Results 21 to 30 of about 7,941 (204)
Renal Failure, 2021 Hemodialysis reactions (HDRs) resemble complement-activation-related pseudoallergy (CARPA) to certain i.v. drugs, for which pigs provide a sensitive model. On this basis, to better understand the mechanism of human HDRs, we subjected pigs to hemodialysis
Ákos Pethő +11 more
doaj +1 more source
Complement System: Promoter or Suppressor of Cancer Progression?
Antibodies, 2020 Constituent of innate immunity, complement is present in the tumor microenvironment. The functions of complement include clearance of pathogens and maintenance of homeostasis, and as such could contribute to an anti-tumoral role in the context of certain
Margot Revel +4 more
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Complement anaphylatoxins C3a and C5a: Emerging roles in cancer progression and treatment.
Seminars in Cell and Developmental Biology, 2017 Recent insights into the role of complement anaphylatoxins C3a and C5a in cancer provide new opportunities for the development of innovative biomarkers and therapeutic strategies. These two complement activation products can maintain chronic inflammation,
D. Ajona, S. Ortiz-Espinosa, R. Pio
semanticscholar +1 more source
PROTEOTOXINS (ANAPHYLATOXINS) AND VIRULENCE [PDF]
Journal of Experimental Medicine, 1914 1. Our experiments show that proteotoxin (anaphylatoxin) produced with typhoid bacilli and active guinea pig serum, by the general method of Friedberger, possesses aggressin-like action in that, when injected together with sublethal doses of bacteria, it renders them lethal. 2. This action is not specific, since even when typhoid bacilli
H, Zinsser, J G, Dwyer
openaire +2 more sources
Complement 3a and Complement 5a as Biochemical Markers in Diabetic Nephropathy [PDF]
International Journal of Medical ArtsBackground: Diabetes mellitus [DM] is growing into a global epidemic and diabetic nephropathy [DN] is one of its most feared complications. Inflammation is an important mechanism in the pathogenesis of DN and many studies have pointed to anaphylatoxins ...
Safwat Ahmed +3 more
doaj +1 more source
Role of Complement and Histones in Sepsis
Frontiers in Medicine, 2020 The wide use of the mouse model of polymicrobial sepsis has provided important evidence for events occurring in infectious sepsis involving septic mice and septic humans.
Firas S. Zetoune, Peter A. Ward
doaj +1 more source
P-I snake venom metalloproteinase is able to activate the complement system by direct cleavage of central components of the cascade. [PDF]
PLoS Neglected Tropical Diseases, 2013 BACKGROUND: Snake Venom Metalloproteinases (SVMPs) are amongst the key enzymes that contribute to the high toxicity of snake venom. We have recently shown that snake venoms from the Bothrops genus activate the Complement system (C) by promoting direct ...
Giselle Pidde-Queiroz +7 more
doaj +1 more source
Critical Care, 2021 Background Thrombosis and coagulopathy are highly prevalent in critically ill patients with COVID-19 and increase the risk of death. Immunothrombosis has recently been demonstrated to contribute to the thrombotic events in COVID-19 patients with ...
Yue Zhang +7 more
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The Role of the Anaphylatoxins in Health and Disease
Molecular Immunology, 2009 The anaphylatoxins (AT) C3a, C5a and C5a-desArg are generally considered pro-inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to complement activation.
A. Klos +5 more
semanticscholar +1 more source
ON ANAPHYLATOXINS AND ENDOTOXINS OF THE TYPHOID BACILLUS
Journal of Experimental Medicine, 1913 The experiments recorded in this paper confirm the observations of Friedberger that acutely toxic bodies can be produced from typhoid bacilli by the action of sensitizer and complement and that, when small quantities of bacteria are used, an excess of ...
H. Zinsser
semanticscholar +1 more source