
doaj +1 more source
, 2021 Urine samples obtained at consecutive time points from ICU patients suffering from serious infections. Patient (o) did not survive this episode due to multiorgan failure the same day as urine sample #5 was collected.
Sebastian Kapps (9979115) +7 more
core +1 more source
Complement activation contributes to perioperative neurocognitive disorders in mice
Journal of Neuroinflammation, 2018 Background The complement system plays an important role in many neurological disorders. Complement modulation, including C3/C3a receptor signaling, shows promising therapeutic effects on cognition and neurodegeneration.
Chao Xiong +5 more
doaj +1 more source
Virulence, 2019 The complement system is pivotal in the defense against invasive disease caused by Neisseria meningitidis (Nme, meningococcus), particularly via the membrane attack complex.
Marcel Muenstermann +6 more
doaj +1 more source
Scientific Reports, 2022 Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the production of a diverse array of autoantibodies and the dysfunctional activation of the complement system.
Yao-Hua Cai +6 more
doaj +1 more source
Bulletin of the National Research Centre, 2021 Background This study aimed to in vivo and in vitro evaluate the remineralization potential and shear bond strength (SBS) of experimentally prepared tri-calcium aluminate (C3A)-modified glass ionomer cements on sound and artificial caries-affected dentin
M. M. Radwan +2 more
doaj +1 more source
Effect of BaCO3 on C3A hydration [PDF]
, 2015 Ba ions are known to immobilise sulfates by forming BaSO4. The use of BaCO3 as a full or partial substitute for gypsum to regulate C3A (3CaO·Al2O3) hydration was consequently studied with a view to establishing its correct dosage in sulfate-resistant ...
Carmona-Quiroga, Paula +3 more
core +1 more source
ELISA-measurement of urinary complement factor C3a/C3 and C3a in 85 ICU patients.
, 2021 Data are presented in columned scatter graphs; the horizontal lines mark the mean values of the respective C3a/C3 (left) and C3a (right) levels. Day 1: n = 78; day 2: n = 78; day 3: n = 72; day 4: n = 66; day 5: n = 56; day 6: n = 48.
Sebastian Kapps (9979115) +7 more
core +1 more source