Results 71 to 80 of about 389,834 (185)

Acupuncture Attenuates Neuroinflammation Following Acute Cerebral Infarction by Downregulating SPP1 to Ameliorate Immunological Niches

Brain and Behavior, Volume 16, Issue 9, September 2026.
The study workflow and key mechanistic findings are illustrated. In cohort 1, serum samples from acute cerebral infarction (ACI) patients and healthy controls were screened using proteomics to identify differentially expressed proteins. In cohort 2, the therapeutic effects of acupuncture on ACI were further validated.
Jiang‐Peng Cao, Xiao‐Xi Liu, Ling‐Fei Wang, Ying Zhou, Lin Zhang, Xu‐Juan Chen, Yue‐Xin Lin, Lin‐Ling Chen, Yuan‐Hao Du   +8 more
wiley   +1 more source

The Molecular Basis of Complete Complement C4A and C4B Deficiencies in a Systemic Lupus Erythematosus Patient with Homozygous C4A and C4B Mutant Genes [PDF]

The Journal of Immunology, 2002
Abstract The disease course of a complete C4-deficient patient in the U.S. was followed for 18 years. The patient experienced multiple episodes of infection, and he was diagnosed with systemic lupus erythematosus at age 9 years. The disease progressed to WHO class III mild lupus nephritis and to fatal CNS vasculitis at age 23 years ...
Kristi L, Rupert, Joann M, Moulds, Yan, Yang, Frank C, Arnett, Robert W, Warren, John D, Reveille, Barry L, Myones, Carol A, Blanchong, C Yung, Yu   +8 more
openaire   +2 more sources

The Airway Transcriptome in Type 2 Cytokine Biomarker‐High and ‐Low Severe Asthma

Allergy, Volume 81, Issue 9, Page 3300-3317, September 2026.
This study distinguishes severe asthma–related airway transcriptomic changes from the effects of high‐dose ICS. Most dysregulated genes in severe asthma show concordance with corticosteroid responses. Corticosteroid‐resistant T2‐high asthma featured T2‐high and epithelial barrier gene upregulation, while T2‐low asthma featured Th1/IL‐17 signatures. ASM,
Jiashu Shen, Rekha Chaudhuri, Stephen Bicknell, Adel H. Mansur, Rahul Shrimanker, Ian D. Pavord, Stephen J. Fowler, Vanessa Brown, Lorcan P. McGarvey, Peter H. Howarth, Sven‐Erik Dahlén, Ian M. Adcock, Nazanin Zounemat‐Kermani, Joseph R. Arron, Liam G. Heaney, David F. Choy, Timothy S. C. Hinks, Emanuele Marchi, Peter Bradding, on behalf of the UK Medical Research Council Refractory Asthma Stratification programme (RASP‐UK)   +19 more
wiley   +1 more source

From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Twelve N‐acylhydrazone derivatives (5a–f, 6a–f) were synthesized and characterized. Compounds displayed potent submicromolar inhibition against both MAO‐A and MAO‐B. Compound 6e exhibited the strongest activity (IC50 = 0.073 μM for MAO‐A; 0.064 μM for MAO‐B). Kinetic and docking analyses confirmed reversible, competitive inhibition via FAD interaction.
Hasan Erdinç Sellitepe, Ahmet Buğra Aksel, Ezgi Pehlivanlar Yavrucu, Hilal Zıvalı, Begüm Nurpelin Sağlık Özkan, İnci Selin Doğan   +5 more
wiley   +1 more source

COMPLEMENT-MEDIATED ADIPOCYTE LYSIS BY NEPHRITIC FACTOR SERA [PDF]

, 1993
Recent data indicate a previously unsuspected link between the complement system and adipocyte biology. Murine adipocytes produce key components of the alternative pathway of complement and are able to activate this pathway.
Lachmann, PJ, Peters, DK, P J Lachmann, D K Peters, P W Mathieson, Oliveira, DBG, R Würzner, D B Oliveria, Mathieson, PW, Würzner, R, Oliveria, DB   +10 more
core   +1 more source

