Results 121 to 130 of about 36,145 (228)
Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID
Immunology, Volume 178, Issue 2, Page 261-268, June 2026.The complement cascade, a series of blood proteins that assists in the recognition and neutralisation of pathogens, either independently or in conjunction with antibodies, is persistently activated in patients with long COVID. We found that blood plasma samples from patients with long COVID contained elevated concentrations of the mannan‐binding lectin‐
Samuel B. K. Keat +14 more
wiley +1 more source
Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS
Advanced Science, Volume 13, Issue 26, 8 May 2026.ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi +4 more
wiley +1 more source
Superantigen architecture: Functional decoration on a conserved scaffold [PDF]
, 2007 A defining and consistent feature of the bacterial superantigens from Staphylococcus aureus and Streptococcus pyogenes is their strongly conserved three-dimensional structure.
Arcus, Vickery L., Baker, Edward N.
core +1 more source
Targeting Tumor Stroma: Current Challenges and Future Directions
MedComm, Volume 7, Issue 5, May 2026.Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang +7 more
wiley +1 more source
Inactivation of the complement anaphylatoxin C5a by secreted products of parasitic nematodes
International Journal for Parasitology, 2010 Given the importance of the complement anaphylatoxins in cellular recruitment during infection, the ability of secreted products from larval stages of Brugia malayi and Trichinella spiralis to influence C5a-mediated chemotaxis of human peripheral blood granulocytes in vitro was examined. Secreted products from B.
Rees-Roberts, D +3 more
openaire +3 more sources
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Katharina A. Kälber +3 more
wiley +1 more source
Beyond feasibility filters: How expertise heterogeneity enables innovation recognition
Strategic Management Journal, Volume 47, Issue 5, Page 1368-1432, May 2026.Abstract Research Summary Organizations often struggle to identify promising innovations that balance novelty and feasibility in multidisciplinary domains, yet how does evaluator expertise heterogeneity shape these assessments? This study examines how evaluator expertise influences innovation evaluation through a field experiment with National ...
Jacqueline N. Lane +3 more
wiley +1 more source
Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma
Allergy, Volume 81, Issue 5, Page 1571-1586, May 2026.Complement activation module, particularly C5, is positively associated with eosinophilic inflammation in severe asthma cohorts. Elevated C5 expression correlates with poor lung function improvement and persistent eosinophilic inflammation. Mouse model studies confirm that C5 exacerbates eosinophilic inflammation, highlighting its potential as a ...
Cong Dong +217 more
wiley +1 more source