Results 31 to 40 of about 7,941 (204)

Tight Junctions of the Neurovascular Unit

Frontiers in Molecular Neuroscience, 2021
The homeostatic balance of the brain and retina is maintained by the presence of the blood-brain and inner blood-retinal barrier (BBB/iBRB, respectively) which are highly specialized barriers.
Natalie Hudson, Matthew Campbell
doaj   +1 more source

Africanized honeybee venom (Apis mellifera) promotes human complement activation split products storm

Frontiers in Immunology
IntroductionComplement activation split products are signatures of many immunopathological disorders. Among the laboratory findings observed in these diseases, a reduction in the level of circulating intact complement components can be mentioned, and ...
Felipe Silva de França, Felipe Silva de França, Ricardo de Oliveira Orsi, Dayanne Carla Fernandes, Dayanne Carla Fernandes, Thyago Bispo Leonel, Thyago Bispo Leonel, Denise V. Tambourgi, Denise V. Tambourgi   +8 more
doaj   +1 more source

Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment

mBio, 2018
Sepsis caused by Neisseria meningitidis (meningococcus) is a rapidly progressing, life-threatening disease. Because its initial symptoms are rather unspecific, medical attention is often sought too late, i.e., when the systemic inflammatory response is ...
Johannes B. Herrmann, Marcel Muenstermann, Lea Strobel, Alexandra Schubert-Unkmeir, Trent M. Woodruff, Scott D. Gray-Owen, Andreas Klos, Kay O. Johswich   +7 more
doaj   +1 more source

Immunological Hallmarks of Inflammatory Status in Vaso-Occlusive Crisis of Sickle Cell Anemia Patients

Frontiers in Immunology, 2021
Sickle Cell Anemia (SCA) is the most common genetic disorder around the world. The mutation in the β-globin gene is responsible for a higher hemolysis rate, with further involvement of immunological molecules, especially cytokines, chemokines, growth ...
Alexander Leonardo Silva-Junior, Alexander Leonardo Silva-Junior, Nadja Pinto Garcia, Evilázio Cunha Cardoso, Evilázio Cunha Cardoso, Stephanny Dias, Andrea Monteiro Tarragô, Andrea Monteiro Tarragô, Andrea Monteiro Tarragô, Nelson Abrahim Fraiji, Nelson Abrahim Fraiji, Matheus Souza Gomes, Laurence Rodrigues Amaral, Andréa Teixeira-Carvalho, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Olindo Assis Martins-Filho, Erich Vinicius De Paula, Erich Vinicius De Paula, Allyson Guimarães Costa, Allyson Guimarães Costa, Allyson Guimarães Costa, Allyson Guimarães Costa, Allyson Guimarães Costa, Allyson Guimarães Costa, Adriana Malheiro, Adriana Malheiro, Adriana Malheiro, Adriana Malheiro   +28 more
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Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

Complement Receptors and Their Role in Leukocyte Recruitment and Phagocytosis

Frontiers in Cell and Developmental Biology, 2021
The complement system is deeply embedded in our physiology and immunity. Complement activation generates a multitude of molecules that converge simultaneously on the opsonization of a target for phagocytosis and activation of the immune system via ...
Sofie Vandendriessche, Seppe Cambier, Paul Proost, Pedro E. Marques   +3 more
doaj   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

Functional modulation of human monocytes derived DCs by anaphylatoxins C3a and C5a

Immunobiology, 2012
Anaphylatoxins C3a and C5a are important modulators for dendritic cell activation and function in mice. In order to verify the significance of these observations in man, we have investigated the functional modulation of human monocytes derived DCs by C3a
Ke Li, H. Fazekasova, Naiyin Wang, Q. Peng, S. Sacks, G. Lombardi, Wuding Zhou   +6 more
semanticscholar   +1 more source

Complement Inhibition and COVID-19: The Story so Far

ImmunoTargets and Therapy, 2021
Sofiane Fodil,1 Djillali Annane1– 3 1Department of Intensive Care, Hôpital Raymond Poincaré (APHP), Garches, 92380, France; 2Laboratory of Infection & Inflammation _ U1173, School of Medicine Simone Veil, University Versailles Saint Quentin _ University ...
Fodil S, Annane D
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