Results 11 to 20 of about 11,655 (197)

Complement C4, C4A and C4a – What they do and how they differ

Brain, Behavior, & Immunity - Health
Meike Heurich, Melanie Focking, David Cotter   +2 more
exaly   +7 more sources

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction. [PDF]

PLoS ONE, 2012
Low protein levels and copy number variation (CNV) of the fourth component of human complement (C4A and C4B) have been associated with various diseases. High-throughput methods for analysing C4 CNV are available, but they commonly do not detect the most ...
Riitta Paakkanen, Hanna Vauhkonen, Katja T Eronen, Asko Järvinen, Mikko Seppänen, Marja-Liisa Lokki   +5 more
doaj   +5 more sources

Real-time PCR quantification of human complement C4A and C4B genes [PDF]

BMC Genetics, 2006
Background The fourth component of human complement (C4), an essential factor of the innate immunity, is represented as two isoforms (C4A and C4B) in the genome.
Fust George, Szilassy Denes, Blasko Bernadett, Szilagyi Agnes, Sasvari-Szekely Maria, Ronai Zsolt   +5 more
doaj   +3 more sources

Complement Cascades and Brain Disorders [PDF]

Biomolecules
The complement system is a vital component of innate immunity. Besides its roles in pathogen defense, its significance in neurodevelopment, neurodegeneration, and cancer progression is beginning to be recognized.
Ivana Jovčevska, Alja Videtič Paska, Katarina Kouter   +2 more
doaj   +2 more sources

Proteomic and In Silico Analyses Highlight Complement System’s Role in Bladder Cancer Immune Regulation [PDF]

Medicina
Background and Objectives: Bladder cancer (BLCA), intimately associated with the immune system, represents a substantial global health burden due to its high recurrence rates and limited therapeutic effectiveness.
Tuğcan Korak, İbrahim Halil Baloğlu, Murat Kasap, Elif Damla Arisan, Gurler Akpinar, Serdar Arisan   +5 more
doaj   +2 more sources

Distinct Effects of Complement C4A and C4B Copy Numbers in Systemic Sclerosis Serological and Clinical Subtypes. [PDF]

Arthritis Rheumatol
Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. The variable copy number (CN) of C4 genes and retroviral human endogenous retrovirus K (HERV‐K) element influence its function.
Martínez-López J, Rangel-Peláez C, Rodriguez-Martin I, Guillen-Del-Castillo A, Simeón-Aznar CP, Callejas JL, Distler O, International SSc Group, PRECISESADs Clinical Consortium, Proudman SM, Nikpour M, Australian Scleroderma Interest Group (ASIG), Hunzelmann N, Moroncini G, de Vries-Bouwstra JK, Herrick AL, Allanore Y, Alarcon-Riquelme ME, Beretta L, Assassi S, Denton CP, Mayes MD, Martin J, Acosta-Herrera M, Kerick M.   +24 more
europepmc   +2 more sources

Complement factor C4a does not activate protease‐activated receptor 1 (PAR1) or PAR4 on human platelets

Research and Practice in Thrombosis and Haemostasis, 2021
Background Protease‐activated receptor (PAR) 1 and PAR4 are key thrombin signal mediators for human platelet activation and aggregation in response to vascular injury.
Xu Han, Maria de la Fuente, Marvin T. Nieman   +2 more
doaj   +1 more source

Increased activation product of complement 4 protein in plasma of individuals with schizophrenia

Translational Psychiatry, 2021
Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression.
Agnieszka Kalinowski, Joanna Liliental, Lauren A. Anker, Omer Linkovski, Collin Culbertson, Jacob N. Hall, Reenal Pattni, Chiara Sabatti, Douglas Noordsy, Joachim F. Hallmayer, Elizabeth D. Mellins, Jacob S. Ballon, Ruth O’Hara, Douglas F. Levinson, Alexander E. Urban   +14 more
doaj   +1 more source

Changes in complement activation products after anti-VEGF injection for choroidal neovascularization in age-related macular degeneration and pachychoroid disease

Scientific Reports, 2021
We evaluated changes in the complement system resulting from anti-vascular endothelial growth factor (VEGF) in eyes with age-related choroidal neovascularization (CNV) including neovascular age-related macular degeneration, pachychoroid neovasculopathy ...
Keiichiro Tanaka, Yasuharu Oguchi, Tomoko Omori, Yumi Ishida, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu   +13 more
doaj   +1 more source

Novel potential interacting partners of fibronectin in spontaneous animal model of interstitial cystitis [PDF]

, 2012
Feline idiopathic cystitis (FIC) is the only spontaneous animal model for human interstitial cystitis (IC), as both possess a distinctive chronical and relapsing character. Underlying pathomechanisms of both diseases are not clearly established yet.
Amann, Barbara, Deeg, Cornelia A., Dorsch, Roswitha, Euler, Kerstin N., Hartmann, Katrin, Hauck, Stefanie M., Treutlein, Gudrun   +6 more
core   +5 more sources