Restriction fragment analysis of duplication of the fourth component of complement (C4A)
Genomics, 1988 The two genes encoding the fourth component of complement (C4A and C4B) reside between HLA-B and HLA-DR on human chromosome 6. Two kilobases downstream from each C4 gene lies a 21-hydroxylase gene (CA21HA and CA21HB, respectively). Utilizing the method of Southern blotting and a 5'-end 2.4-kb BamHI/KpnI fragment of the C4 cDNA, we have analyzed TaqI ...
R H, McLean +5 more
openaire +2 more sources
Ophthalmology Science, 2022 Purpose: To investigate the association of risk alleles in complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) with complement activation products in the aqueous humor in eyes with neovascular age-related macular degeneration ...
Yutaka Kato, MD +11 more
doaj +1 more source
An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. [PDF]
, 2015 Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells.
Fishbein, MC +7 more
core +1 more source
Advances in Rheumatology, 2019 Background Complement component 4 (C4) gene copy number (GCN) affects the susceptibility to systemic lupus erythematosus (SLE) in different populations, however the possible phenotype significance remains to be determined.
Kaline Medeiros Costa Pereira +7 more
doaj +1 more source
A study of the association of HLA DR, DQ, and complement C4 alleles with systemic lupus erythematosus in Iceland [PDF]
, 2009 To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldOBJECTIVE: To perform an exploratory analysis of the relative contribution of single MHC genes to the pathogenesis of systemic lupus ...
Arason, G J +6 more
core +1 more source
Novel deletion alleles carrying /chimeric genes in Brazilian patients with 21-hydroxylase deficiency [PDF]
, 2010 Made available in DSpace on 2016-01-24T13:59:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-06-29. Added 1 bitstream(s) on 2016-01-31T13:34:36Z : No.
Araujo, Marcela de +10 more
core +4 more sources
Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients. [PDF]
PLoS ONE, 2014 BackgroundNon-tuberculous mycobacteria (NTM) are ubiquitous in the environment and they infect mainly persons with underlying pulmonary diseases but also previously healthy elderly women.
Hannele Kotilainen +9 more
doaj +1 more source
Lexicographic choice functions [PDF]
, 2017 We investigate a generalisation of the coherent choice functions considered by Seidenfeld et al. (2010), by sticking to the convexity axiom but imposing no Archimedeanity condition. We define our choice functions on vector spaces of options, which allows
de Cooman, Gert +2 more
core +4 more sources
A serine protease isolated from the bristles of the Amazonic caterpillar, Premolis semirufa, is a potent complement system activator. [PDF]
PLoS ONE, 2015 The caterpillar of the moth Premolis semirufa, commonly named pararama, is found in the Brazilian Amazon region. Accidental contact with the caterpillar bristles causes an intense itching sensation, followed by symptoms of an acute inflammation, which ...
Isadora Maria Villas Boas +5 more
doaj +1 more source
Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C. [PDF]
World J Hepatol, 2013 To evaluate serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C virus (HCV) infection.The study included 30 children with chronic HCV infection before receiving antiviral therapy. Chronic HCV infection was defined by positive anti-HCV, a positive polymerase chain reaction for HCV-RNA for more than 6 mo with ...
Behairy BE +4 more
europepmc +3 more sources