Results 81 to 90 of about 389,834 (185)

Multi‐Omics‐Guided Design and Safety Engineering of Nucleic Acid Therapeutics: From Molecular Perturbation to Predictive Toxicology and Precision Translation

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Multi‐omics (proteomics, metabolomics, and single‐cell/spatial transcriptomics) provides a systems framework to distinguish on‐target efficacy from off‐target and toxicity signatures of chemically modified nucleic acid therapeutics, enabling omics‐guided structure–activity and safety optimisation from discovery to clinical translation. ABSTRACT Nucleic
Gurjit Kaur Bhatti, Anushka Verma, Komal Devi, Naina Khullar, Inderpal Singh Sidhu, Umesh Chand Singh Yadav, Jasvinder Singh Bhatti   +6 more
wiley   +1 more source

Cutaneous IgA Vasculitis in Primary Sjögren Disease: Findings From a Medical Record–Based Review

ACR Open Rheumatology, Volume 8, Issue 7, July 2026.
Objective This study aimed to describe clinical observations of patients presenting with palpable purpura, which is suspected to represent IgA vasculitis (IgAV) based on direct immunofluorescence (DIF), who were ultimately diagnosed with cutaneous vasculitis associated with primary Sjögren disease (SjD).
Shay Brikman, Mohammad Egbaria, Amir Bieber   +2 more
wiley   +1 more source

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Sim, Robert B., Sloan, Jeremy, Green, Malcolm L.H., Sim, Edith, Salvador-Morales, Carolina, Green, Malcolm L. H.   +6 more
core   +1 more source

Engineering novel complement activity into a pulmonary surfactant protein [PDF]

, 2010
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Toth, Julia, Wilhelm J. Schwaeble, Christopher Furze, Russell Wallis, Keeble, A. H., Julia Toth, Keeble, Anthony H., Girija, Umakhanth Venkatraman, Wallis, Russell, Mitchell, D. A., Daniel A. Mitchell, Toth, J., Schwaeble, W. J., Schwaeble, Wilhelm J., Anthony H. Keeble, Furze, C., Umakhanth Venkatraman Girija, Furze, Christopher M., Mitchell, Daniel A., Wallis, R., Venkatraman Girija, U.   +20 more
core   +1 more source

Sample processing time but not storage time affects complement activation markers C4a, C4d, C3a, iC3b, Bb, C5a, and sC5b-9 levels in EDTA-plasma of individuals at clinical high-risk for psychosis

Biomarkers in Neuropsychiatry
The complement system is an important part of the innate immune system and plays a key role in inflammatory processes. Concentrations of complement activation fragments in plasma are markers of systemic activation and have been found to be altered in a ...
Eleftheria Kodosaki, Colm Healy, Jonah F. Byrne, Melanie Föcking, Mary Cannon, Diana O. Perkins, David Cotter, Meike Heurich   +7 more
doaj   +1 more source

Complement anaphylatoxin C4a inhibits C5a-induced neointima formation following arterial injury

Molecular Medicine Reports, 2014
Interactions between complement anaphylatoxins have been investigated in numerous fields; however, their functions during arterial remodeling following injury have not been studied. The inhibitory effect of complement anaphylatoxin C4a on neointima formation induced by C5a following arterial injury was investigated.
ZHAO, YAN, XU, HENG, YU, WENHUI, XIE, BAO-DONG   +3 more
openaire   +3 more sources

Association Study of the Complement Component C4 Gene in Tardive Dyskinesia

Frontiers in Pharmacology, 2019
Tardive dyskinesia (TD) is a movement disorder that may develop in schizophrenia patients being treated long-term with antipsychotic medication. TD interferes with voluntary movements and leads to stigma, and can be associated with treatment non ...
Clement C. Zai, Clement C. Zai, Clement C. Zai, Clement C. Zai, Arun K. Tiwari, Arun K. Tiwari, Gwyneth C. Zai, Gwyneth C. Zai, Gwyneth C. Zai, Natalie Freeman, Jennie G. Pouget, Jennie G. Pouget, James Greco, Maria Tampakeras, Sajid A. Shaikh, Deanna Herbert, Heather Emmerson, Sheraz Y. Cheema, Nicole Braganza, Daniel J. Müller, Daniel J. Müller, Daniel J. Müller, Aristotle N. Voineskos, Aristotle N. Voineskos, Aristotle N. Voineskos, Gary Remington, Gary Remington, Gary Remington, James L. Kennedy, James L. Kennedy, James L. Kennedy   +30 more
doaj   +1 more source

Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice. [PDF]

Nat Neurosci, 2021
Yilmaz M, Yalcin E, Presumey J, Aw E, Ma M, Whelan CW, Stevens B, McCarroll SA, Carroll MC.   +8 more
europepmc   +1 more source

Usefulness and analytical performances of complement multiplex assay for measuring complement biomarkers in plasma

International audienceIntroduction. The complement system is involved in numerous diseases, through diverse mechanisms and degree of activation. With the emergence of complement targeting therapeutic, simple and accessible tools to evaluate the extent of
Courbebaisse, Marie, Duval, Anna, Vieira-Martins, Paula, Chauvet, Sophie, Grunenwald, Anne, Peliconi, Julie, Frémeaux-Bacchi, Véronique, Dragon-Durey, Marie-Agnès, Meuleman, Marie-Sophie, Friedlander, Gérard, Revel, Margot, Rezola Artero, Mikel, Dermani, Mohamed, Roumenina, Lubka, Parfait, Béatrice, Lebeaux, David   +15 more
core   +1 more source

Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes

Nature Communications
Progressive supranuclear palsy (PSP), a rare Parkinsonian disorder, is characterized by problems with movement, balance, and cognition. PSP differs from Alzheimer’s disease (AD) and other diseases, displaying abnormal microtubule-associated protein tau ...
Kurt Farrell, Jack Humphrey, Timothy Chang, Yi Zhao, Yuk Yee Leung, Pavel P. Kuksa, Vishakha Patil, Wan-Ping Lee, Amanda B. Kuzma, Otto Valladares, Laura B. Cantwell, Hui Wang, Ashvin Ravi, Claudia De Sanctis, Natalia Han, Thomas D. Christie, Robina Afzal, Shrishtee Kandoi, Kristen Whitney, Margaret M. Krassner, Hadley Ressler, SoongHo Kim, Diana Dangoor, Megan A. Iida, Alicia Casella, Ruth H. Walker, Melissa J. Nirenberg, Alan E. Renton, Bergan Babrowicz, Giovanni Coppola, Towfique Raj, Günter U. Höglinger, Ulrich Müller, Lawrence I. Golbe, Huw R. Morris, John Hardy, Tamas Revesz, Tom T. Warner, Zane Jaunmuktane, Kin Y. Mok, Rosa Rademakers, Dennis W. Dickson, Owen A. Ross, Li-San Wang, Alison Goate, Gerard Schellenberg, Daniel H. Geschwind, PSP Genetics Study Group, John F. Crary, Adam Naj   +49 more
doaj   +1 more source