Results 51 to 60 of about 389,834 (185)

Role of Schizophrenia Risk Factor C4A in Developmental Synaptic Pruning

, 2019
Schizophrenia is a heritable psychiatric disorder of unknown etiology that usually manifests in late adolescence. Recently, elevated expression of the complement component 4A (C4A) allele was found to be a major risk factor for schizophrenia. The C4 gene
Yilmaz, Melis
core   +4 more sources

Changes in Expression of Complement Components in the Ovine Spleen during Early Pregnancy

Animals, 2021
During early gestation in humans, complement regulation is essential for normal fetal growth. It is supposed that a complement pathway participates in maternal splenic immune regulation at the early stage of gestation in ewes.
Ling Yang, Luyu Wang, Jiaxuan Wu, Haichao Wang, Gengxin Yang, Leying Zhang   +5 more
doaj   +1 more source

Sex‐Specific Proteomic Profiling Identifies Pregnancy Zone Protein as a Complement‐Linked Marker of Adverse Prognosis in Esophageal Adenocarcinoma

International Journal of Cancer, EarlyView.
ABSTRACT Esophageal adenocarcinoma (EAC) exhibits marked male predominance with male‐to‐female ratios reaching 8.5:1, yet the molecular basis underlying this sex disparity remains poorly characterized. We analyzed 92 EAC specimens using mass spectrometry–based proteomics, comprising 47 female and 45 male tumors from treatment‐naïve patients ...
Alexander Quaas, Hanna Schiemann, Su Ir Lyu, Thomas Zander, Axel Hillmer, Hans Schlößer, Christiane J. Bruns, Reinhard Büttner, Bastian Grothey   +8 more
wiley   +1 more source

The interaction between circulating complement proteins and cutaneous microvascular endothelial cells in the development of childhood Henoch-Schönlein Purpura. [PDF]

PLoS ONE, 2015
In addition to IgA, the deposition of complement (C)3 in dermal vessels is commonly found in Henoch-Schönlein purpura (HSP). The aim of this study is to elucidate the role of circulating complement proteins in the pathogenesis of childhood HSP.Plasma ...
Yao-Hsu Yang, I-Jung Tsai, Chun-Jung Chang, Ya-Hui Chuang, Hui-Yao Hsu, Bor-Luen Chiang   +5 more
doaj   +1 more source

Subunits of C1Q Are Associated With the Progression of Intermittent Claudication to Chronic Limb-Threatening Ischemia

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe pathophysiological mechanisms of intermittent claudication (IC) progression to chronic limb-threatening ischemia (CLTI) are still vague and which of patients with IC will become CLTI are unknown.
Ziping Yao, Bihui Zhang, Guochen Niu, Ziguang Yan, Xiaoqiang Tong, Yinghua Zou, Min Yang   +6 more
doaj   +1 more source

Enterovirus infections in children

Pediatric Investigation, EarlyView.
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen, Lingyun Guo, Xiaobo Lei, Linqing Zhao, Mingyan Hei, Jun Shen, Ju Yin, Fei Li, Jikui Deng, Gang Liu, Yong Zhang, Zhengde Xie   +11 more
wiley   +1 more source

Novel tetronamides derived from mucobromic acid: synthesis, structural elucidation, DFT calculations and phytotoxic activity

Pest Management Science, EarlyView.
The acyclic mucobromic acid, activated by (1S)‐(+)‐10‐camphorsulfonic acid, afforded the chiral compound 1b, precursor for aza‐Michael addition/elimination on the butenolide yielding tetronamides 2b‐7b. Their relative SRSR configuration was confirmed by the spectrometric methods, DFT calculation and statistical methods.
Kamylla CF Faria, Vitor C Baia, Elson S Alvarenga   +2 more
wiley   +1 more source

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Complement activation and regulation in preeclamptic placenta

Frontiers in Immunology, 2014
Preeclampsia (PE) is a common disorder of pregnancy originating in the placenta. We examined whether excessive activation or poor regulation of the complement system at the maternal-fetal interface could contribute to the development of PE.
A. Inkeri eLokki, A. Inkeri eLokki, A. Inkeri eLokki, Jenni eHeikkinen-Eloranta, Jenni eHeikkinen-Eloranta, Hanna eJarva, Hanna eJarva, Hanna eJarva, Terhi eSaisto, Marja-Liisa eLokki, Hannele eLaivuori, Hannele eLaivuori, Seppo eMeri, Seppo eMeri, Seppo eMeri   +14 more
doaj   +1 more source