Results 11 to 20 of about 389,834 (185)

Detection of both isotypes of complement C4, C4A and C4B, in normal human glomeruli [PDF]

Kidney International, 1986
Monoclonal antibodies reactive against the complement C4A and C4B isotypic components were used in an immunoperoxidase technique for the histological study of normal human renal tissue. Prominent staining with both antibodies was seen in the mesangial areas of all normal kidney sections investigated.
Feucht, Helmut E., Jung, Christina M., Gokel, Michael J., Riethmüller, Gert, Zwirner, Jörg, Brase, Angelika, Held, Eckhard, O'Neill, Geoffrey J.   +7 more
openaire   +3 more sources

Heterogeneity in the structural basis of the human complement C4A null allele (C4A*Q0) as revealed by HindIII restriction fragment length polymorphism analysis [PDF]

FEBS Letters, 1987
The highly polymorphic fourth component of human complement (C4) is usually encoded by two genes, C4A and C4B, adjacent to the 21‐hydroxylase (21‐OH) genes, 21‐OHA and 21‐OHB, and is also remarkable in the high frequency of the ‘null’ alleles, C4A*Q0 and C4B*Q0.
Uring-Lambert, Béatrice, Vegnaduzzi, Nathalie, Carroll, Michael C., Tongio, Marie-Marthe, Goetz, Joëlle, Hauptmann, Georges   +5 more
openaire   +4 more sources

Increase in Comforting Behavior (Allogrooming) During Social Interaction in Male Mice Deficient for the Slp Gene of Complement Component C4 [PDF]

Brain Sciences
Background: Oxytocin (OT) is a nonapeptide hormone produced in the hypothalamus, released into the brain and peripheral circulation, and plays a key role in social behavior.
Yasuhiko Yamamoto, Anpei Zhang, Anna A. Shabalova, Ai Harashima, Kyota Fujita, Teruko Yuhi, Yu Oshima, Pinyue Fu, Sei-ichi Munesue, Kana Minami, Kazuhiro Higashida, Hirokazu Kumazaki, Chiharu Tsuji, Haruhiro Higashida   +13 more
doaj   +2 more sources

Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C. [PDF]

World J Hepatol, 2013
To evaluate serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C virus (HCV) infection.The study included 30 children with chronic HCV infection before receiving antiviral therapy. Chronic HCV infection was defined by positive anti-HCV, a positive polymerase chain reaction for HCV-RNA for more than 6 mo with ...
Behairy BE, El-Mashad GM, Abd-Elghany RS, Ghoneim EM, Sira MM.   +4 more
europepmc   +3 more sources

Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures [PDF]

BMC Medicine
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is common among midlife women. Circulating extracellular vesicles (EVs) carry bioactive cargo that may mediate or reflect disease processes, but their role in hepatic steatosis ...
Patrick Pirrotte, Brooke Lovell, Siobán D. Harlow, Carrie A. Karvonen-Gutierrez, Michelle M. Hood, Ignazio S. Piras, Xiumei Wu, Melissa N. Martinez, Ritin Sharma, Krystine Garcia-Mansfield, Maya Willey, Johanna K. DiStefano   +11 more
doaj   +2 more sources

Correction: Copy Number Analysis of Complement C4A, C4B and C4A Silencing Mutation by Real-Time Quantitative Polymerase Chain Reaction

PLoS ONE, 2012
There was an error in the Competing Interests statement. The correct Competing interests are: MLL is working as a consultant at a company owned by the University of Helsinki providing complement C4 analysis for diagnostic samples. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The other authors
Paakkanen, Riitta, Vauhkonen, Hanna, Eronen, Katja T., Järvinen, Asko, Seppänen, Mikko, Lokki, Marja-Liisa   +5 more
doaj   +4 more sources

Low Copy Numbers of Complement C4 and C4A Deficiency Are Risk Factors for Myositis, Its Subgroups and Autoantibodies [PDF]

, 2022
Background Idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterized by myositis-related autoantibodies plus infiltration of leukocytes into muscles and/or the skin, leading to destruction of blood vessels and muscle ...
Lamb, Janine; id_orcid, Payton, Antony; id_orcid, Chinoy, Hector; id_orcid, Ollier, William, Rothwell, Simon; id_orcid, et al.   +5 more
core   +2 more sources

Increased activation product of complement 4 protein in plasma of individuals with schizophrenia

Translational Psychiatry, 2021
Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression.
Agnieszka Kalinowski, Joanna Liliental, Lauren A. Anker, Omer Linkovski, Collin Culbertson, Jacob N. Hall, Reenal Pattni, Chiara Sabatti, Douglas Noordsy, Joachim F. Hallmayer, Elizabeth D. Mellins, Jacob S. Ballon, Ruth O’Hara, Douglas F. Levinson, Alexander E. Urban   +14 more
doaj   +1 more source

Changes in complement activation products after anti-VEGF injection for choroidal neovascularization in age-related macular degeneration and pachychoroid disease

Scientific Reports, 2021
We evaluated changes in the complement system resulting from anti-vascular endothelial growth factor (VEGF) in eyes with age-related choroidal neovascularization (CNV) including neovascular age-related macular degeneration, pachychoroid neovasculopathy ...
Keiichiro Tanaka, Yasuharu Oguchi, Tomoko Omori, Yumi Ishida, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu   +13 more
doaj   +1 more source

Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth

Genome Biology, 2023
Background Increased expression of the complement component 4A (C4A) gene is associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in synaptic pruning; yet, it remains unclear the extent to which upregulation of C4A ...
Leanna M. Hernandez, Minsoo Kim, Pan Zhang, Richard A. I. Bethlehem, Gil Hoftman, Robert Loughnan, Diana Smith, Susan Y. Bookheimer, Chun Chieh Fan, Carrie E. Bearden, Wesley K. Thompson, Michael J. Gandal   +11 more
doaj   +1 more source