Results 71 to 80 of about 11,655 (197)

Detection of both isotypes of complement C4, C4A and C4B, in normal human glomeruli

Kidney International, 1986
Monoclonal antibodies reactive against the complement C4A and C4B isotypic components were used in an immunoperoxidase technique for the histological study of normal human renal tissue. Prominent staining with both antibodies was seen in the mesangial areas of all normal kidney sections investigated.
Feucht, Helmut E., Jung, Christina M., Gokel, Michael J., Riethmüller, Gert, Zwirner, Jörg, Brase, Angelika, Held, Eckhard, O'Neill, Geoffrey J.   +7 more
openaire   +2 more sources

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source

Complement activation and regulation in preeclamptic placenta

Frontiers in Immunology, 2014
Preeclampsia (PE) is a common disorder of pregnancy originating in the placenta. We examined whether excessive activation or poor regulation of the complement system at the maternal-fetal interface could contribute to the development of PE.
A. Inkeri eLokki, A. Inkeri eLokki, A. Inkeri eLokki, Jenni eHeikkinen-Eloranta, Jenni eHeikkinen-Eloranta, Hanna eJarva, Hanna eJarva, Hanna eJarva, Terhi eSaisto, Marja-Liisa eLokki, Hannele eLaivuori, Hannele eLaivuori, Seppo eMeri, Seppo eMeri, Seppo eMeri   +14 more
doaj   +1 more source

Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma

Frontiers in Endocrinology, 2021
BackgroundEarly diagnosis and therapy of papillary thyroid carcinoma (PTC) is essential for reducing recurrence and improving the long-term survival. In this study, we aimed to investigate the proteome profile of plasma and screen unique proteins which ...
Yichao Wang, Yichao Wang, Shengliang Zhou, Shengliang Zhou, Shengliang Zhou, Dun Wang, Dun Wang, Dun Wang, Tao Wei, Tao Wei, Jingqiang Zhu, Jingqiang Zhu, Zhihui Li   +12 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera

Frontiers in Immunology, 2021
Systemic complement activation drives a plethora of pathological conditions, but its role in snake envenoming remains obscure. Here, we explored complement’s contribution to the physiopathogenesis of Naja annulifera envenomation.
Felipe Silva de França, Isadora Maria Villas-Boas, Bruno Cogliati, Trent M. Woodruff, Edimara da Silva Reis, John D. Lambris, Denise V. Tambourgi   +6 more
doaj   +1 more source

Plasmatic Profiling of Individuals With Combinations of Type 2 Diabetes Mellitus, Dyslipidemia and Periodontitis: A Cross‐Sectional Study

Oral Diseases, EarlyView.
ABSTRACT Aim The objective of this study was to investigate the global profile of plasmatic proteins of individuals affected simultaneously or not by type 2 diabetes mellitus (T2DM, well/poorly‐controlled), Dyslipidemia (DL), and Periodontitis (P). Methods Besides periodontal examination, plasma was collected for glycemic, and lipid analyses from 150 ...
François Isnaldo Dias Caldeira, Sâmia Cruz Tfaile Corbi, Alliny de Souza Bastos, Silvana Regina Perez Orrico, Cristiane Ribeiro Salmon, Yizhi Xiao, Walter Luiz Siqueira, Raquel Mantuaneli Scarel‐Caminaga   +7 more
wiley   +1 more source

Heterogeneity in the structural basis of the human complement C4A null allele (C4A*Q0) as revealed by HindIII restriction fragment length polymorphism analysis [PDF]

FEBS Letters, 1987
The highly polymorphic fourth component of human complement (C4) is usually encoded by two genes, C4A and C4B, adjacent to the 21‐hydroxylase (21‐OH) genes, 21‐OHA and 21‐OHB, and is also remarkable in the high frequency of the ‘null’ alleles, C4A*Q0 and C4B*Q0.
Uring-Lambert, Béatrice, Vegnaduzzi, Nathalie, Carroll, Michael C., Tongio, Marie-Marthe, Goetz, Joëlle, Hauptmann, Georges   +5 more
openaire   +2 more sources

Synthesis, Photophysical Characterization, and Anticancer Evaluation of Novel Furochromene Derivatives

ChemistryOpen, Volume 15, Issue 6, June 2026.
This is the first study on novel furochromene derivatives. A series of novel furochromen derivatives, namely (2E)‐1‐(6‐hydroxy‐4,7‐dimethoxy‐1‐benzofuran‐5‐yl)‐3‐arylprop‐2‐en‐1‐ones 4a–c, were synthesized via the Knoevenagel condensation of 6‐hydroxy‐4,7‐dimethoxybenzofuran‐5‐ylethanone 2 with various aromatic aldehydes.
Amal Rabahi, Mustapha Mounir Bouhenna, Hasnia Abdeldjebar, Massinissa Baymout, Malika Makhloufi‐Chebli, Walter Luyten, Hamdi Bendif, Anis Ahmad Chaudhary, Walid Elfalleh, Stefania Garzoli   +9 more
wiley   +1 more source

Proteomic characterization of thiazolidinedione regulation of obese adipose secretome in Zucker obese rats [PDF]

, 2009
Signaling molecules released by adipose tissue have been implicated in inflammation, adipocyte dysfunction and systemic insulin resistance. In this study, we used 2-D LC-MS/MS and quantitative proteomics approaches to characterize the obese adipose ...
Chen, Xiaoli, Cushman, Samuel W., Hess, Sonja, Hunt, Desmond   +3 more
core   +1 more source