Results 61 to 70 of about 389,834 (185)

C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera

Frontiers in Immunology, 2021
Systemic complement activation drives a plethora of pathological conditions, but its role in snake envenoming remains obscure. Here, we explored complement’s contribution to the physiopathogenesis of Naja annulifera envenomation.
Felipe Silva de França, Isadora Maria Villas-Boas, Bruno Cogliati, Trent M. Woodruff, Edimara da Silva Reis, John D. Lambris, Denise V. Tambourgi   +6 more
doaj   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components [PDF]

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Christine Skerka, Skerka, Christine, Schwab, Jasmin, Peter Kraiczy (36173), Jasmin Schwab (105418), Christine Skerka (105424), Zipfel, Peter F., Richter, Dania, Peter Kraiczy, Peter F Zipfel, Dania Richter (105422), Franz-Rainer Matuschka, Peter F. Zipfel, Kraiczy, Peter, Reinhard Wallich (57833), Matuschka, Franz-Rainer, Dania Richter, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Reinhard Wallich, Jasmin Schwab, Claudia Hammerschmidt (105420), Peter F. Zipfel (105431), Franz-Rainer Matuschka (105426)   +24 more
core   +1 more source

Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma

Frontiers in Endocrinology, 2021
BackgroundEarly diagnosis and therapy of papillary thyroid carcinoma (PTC) is essential for reducing recurrence and improving the long-term survival. In this study, we aimed to investigate the proteome profile of plasma and screen unique proteins which ...
Yichao Wang, Yichao Wang, Shengliang Zhou, Shengliang Zhou, Shengliang Zhou, Dun Wang, Dun Wang, Dun Wang, Tao Wei, Tao Wei, Jingqiang Zhu, Jingqiang Zhu, Zhihui Li   +12 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]

, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Teresia Hallström, Peter F. Zipfel, Zipfel, Peter F, Christine Skerka, Hallström, Teresia, Kraiczy, Peter, Skerka, Christine, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Zipfel, Peter F., Reinhard Wallich, Peter Kraiczy, Stevenson, Brian, Brian Stevenson   +14 more
core   +1 more source

Plasmatic Profiling of Individuals With Combinations of Type 2 Diabetes Mellitus, Dyslipidemia and Periodontitis: A Cross‐Sectional Study

Oral Diseases, EarlyView.
ABSTRACT Aim The objective of this study was to investigate the global profile of plasmatic proteins of individuals affected simultaneously or not by type 2 diabetes mellitus (T2DM, well/poorly‐controlled), Dyslipidemia (DL), and Periodontitis (P). Methods Besides periodontal examination, plasma was collected for glycemic, and lipid analyses from 150 ...
François Isnaldo Dias Caldeira, Sâmia Cruz Tfaile Corbi, Alliny de Souza Bastos, Silvana Regina Perez Orrico, Cristiane Ribeiro Salmon, Yizhi Xiao, Walter Luiz Siqueira, Raquel Mantuaneli Scarel‐Caminaga   +7 more
wiley   +1 more source

Low copy numbers of complement C4 and C4A deficiency are risk factors for myositis, its subgroups and autoantibodies

, 2023
Background Idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterised by myositis-related autoantibodies plus infiltration of leucocytes into muscles and/or the skin, leading to the destruction of blood vessels and muscle ...
CY Yu (19169845), RV Curiel (24040599), V Sivaraman (13393503), JA Lamb (24040581), R Abdul-Aziz (24040587), IN Targoff (24040602), YL Wu (14464593), LM Pachman (24040554), E Lundström (23247321), K Driest (24040608), S Rothwell (14617151), KE Miller (24040590), A Payton (13321290), WA Flegel (11140263), G Mamyrova (24040596), EH King (24040584), E Oberle (13590721), S Akoghlanian (24040605), H Chinoy (19671781), O Krystufkova (22443961), William Ollier (23881134), S Coss (16346772), SP Ardoin (24040614), GR Yu (24040593), TP O'Hanlon (24040578), FW Miller (24040542), D Zhou (3556916), A Notarnicola (10187692), L Padyukov (21869102), CH Spencer (4108540), HN Nagaraja (24040611), A Dang (22464697), B De Paepe (24040575), JL De Bleecker (24040572), J Vencovský (19336617), IE Lundberg (10187704), J Drew (13285482), LG Rider (24040545)   +37 more
core  

Maternal protein restriction programs the ageing kidney: Proteomic signatures of early‐life origin renal and metabolic dysfunction

The Journal of Physiology, EarlyView.
Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...
Marina Pereira Pires, Matheus Naia Fioretto, Marcel Rodrigues Ferreira, Isabelle Tenori Ribeiro, Luísa Annibal Barata, Flávia Alessandra Maciel, Lucas Sobrinho Lemos, Renato Mattos, Luiz Marcos Frediane Portela, Patrick Vieira de Souza, Luisa Correia Gomes, Gustavo Monezzi Cordeiro, Wellerson Rodrigo Scarano, Patrícia Aline Boer, Jose Antonio Rocha Gontijo, Luis Antonio Justulin   +15 more
wiley   +1 more source

Mannan-binding lectin and complement C4A in Icelandic multicase families with systemic lupus erythematosus [PDF]

Annals of the Rheumatic Diseases, 2006
To determine whether low mannan-binding lectin (MBL) and C4A null alleles (C4AQ0) are associated with systemic lupus erythematosus (SLE) in multicase families with SLE.Low MBL level was determined by measuring serum levels and by genotyping for mutant structural (B/C/D, designated as 0) and promoter (LX) alleles (by real-time polymerase chain reaction).
S, Saevarsdottir, H, Kristjansdottir, G, Grondal, T, Vikingsdottir, K, Steinsson, H, Valdimarsson   +5 more
openaire   +2 more sources