Results 51 to 60 of about 7,925 (224)

Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF [PDF]

, 2016
Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture.
Espevik, Terje, Mollnes, Tom Eirik, Niyonzima, Nathalie, Nymo, Stig Haugset   +3 more
core   +3 more sources

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

A serine protease isolated from the bristles of the Amazonic caterpillar, Premolis semirufa, is a potent complement system activator. [PDF]

PLoS ONE, 2015
The caterpillar of the moth Premolis semirufa, commonly named pararama, is found in the Brazilian Amazon region. Accidental contact with the caterpillar bristles causes an intense itching sensation, followed by symptoms of an acute inflammation, which ...
Isadora Maria Villas Boas, Giselle Pidde-Queiroz, Fabio Carlos Magnoli, Rute M Gonçalves-de-Andrade, Carmen W van den Berg, Denise V Tambourgi   +5 more
doaj   +1 more source

Enhanced Fc and complement activity of Fc‐modified avelumab boosts anti‐tumor activity but promotes NK cell fratricide

Clinical &Translational Immunology, Volume 15, Issue 5, 2026.
Abstract Objectives The anti‐PD‐L1 antibody avelumab has demonstrated efficacy across multiple cancer types. Avelumab primarily blocks the PD‐1/L1 immune checkpoint, while inducing antibody‐dependent cellular cytotoxicity (ADCC) from CD16a+ NK cells.
Lachlan J Dobson, Barry D Hock, Ariana HT Drabble, Liping Goddard, Judith L McKenzie, Sean A MacPherson, Alexander D McLellan   +6 more
wiley   +1 more source

Bruton tyrosine kinase (Btk) in neutrophils is indispensable for initiating and maintaining skin inflammation in a model of pemphigoid diseases

British Journal of Pharmacology, Volume 183, Issue 10, Page 2446-2463, May 2026.
Background and Purpose Bruton tyrosine kinase (Btk) is essential for B cell function. Its role in myeloid cells is less understood. Greater insights into Btk significance in myeloid cells are needed to evaluate its potential as a therapeutic target during the effector phase of antibody‐induced autoimmune diseases, where inhibiting autoantibody ...
Henning Olbrich, Paul Schilf, Sripriya Murthy, Sina Gonther, Mareike Neumann, Christoph M. Hammers, Jasper N. Pruessmann, Christian D. Sadik   +7 more
wiley   +1 more source

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes

Clinical &Experimental Allergy, Volume 56, Issue 4, Page 344-368, April 2026.
ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M. F. Wiegman, Aurelie Poli, Joanna Jacków‐Malinowska, Jack Cheeseman, Daniel I. R. Spencer, James McDonnell, James Spicer, Alexandra J. McCraw, Sophia N. Karagiannis   +13 more
wiley   +1 more source

Complement System Inhibition Modulates the Pro-Inflammatory Effects of a Snake Venom Metalloproteinase

Frontiers in Immunology, 2019
Envenomation by Bothrops snakes causes prominent local effects, including pain, oedema, local bleeding, blistering and necrosis, and systemic manifestations, such as hemorrhage, hypotension, shock and acute renal failure.
Lygia Samartin Gonçalves Luchini, Giselle Pidde, Carla Cristina Squaiella-Baptistão, Denise V. Tambourgi   +3 more
doaj   +1 more source

Identification of candidate genes linking systemic inflammation to atherosclerosis; results of a human in vivo LPS infusion study. [PDF]

, 2011
BACKGROUND: It is widely accepted that atherosclerosis and inflammation are intimately linked. Monocytes play a key role in both of these processes and we hypothesized that activation of inflammatory pathways in monocytes would lead to, among others ...
Farrugia, Rosienne, Gusnanto, Arief, Langford, Cordelia F, Maiwald, Stephanie, Nieuwdorp, Max, Ouwehand, Willem H, Sivapalaratnam, Suthesh, Trip, Mieke D, van Beem, Rachel T, Watkins, Nicholas A, Zwaginga, Jaap Jan   +10 more
core   +5 more sources

Donor‐Derived Cell‐Free DNA (dd‐cfDNA) as an Early Noninvasive Biomarker of Graft Injury in Pig‐to‐Monkey Islet Xenotransplantation

Xenotransplantation, Volume 33, Issue 2, March/April 2026.
ABSTRACT Background In pig‐to‐nonhuman primate islet transplantation, reliable, sensitive biomarkers are needed to detect graft damage at an early stage before irreversible islet loss occurs. In our study, we investigated donor‐derived cell‐free DNA (dd‐cfDNA) as an early, noninvasive biomarker of graft injury by analyzing its correlation with porcine ...
Ji‐Jing Yan, Jong‐Min Kim, Sang‐Ik Cho, Hyori Kim, Kyungmin Kwak, Hyunil Kim, Eun‐Jee Oh, Jaeseok Yang, Chung‐Gyu Park, Jong Cheol Jeong, Beom Seok Kim   +10 more
wiley   +1 more source

Acute physiological changes caused by complement activators and amphotericin B-containing liposomes in mice

International Journal of Nanomedicine, 2019
Erik Őrfi,1,2 Tamás Mészáros,1,2 Mark Hennies,3 Tamás Fülöp,1,2 László Dézsi,1,2 Alexander Nardocci,1 László Rosivall,1,2 Péter Hamar,4,5 Barry W Neun,6 Marina A ...
Őrfi E, Mészáros T, Hennies M, Fülöp T, Dézsi L, Nardocci A, Rosivall L, Hamar P, Neun BW, Dobrovolskaia MA, Szebeni J, Szénási G   +11 more
doaj