Results 21 to 30 of about 7,925 (224)

Loss of very-long O-antigen chains optimizes capsule-mediated immune evasion by Salmonella enterica serovar Typhi. [PDF]

, 2013
UnlabelledExpression of capsular polysaccharides is a variable trait often associated with more-virulent forms of a bacterial species. For example, typhoid fever is caused by the capsulated Salmonella enterica serovar Typhi, while nontyphoidal Salmonella
Bäumler, Andreas J, Crawford, Robert W, Spees, Alanna M, Tsolis, Renée M, Wangdi, Tamding, Xavier, Mariana N   +5 more
core   +1 more source

Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins

Frontiers in Immunology, 2021
Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus   +8 more
doaj   +1 more source

Complement in the homeostatic and ischemic brain [PDF]

, 2015
The complement system is a component of the immune system involved in both recognition and response to pathogens, and it is implicated in an increasing number of homeostatic and disease processes. It is well documented that reperfusion of ischemic tissue
Aivazian, Akita, Alexander, Amara, Arumugam, Atkinson, Austen, Barber, Barber, Bednar, Beek, Bellander, Benard, Benard, Benoit, Boos, Busche, Carmichael, Carmichael, Carmichael, Cavusoglu, Cervera, Chu, Cojocaru, Costa, Cowell, Crane, Cudrici, Davoust, De La Rosa, De Simoni, De Simoni, Di Napoli, Ducruet, Ducruet, Ducruet, Ducruet, Elvington, Elvington, Engstrom, Figueroa, Fisher, Frauenknecht, Garrett, Gasque, Gasque, Gesuete, Gill, Harboe, Harhausen, Heese, Heimann, Hoke, Holers, Huang, Huber-Lang, Hurtado, Iadecola, Imm, Jauneau, Katzan, Kim, Kramer, Kulik, Levi-Strauss, Lew, Li, Li, Lindsberg, Luo, Mack, McMullen, Mead, Mehta, Mocco, Mocco, Mocco, Moriyama, Morrison, Mukherjee, Mukherjee, Murphy, Olsson, Orsini, Osaka, Osthoff, Patel, Pavlovski, Pedersen, Pedersen, Pedersen, Persson, Pisalyaput, Rahpeymai, Ramaglia, Ricklin, Rogers, Rupprecht, Rynkowski, Schafer, Schafer, Schultz, Shinjyo, Soane, Somani, Speidl, Stahel, Stephan, Stevens, Stokowska, Stokowska, Storini, Széplaki, Ten, Ten, Thundyil, Thurman, Tohgi, Van Beek, Vasthare, Wieloch, Williams, Yang, Zee, Zhang, Zhang, Zhang, Zhang, Zhang, Zipfel   +129 more
core   +3 more sources

Complement 3a and Complement 5a as Biochemical Markers in Diabetic Nephropathy [PDF]

International Journal of Medical Arts
Background: Diabetes mellitus [DM] is growing into a global epidemic and diabetic nephropathy [DN] is one of its most feared complications. Inflammation is an important mechanism in the pathogenesis of DN and many studies have pointed to anaphylatoxins ...
Safwat Ahmed, Alsayed Alsayed, Mohammed Aref, Ahmad Alkot   +3 more
doaj   +1 more source

The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]

, 2018
The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J, Graves, Edward E, Kim, Ryan K, Melemenidis, Stavros, Olcina, Monica M   +4 more
core   +1 more source

Role of Complement and Histones in Sepsis

Frontiers in Medicine, 2020
The wide use of the mouse model of polymicrobial sepsis has provided important evidence for events occurring in infectious sepsis involving septic mice and septic humans.
Firas S. Zetoune, Peter A. Ward
doaj   +1 more source

P-I snake venom metalloproteinase is able to activate the complement system by direct cleavage of central components of the cascade. [PDF]

PLoS Neglected Tropical Diseases, 2013
BACKGROUND: Snake Venom Metalloproteinases (SVMPs) are amongst the key enzymes that contribute to the high toxicity of snake venom. We have recently shown that snake venoms from the Bothrops genus activate the Complement system (C) by promoting direct ...
Giselle Pidde-Queiroz, Fábio Carlos Magnoli, Fernanda C V Portaro, Solange M T Serrano, Aline Soriano Lopes, Adriana Franco Paes Leme, Carmen W van den Berg, Denise V Tambourgi   +7 more
doaj   +1 more source

Renal C3 complement component: feed forward to diabetic kidney disease [PDF]

, 2015
BACKGROUND: Diabetic nephropathy is the main cause of end-stage renal disease and has reached epidemic proportions. METHODS: Comprehensive genomic profiling (RNAseq) was employed in the ZS (F1 hybrids of Zucker and spontaneously hypertensive heart ...
Dominguez, Jesus H., Kelly, Katherine J., Liu, Yunlong, Zhang, Jizhong   +3 more
core   +2 more sources

PROTEOTOXINS (ANAPHYLATOXINS) AND VIRULENCE [PDF]

Journal of Experimental Medicine, 1914
1. Our experiments show that proteotoxin (anaphylatoxin) produced with typhoid bacilli and active guinea pig serum, by the general method of Friedberger, possesses aggressin-like action in that, when injected together with sublethal doses of bacteria, it renders them lethal. 2. This action is not specific, since even when typhoid bacilli
H, Zinsser, J G, Dwyer
openaire   +2 more sources

Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients

Critical Care, 2021
Background Thrombosis and coagulopathy are highly prevalent in critically ill patients with COVID-19 and increase the risk of death. Immunothrombosis has recently been demonstrated to contribute to the thrombotic events in COVID-19 patients with ...
Yue Zhang, Kai Han, Chunjing Du, Rui Li, Jingyuan Liu, Hui Zeng, Liuluan Zhu, Ang Li   +7 more
doaj   +1 more source