Complement Activation in Patients with Focal Segmental Glomerulosclerosis. [PDF]
PLoS ONE, 2015 Recent pre-clinical studies have shown that complement activation contributes to glomerular and tubular injury in experimental FSGS. Although complement proteins are detected in the glomeruli of some patients with FSGS, it is not known whether this is ...
Joshua M Thurman +12 more
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The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]
, 2018 The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J +4 more
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Frontiers in Immunology, 2019 APS is the association of antiphospholipid antibodies (aPL) with thromboses and/or recurrent pregnancy loss (RPL). Among patients with SLE, one-third have aPL and 10–15% have a manifestation of secondary APS.
Stephanie L. Savelli +21 more
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Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation [PDF]
, 2018 Background The longstanding association between the major histocompatibility complex (MHC) locus and schizophrenia (SZ) risk has recently been accounted for, partially, by structural variation at the complement component 4 (C4) gene.
A. Corvin +13 more
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Identification of altered plasma proteins by proteomic study in valvular heart diseases and the potential clinical significance. [PDF]
PLoS ONE, 2013 BackgroundLittle is known about genetic basis and proteomics in valvular heart disease (VHD) including rheumatic (RVD) and degenerative (DVD) valvular disease.
Ge Gao +5 more
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Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]
, 2013 This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M +5 more
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Diagnostics, 2020 Animal models of glaucoma, a neurodegenerative disease affecting the retina, offer the opportunity to study candidate molecular biomarkers throughout the disease.
Andrés Fernández-Vega Cueto +7 more
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Profiling Complement System Components in Primary CNS Vasculitis
Cells, 2021 Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji +6 more
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Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]
, 2010 Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H. +4 more
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Complement and transplant-associated thrombotic microangiopathy: Current and future approaches. [PDF]
HemasphereHemaSphere, Volume 10, Issue 4, April 2026.
Cugno M, Onida F, Lämmle B.
europepmc +2 more sources