Serum proteomic analysis uncovers novel serum biomarkers for depression

Frontiers in Psychiatry
ObjectiveThe identification of depression primarily relies on the clinical symptoms and psychiatric evaluation of the patient, in the absence of objective and quantifiable biomarkers within clinical settings.
Aihong Guo, Aihong Guo, Bingju Wang, Bingju Wang, Bingju Wang, Jiangbo Ding, Jiangbo Ding, Lihong Zhao, Xiaofei Wang, Chen Huang, Chen Huang, Bo Guo, Bo Guo   +12 more
doaj   +1 more source

Associação do alótipo raro C4A6 do sistema complemento com a doença cardíaca reumática Association of the C4A6 rare allotype with rheumatic heart disease

Revista Brasileira de Reumatologia, 2004
OBJETIVO: determinar se os alótipos do Fator B (BF), C2 e C4 (C4A e C4B) do sistema complemento poderiam ser marcadores para a doença cardíaca reumática (DCR) na população brasileira. MÉTODOS: foram estudados 49 pacientes com DCR crônica.
Iara Jose de Messias-Reason, Ednéia Cavalcanti, Sebastião Cézar Radominski   +2 more
doaj   +1 more source

Antiglycation of Insulin by Selected Six Bioactive Peanut Sprout Stilbenoids and Demonstration of Methylglyoxal‐Mediated Biphasic Insulin Glycation by O‐Phenylenediamine Derivatization

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Graphical abstract demonstrates 6 peanut sprout containing stilbenoids exhibiting varied structure‐activity potency in protection of insulin integrity from glycation mediated by methylglyoxal (MG), glucose and fructose. Meanwhile, MG‐mediated biphasic insulin glycation was evidenced in Tricine SDS‐PAGE analysis and supported by O‐phenylenediamine (OPD)
Po‐Chang Chiu, Shu‐Mei Lin, Yu‐Jang Li, Chih‐Yu Lo, Robin Y.‐Y. Chiou   +4 more
wiley   +1 more source

Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration. [PDF]

, 2016
Background: The aim of this study was to investigate the plasma levels of complement C3a, C4a, and C5a in different types of neovascular age-related macular degeneration (nAMD) and whether the levels were related to patients’ responsiveness to anti-VEGF ...
Judith Lechner, Lechner, Judith, Xu, Heping, Mei Chen, Chen, Mei, Chakravarthy, Usha, Ruth E. Hogg, Toth, Levente, Levente Toth, Giuliana Silvestri, Heping Xu, Silvestri, Giuliana, Hogg, Ruth; id_orcid, Usha Chakravarthy   +13 more
core   +1 more source

Biofluid Biomarkers of Cognitive Functioning in Bipolar Disorder: A Systematic Review by the Targeting Cognition and Older‐Age Bipolar Disorder ISBD Task Forces

Bipolar Disorders, Volume 28, Issue 5, August 2026.
ABSTRACT Background Cognitive impairment is common in bipolar disorder (BD), but the underlying pathophysiology remains unclear. This systematic review aimed to (1) summarize all literature describing relationships of biofluid biomarkers and cognition in BD and (2) identify which biofluid biomarkers correlate most consistently with cognition in BD ...
Alexandra J. M. Beunders, Sigfried N. T. M. Schouws, Andrew T. Olagunju, Vicent Balanzá‐Martínez, Nicole C. M. Korten, Ralph W. Kupka, Katherine E. Burdick, Andre F. Carvalho, Ariel G. Gildengers, Lars V. Kessing, Roger S. McIntyre, Paula V. Nunes, Ayal Schaffer, Ivan J. Torres, Shang‐Ying Tsai, Tamsyn E. Van Rheenen, Eduard Vieta, Lakshmi N. Yatham, Allan H. Young, Lisa T. Eyler, Kamilla W. Miskowiak, Annemiek Dols   +21 more
wiley   +1 more source