Results 11 to 20 of about 5,613 (194)
Requirements for membrane attack complex formation and anaphylatoxins binding to collagen-activated platelets. [PDF]
PLoS ONE, 2011 The activation of complement during platelet activation is incompletely understood.We sought to explore the formation of C5b-9 and anaphylatoxins binding to collagen-activated platelets.C5b-9, anaphylatoxins C3a, C4a and C5a, and anaphylatoxin receptors ...
Catherine Martel +6 more
doaj +3 more sources
Anaphylatoxins in organ transplantation
Seminars in Immunology, 2013 C3a and C5a (also called anaphylatoxins) are inflammatory peptides generated during complement activation. They do not only play important roles in innate immunity through the initiation and regulation of inflammatory responses, but also significantly influence adaptive immune responses.
Li, Ke, Zhou, Wuding
openaire +4 more sources
C3a and C5a plasma concentrations in patients with diabetic retinopathy: a cross-sectional study [PDF]
International Journal of Retina and VitreousBackground Diabetic retinopathy (DR) is the leading cause of irreversible blindness in adults, with inflammation playing a critical role in its pathogenesis, particularly involving the complement system (CS). Components of the complement cascade, such as
Paula Basso Dias +4 more
doaj +2 more sources
Anaphylatoxins inhibit C2 production
, 1983 Anaphylatoxins C5a and C3a and their des Arg derivatives inhibited C2 production by mononuclear phagocytes. C5a and C5adesArg which were approximately equipotent (IC50 = 10(-10) mol/l) were more effective than C3a (IC50 = 5 X 10(-8) mol/l) which was ...
Lappin, D., Whaley, K., Damerau, B.
core +8 more sources
Interleukin-33 amplifies human mast cell activities induced by complement anaphylatoxins
, 2020 Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Wileman, Georgia +8 more
core +11 more sources
PLoS Neglected Tropical Diseases, 2021 The complement system is activated in tuberculous pleural effusion (TPE), with increased levels of the anaphylatoxins stimulating pleural mesothelial cells (PMCs) to secrete chemokines, which recruit nonclassical monocytes to the pleural cavity.
Shuanglinzi Deng +8 more
doaj +1 more source
Modulation of Neutrophil Activity by Soluble Complement Cleavage Products—An In-Depth Analysis
Cells, 2022 The cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors.
Lisa Wohlgemuth +14 more
doaj +1 more source
Biomedicines, 2023 The liver has a huge impact on the functioning of our body and the preservation of homeostasis. It is exposed to many serious diseases, which may lead to the chronic failure of this organ, which is becoming a global health problem today.
Marta Budkowska +11 more
doaj +1 more source
Biomedicines, 2021 Activation of the complement system is important for efficient clearance of a wide variety of pathogens via opsonophagocytosis, or by direct lysis via complement-dependent cytotoxicity (CDC).
Carolin Schmidt +8 more
doaj +1 more source
Role of the Complement System in the Modulation of T-Cell Responses in Chronic Chagas Disease
Frontiers in Cellular and Infection Microbiology, 2022 Chagas disease, caused by the intracellular pathogen Trypanosoma cruzi, is the parasitic disease with the greatest impact in Latin America and the most common cause of infectious myocarditis in the world.
María Belén Caputo +6 more
doaj +1 more source