Results 31 to 40 of about 389,834 (185)

Opposite Profiles of Complement in Antiphospholipid Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Among Patients With Antiphospholipid Antibodies (aPL)

Frontiers in Immunology, 2019
APS is the association of antiphospholipid antibodies (aPL) with thromboses and/or recurrent pregnancy loss (RPL). Among patients with SLE, one-third have aPL and 10–15% have a manifestation of secondary APS.
Stephanie L. Savelli, Stephanie L. Savelli, Stephanie L. Savelli, Robert A. S. Roubey, Kathryn J. Kitzmiller, Kathryn J. Kitzmiller, Danlei Zhou, Danlei Zhou, Danlei Zhou, Haikady N. Nagaraja, Evan Mulvihill, Evan Mulvihill, Fatima Barbar-Smiley, Fatima Barbar-Smiley, Stacy P. Ardoin, Stacy P. Ardoin, Yee Ling Wu, Yee Ling Wu, Yee Ling Wu, Chack-Yung Yu, Chack-Yung Yu, Chack-Yung Yu   +21 more
doaj   +1 more source

Identification of altered plasma proteins by proteomic study in valvular heart diseases and the potential clinical significance. [PDF]

PLoS ONE, 2013
BackgroundLittle is known about genetic basis and proteomics in valvular heart disease (VHD) including rheumatic (RVD) and degenerative (DVD) valvular disease.
Ge Gao, Chao Xuan, Qin Yang, Xiao-Cheng Liu, Zhi-Gang Liu, Guo-Wei He   +5 more
doaj   +1 more source

Systemic Alterations of Immune Response-Related Proteins during Glaucoma Development in the Murine Model DBA/2J

Diagnostics, 2020
Animal models of glaucoma, a neurodegenerative disease affecting the retina, offer the opportunity to study candidate molecular biomarkers throughout the disease.
Andrés Fernández-Vega Cueto, Lydia Álvarez, Montserrat García, Enol Artime, Ana Álvarez Barrios, Ignacio Rodríguez-Uña, Miguel Coca-Prados, Héctor González-Iglesias   +7 more
doaj   +1 more source

Profiling Complement System Components in Primary CNS Vasculitis

Cells, 2021
Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji, Christian W. Keller, Simon Koch, Heinz Wiendl, Christian Gerloff, Tim Magnus, Jan D. Lünemann   +6 more
doaj   +1 more source

The Role of Complement in Cancer Immunotherapy [PDF]

, 2022
The dual role of complement in both cancer development and treatment has been investigated extensively and is characterized by a substantial literature that documents the conditions in which complement can either enhance tumor growth or promote the ...

core   +1 more source

Age-Related Maculopathy Susceptibility 2 and Complement Factor H Polymorphism and Intraocular Complement Activation in Neovascular Age-Related Macular Degeneration

Ophthalmology Science, 2022
Purpose: To investigate the association of risk alleles in complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) with complement activation products in the aqueous humor in eyes with neovascular age-related macular degeneration ...
Yutaka Kato, MD, Yasuharu Oguchi, MD, PhD, Tomoko Omori, PhD, Akihito Kasai, MD, Masashi Ogasawara, MD, Yukinori Sugano, MD, PhD, Kanako Itagaki, MD, Akira Ojima, MD, PhD, Yumi Ishida, Takeshi Machida, PhD, Hideharu Sekine, MD, PhD, Tetsuju Sekiryu, MD, PhD   +11 more
doaj   +1 more source

Restriction fragment analysis of duplication of the fourth component of complement (C4A)

Genomics, 1988
The two genes encoding the fourth component of complement (C4A and C4B) reside between HLA-B and HLA-DR on human chromosome 6. Two kilobases downstream from each C4 gene lies a 21-hydroxylase gene (CA21HA and CA21HB, respectively). Utilizing the method of Southern blotting and a 5'-end 2.4-kb BamHI/KpnI fragment of the C4 cDNA, we have analyzed TaqI ...
R H, McLean, P A, Donohoue, N, Jospe, W B, Bias, C, Van Dop, C J, Migeon   +5 more
openaire   +2 more sources

Impact of C4, C4A and C4B gene copy number variation in the susceptibility, phenotype and progression of systemic lupus erythematosus

Advances in Rheumatology, 2019
Background Complement component 4 (C4) gene copy number (GCN) affects the susceptibility to systemic lupus erythematosus (SLE) in different populations, however the possible phenotype significance remains to be determined.
Kaline Medeiros Costa Pereira, Sandro Perazzio, Atila Granado A. Faria, Eloisa Sa Moreira, Viviane C. Santos, Marcelle Grecco, Neusa Pereira da Silva, Luis Eduardo Coelho Andrade   +7 more
doaj   +1 more source

Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases

Frontiers in Immunology, 2016
The complement system consists of effector proteins, regulators, and receptors that participate in host defense against pathogens. Activation of the complement system, via the classical pathway (CP), has long been recognized in immune complex-mediated ...
Katherine eLintner, Yee Ling eWu, Yan eYang, Charles eSpencer, Georges eHauptmann, Lee eHebert, John eAtkinson, Chack-Yung eYu   +7 more
doaj   +1 more source

Complement-mediated adherence of immune complexes to human erythrocytes Difference in the requirements for C4A and C4B [PDF]

, 1987
The classical pathway of complement is required for the adherence of soluble tetanus toxoid (TT)-human anti-TT complexes to erythrocytes. Using human C4-deficient serum we compared the capacity of the two forms of human C4 (C4A and C4B) to mediate this ...
Jean-Pierre Paccaud, Paccaud, Jean-Pierre, Jurg A. Schifferli, Hauptmann, Georges, Schifferli, Jurg A., Georges Hauptmann   +5 more
core   +1 more source