Results 11 to 20 of about 7,925 (224)

Complement activation during cardiopulmonary bypass and association with clinical outcomes

eJHaem, 2022
In this prospective, single‐centre observational study of 30 patients undergoing cardiopulmonary bypass (CPB), the effect of unfractionated heparin (UFH), CPB surgery and protamine sulphate on complement and on post‐operative blood loss were assessed ...
Rengina Kefalogianni, Farah Kamani, Mihaela Gaspar, TC Aw, Jackie Donovan, Mike Laffan, Matthew C. Pickering, Deepa J. Arachchillage   +7 more
doaj   +1 more source

ColdZyme Maintains Integrity in SARS-CoV-2-Infected Airway Epithelia

mBio, 2021
SARS-CoV-2 infection causing the COVID-19 pandemic calls for immediate interventions to avoid viral transmission, disease progression, and subsequent excessive inflammation and tissue destruction. Primary normal human bronchial epithelial cells are among
W. Posch, J. Vosper, V. Zaderer, A. Noureen, S. Constant, R. Bellmann-Weiler, C. Lass-Flörl, D. Wilflingseder   +7 more
doaj   +1 more source

Anaphylatoxin Complement 5a in Pfizer BNT162b2-Induced Immediate-Type Vaccine Hypersensitivity Reactions

Vaccines, 2023
The underlying immunological mechanisms of immediate-type hypersensitivity reactions (HSR) to COVID-19 vaccines are poorly understood. We investigate the mechanisms of immediate-type hypersensitivity reactions to the Pfizer BNT162b2 vaccine and the ...
Xin Rong Lim, Grace Yin Lai Chan, Justina Wei Lynn Tan, Carol Yee Leng Ng, Choon Guan Chua, Guat Bee Tan, Stephrene Seok Wei Chan, Kiat Hoe Ong, Ying Zhi Tan, Sarah Hui Zhen Tan, Claire Min Li Teo, Samuel Shang Ming Lee, Bernard Yu Hor Thong, Bernard Pui Lam Leung   +13 more
doaj   +1 more source

Interleukin-1β and anaphylatoxins exert a synergistic effect on NGF expression by astrocytes

Journal of Neuroinflammation, 2006
C3a and C5a anaphylatoxins are proinflammatory polypeptides released during complement activation. They exert their biological activities through interaction with two G protein-coupled receptors named C3aR and C5aR, respectively.
Patte Christine, Schouft Marie-therese, Chan Philippe, Benard Magalie, Chatagner Alexandra, Ischenko Alexander, Jauneau Anne-christine, Vaudry Hubert, Fontaine Marc   +8 more
doaj   +1 more source

A porcine model of hemodialyzer reactions: roles of complement activation and rinsing back of extracorporeal blood

Renal Failure, 2021
Hemodialysis reactions (HDRs) resemble complement-activation-related pseudoallergy (CARPA) to certain i.v. drugs, for which pigs provide a sensitive model. On this basis, to better understand the mechanism of human HDRs, we subjected pigs to hemodialysis
Ákos Pethő, Dorothea Piecha, Tamás Mészáros, Rudolf Urbanics, Christoph Moore, Bernard Canaud, László Rosivall, Tom Eirik Mollnes, Sonja Steppan, Gábor Szénási, János Szebeni, László Dézsi   +11 more
doaj   +1 more source

Complement System: Promoter or Suppressor of Cancer Progression?

Antibodies, 2020
Constituent of innate immunity, complement is present in the tumor microenvironment. The functions of complement include clearance of pathogens and maintenance of homeostasis, and as such could contribute to an anti-tumoral role in the context of certain
Margot Revel, Marie V. Daugan, Catherine Sautés-Fridman, Wolf H. Fridman, Lubka T. Roumenina   +4 more
doaj   +1 more source

Anaphylatoxin and Anaphylaxis: I. Trypanosome Anaphylatoxin [PDF]

Journal of Infectious Diseases, 1917
FOREWORD METHODS EMPLOYED AttAPHYLATOXIN-PRODUCTION WITH : SURRA TRYPANOSOME (T. EVAN SI) CADERAS TRYPANOSOME (t. EQUINUM) DOURINE TRYPANOSOME (T. EQUIPERDUM) TRYPANOSOMA LEWISI SERIAL PRODUCTION NAGANA TRYPANOSOME (t. BRUCEl) GUINEA-PIG SERUM ; SERIAL PRODUCTION J TOXIC WAVE.
F. G. Novy, P. H. DeKruif, R. L. Novy
openaire   +1 more source

An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. [PDF]

, 2015
Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells.
Fishbein, MC, Gjertson, D, Mulder, A, Panicker, S, Parry, GC, Reed, EF, Thomas, KA, Valenzuela, NM   +7 more
core   +1 more source

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions. [PDF]

Compr Physiol
Local complement production by pulmonary artery adventitial fibroblasts, activated intracellularly by CFD and CFB and extracellularly by GZMK+ CD8 T cells, and its secretion in soluble form and within EVs promotes macrophage and T cell chemotaxis and activation.
Zhang H, Prasad RR, Kumar S, Li M, Jones D, Hu CJ, Mickael C, Yu YR, Tuder RM, Stenmark KR.   +9 more
europepmc   +2 more sources

Complement System Part II: Role in Immunity [PDF]

, 2015
International audienceThe complement system has been considered for a long time as a simple lytic cascade, aimed to kill bacteria infecting the host organism.
Fremeaux-Bacchi, Veronique, Halbwachs-Mecarelli, Lise, Merle, Nicolas S., Noe, Remi, Roumenina, Lubka T.   +4 more
core   +8 more sources