Results 51 to 60 of about 5,613 (194)

Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance

Periodontology 2000, EarlyView.
Abstract Background Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent ...
Michael Wolf, Ulrike Schulze‐Späte, Thomas Van Dyke, Stefan Wolfart, Thomas Dietrich, Alberto Ortiz, Zhuojun Wu, Joachim Jankowski   +7 more
wiley   +1 more source

Pathophysiological changes in patients during hemodialysis and blood reinfusion predict potential development of hemodialysis reactions

Renal Failure
Hemodialysis reactions (HDRs) are a type of hypersensitivity reactions (HSRs), such as complement activation-related pseudoallergy (CARPA) observed during nanoparticle infusions.
Ákos Géza Pethő, Csaba Révész, Tamás Mészáros, Orsolya Sáfár, László Rosivall, József Domán, Gábor Szénási, Tünde Gigacz, László Dézsi   +8 more
doaj   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 9, Page 913-932, November 2026.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Anaphylatoxin C3a receptors in asthma [PDF]

Respiratory Research, 2005
AbstractThe complement system forms the central core of innate immunity but also mediates a variety of inflammatory responses. Anaphylatoxin C3a, which is generated as a byproduct of complement activation, has long been known to activate mast cells, basophils and eosinophils and to cause smooth muscle contraction.
Ali, Hydar, Panettieri, Reynold A.
openaire   +4 more sources

Emerging role of C5aR2: novel insights into the regulation of uterine immune cells during pregnancy

Frontiers in Immunology
Pregnancy is a fascinating immunological phenomenon because it allows allogeneic fetal and placental tissues to survive inside the mother. As a component of innate immunity with high inflammatory potential, the complement system must be tightly regulated
Fenna Froehlich, Konstanze Landerholm, Johanna Neeb, Ann-Kathrin Meß, Daniel Leonard Seiler, Tamara Tilburgs, Tamara Tilburgs, Christian Marcel Karsten   +7 more
doaj   +1 more source

Micrurus snake venoms activate human complement system and generate anaphylatoxins

BMC Immunology, 2012
Background The genus Micrurus, coral snakes (Serpentes, Elapidae), comprises more than 120 species and subspecies distributed from the south United States to the south of South America. Micrurus snake bites can cause death by muscle paralysis and further
Tanaka Gabriela D, Pidde-Queiroz Giselle, Furtado Maria de Fátima D, van den Berg Carmen, Tambourgi Denise V   +4 more
doaj   +1 more source

From Molecular Targets to Advanced Delivery Systems: Aptamers for Precision Ocular Therapeutics

Advanced Therapeutics, Volume 9, Issue 10, October 2026.
Aptamer‐based strategies are revolutionizing ocular disease management through highly specific molecular recognition of disease specific molecular targets. This review systematically integrates therapeutic aptamer sequences, diagnostic aptasensor platforms, and targeted delivery strategies, highlighting design principles, ocular bioavailability ...
Minal Thacker, Ka‐Ying Wong, Liping Zhou, Man‐Sau Wong, Juewen Liu   +4 more
wiley   +1 more source

Clinical analysis of selected complement-derived molecules in human adipose tissue

Journal of Translational Medicine, 2013
Background It has been suggested that action of complement cascade [CC]-derived anaphylatoxins/molecules may represent a missing link between obesity and metabolic disorders.
Błogowski Wojciech, Budkowska Marta, Sałata Daria, Serwin Karol, Dołęgowska Barbara, Łokaj Marek, Prowans Piotr, Starzyńska Teresa   +7 more
doaj   +1 more source

Cracking the cytokine code in sickle cell disease: Immune‐informatics for precision inflammation mapping, risk prediction and therapeutic discovery

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Sickle cell disease inflammation emerges from interconnected cytokine networks. Immune‐informatics integrates multi‐omics, network biology and artificial intelligence to decode inflammatory signatures, predict complications and identify precision therapeutic targets. Abstract Background Sickle cell disease (SCD) is characterised by chronic inflammation
Emmanuel Ifeanyi Obeagu, Chukwuma J. Okafor   +1 more
wiley   +1 more source

The pharmacophore of the human C5a anaphylatoxin [PDF]

Protein Science, 1994
AbstractWe have determined which amino acids contribute to the pharmacophore of human C5a, a potent inflammatory mediator. A systematic mutational analysis of this 74‐amino acid protein was performed and the effects on the potency of receptor binding and of C5a‐induced intracellular calcium ion mobilization were measured.
M J, Toth, L, Huwyler, W C, Boyar, A F, Braunwalder, D, Yarwood, J, Hadala, W O, Haston, M A, Sills, B, Seligmann, N, Galakatos   +9 more
openaire   +2 more sources