Results 51 to 60 of about 7,941 (204)

Complement System Inhibition Modulates the Pro-Inflammatory Effects of a Snake Venom Metalloproteinase

Frontiers in Immunology, 2019
Envenomation by Bothrops snakes causes prominent local effects, including pain, oedema, local bleeding, blistering and necrosis, and systemic manifestations, such as hemorrhage, hypotension, shock and acute renal failure.
Lygia Samartin Gonçalves Luchini, Giselle Pidde, Carla Cristina Squaiella-Baptistão, Denise V. Tambourgi   +3 more
doaj   +1 more source

Identification and validation of fecal complement component 3 and fibronectin as potential biomarkers for monitoring disease activity in ulcerative colitis based on a mouse model

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1292-1301, July 2026.
This study demonstrated elevated levels of fecal component 3 (C3) and fibronectin (FN) in an ulcerative colitis (UC) mouse model. Importantly, fecal C3 exhibited a stronger correlation with disease activity than the clinically used fecal calprotectin (FC).
Yangyun Guo, Ziheng Yan, Jingyu Ye, Ruifu Yang, Yajun Song, Hui Yue, Yong Zhao   +6 more
wiley   +1 more source

Acute physiological changes caused by complement activators and amphotericin B-containing liposomes in mice

International Journal of Nanomedicine, 2019
Erik Őrfi,1,2 Tamás Mészáros,1,2 Mark Hennies,3 Tamás Fülöp,1,2 László Dézsi,1,2 Alexander Nardocci,1 László Rosivall,1,2 Péter Hamar,4,5 Barry W Neun,6 Marina A ...
Őrfi E, Mészáros T, Hennies M, Fülöp T, Dézsi L, Nardocci A, Rosivall L, Hamar P, Neun BW, Dobrovolskaia MA, Szebeni J, Szénási G   +11 more
doaj  

Roles of Microglia in Cerebral Small Vessel Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Chronic cerebral hypoperfusion triggers microglial activation in cerebral small vessel disease (CSVD). Activated microglia drive neuroinflammation, oxidative stress, and blood–brain barrier disruption, leading to white matter hyperintensities, enlarged perivascular spaces, and other neuroimaging features.
Chenyang Jin, Xiaoqian Song, Yuewen Sun, Yilong Peng, Jing Zhou, Liyan Wang, Xinbao Yin, Xueping Zheng   +7 more
wiley   +1 more source

Anaphylaxis and Anaphylatoxins

In the study of the phenomena of anaphylaxis there are certain points on which some measure of agreement seems to have been attained. In the case of anaphylaxis to soluble proteins, with which alone we are directly concerned in this paper, the majority ...
H. Dale, C. Kellaway
semanticscholar   +1 more source

Pathophysiological changes in patients during hemodialysis and blood reinfusion predict potential development of hemodialysis reactions

Renal Failure
Hemodialysis reactions (HDRs) are a type of hypersensitivity reactions (HSRs), such as complement activation-related pseudoallergy (CARPA) observed during nanoparticle infusions.
Ákos Géza Pethő, Csaba Révész, Tamás Mészáros, Orsolya Sáfár, László Rosivall, József Domán, Gábor Szénási, Tünde Gigacz, László Dézsi   +8 more
doaj   +1 more source

Anaphylatoxins in preterm and term labor [PDF]

Journal of Perinatal Medicine, 2005
The complement system plays a central role in the first line of defense against invading pathogens, and its activation involves the release of potent pro-inflammatory mediators such as anaphylatoxins C3a, C4a and C5a. The aim of this study was to determine whether differences existed in maternal plasma anaphylatoxin concentrations between patients with
Eleazar, Soto, Roberto, Romero, Karina, Richani, Jimmy, Espinoza, Jyh Kae, Nien, Tinnakorn, Chaiworapongsa, Joaquin, Santolaya-Forgas, Samuel S, Edwin, Moshe, Mazor   +8 more
openaire   +2 more sources

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni, Ebba Qviberg, Edward Chaloner, Hayley Lavender, Maisem Laabei   +4 more
wiley   +1 more source

Emerging role of C5aR2: novel insights into the regulation of uterine immune cells during pregnancy

Frontiers in Immunology
Pregnancy is a fascinating immunological phenomenon because it allows allogeneic fetal and placental tissues to survive inside the mother. As a component of innate immunity with high inflammatory potential, the complement system must be tightly regulated
Fenna Froehlich, Konstanze Landerholm, Johanna Neeb, Ann-Kathrin Meß, Daniel Leonard Seiler, Tamara Tilburgs, Tamara Tilburgs, Christian Marcel Karsten   +7 more
doaj   +1 more source

Clinical analysis of selected complement-derived molecules in human adipose tissue

Journal of Translational Medicine, 2013
Background It has been suggested that action of complement cascade [CC]-derived anaphylatoxins/molecules may represent a missing link between obesity and metabolic disorders.
Błogowski Wojciech, Budkowska Marta, Sałata Daria, Serwin Karol, Dołęgowska Barbara, Łokaj Marek, Prowans Piotr, Starzyńska Teresa   +7 more
doaj   +1 more source