Results 21 to 30 of about 11,655 (197)

C4a: the third anaphylatoxin of the human complement system. [PDF]

Proceedings of the National Academy of Sciences, 1979
The activation peptide C4a was isolated from C1s-cleaved C4, the fourth component of complement. The peptide appeared to be homogeneous by electrophoresis on cellulose acetate and by polyacrylamide gel electrophoresis. C4a has a molecular weight of 8650 and an electrophoretic mobility at pH 8.6 of +2.1 x 10(-5) cm2V-1 sec-1. Carboxypeptidase B released
J P, Gorski, T E, Hugli, H J, Müller-Eberhard   +2 more
openaire   +2 more sources

Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth

Genome Biology, 2023
Background Increased expression of the complement component 4A (C4A) gene is associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in synaptic pruning; yet, it remains unclear the extent to which upregulation of C4A ...
Leanna M. Hernandez, Minsoo Kim, Pan Zhang, Richard A. I. Bethlehem, Gil Hoftman, Robert Loughnan, Diana Smith, Susan Y. Bookheimer, Chun Chieh Fan, Carrie E. Bearden, Wesley K. Thompson, Michael J. Gandal   +11 more
doaj   +1 more source

Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia

Nature Communications, 2022
Schizophrenia risk has been associated with the complement component 4 (C4) genes. Here the authors show that C4A is elevated in individuals with schizophrenia.
Jessica Gracias, Funda Orhan, Elin Hörbeck, Jessica Holmén-Larsson, Neda Khanlarkani, Susmita Malwade, Sravan K. Goparaju, Lilly Schwieler, İlknur Ş. Demirel, Ting Fu, Helena Fatourus-Bergman, Aurimantas Pelanis, Carleton P. Goold, Anneli Goulding, Kristina Annerbrink, Anniella Isgren, Timea Sparding, Martin Schalling, Viviana A. Carcamo Yañez, Jens C. Göpfert, Johanna Nilsson, Ann Brinkmalm, Kaj Blennow, Henrik Zetterberg, Göran Engberg, Fredrik Piehl, Steven D. Sheridan, Roy H. Perlis, Simon Cervenka, Sophie Erhardt, Mikael Landen, Carl M. Sellgren   +31 more
doaj   +1 more source

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

npj Genomic Medicine, 2022
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk.
Martin Kerick, Marialbert Acosta-Herrera, Carmen Pilar Simeón-Aznar, José Luis Callejas, Shervin Assassi, International SSc Group, Susanna M. Proudman, Mandana Nikpour, Australian Scleroderma Interest Group (ASIG), PRECISESADS Clinical Consortium, Nicolas Hunzelmann, Gianluca Moroncini, Jeska K. de Vries-Bouwstra, Gisela Orozco, Anne Barton, Ariane L. Herrick, Chikashi Terao, Yannick Allanore, Carmen Fonseca, Marta Eugenia Alarcón-Riquelme, Timothy R. D. J. Radstake, Lorenzo Beretta, Christopher P. Denton, Maureen D. Mayes, Javier Martin   +24 more
doaj   +1 more source

Tear-derived exosomal biomarkers of Graves’ ophthalmopathy

Frontiers in Immunology, 2022
Graves’ ophthalmopathy (GO), the most frequent extrathyroidal manifestation of Graves’ disease (GD), can lead to a significant decline in the quality of life in patients.
Ting-Ting Shi, Ru-Xuan Zhao, Zhong Xin, Zhi-Jia Hou, Hua Wang, Rong-Rong Xie, Dong-Mei Li, Jin-Kui Yang   +7 more
doaj   +1 more source

Complement Split Products C3a and C4a in Chronic Lyme Disease [PDF]

Scandinavian Journal of Immunology, 2008
AbstractComplement split products C3a and C4a are reportedly elevated in patients with acute Lyme disease. We have now examined these immunologic markers in patients with chronic Lyme disease compared to appropriate disease controls. The study population consisted of 29 healthy controls, 445 patients with chronic Lyme disease, 11 patients with systemic
R B, Stricker, V R, Savely, N C, Motanya, P C, Giclas   +3 more
openaire   +2 more sources

Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus [PDF]

, 1993
We investigated the Nco I restriction fragment length polymorphism (RFLP) of the tumor necrosis factor beta (TNFB) gene in 173 patients with systemic lupus erythematosus (SLE), 192 unrelated healthy controls, and eleven panel families, all of German ...
Albert, E. D., Bettinotti, M. P., Deicher, H., Hartung, K., Keller, E., Messer, Gerald, Weiss, Elisabeth H.   +6 more
core   +1 more source

The isolation and characterization of bovine C4a, an activation fragment of the fourth component of complement [PDF]

Biochemical Journal, 1979
The fourth component of bovine complement, C4, was cleaved specifically by subcomponent C1s to produce two fragments, C4a and C4b. The smaller, C4a, was isolated in pure form and is a peptide of 9500 mol.wt. containing approx. 84 amino acids and no detectable carbohydrate. C4a has an amino acid composition that is comparable with the anaphylatoxins C3a
N A, Booth, R D, Campbell, M A, Smith, J E, Fothergill   +3 more
openaire   +2 more sources

Complement C4, Infections, and Autoimmune Diseases

Frontiers in Immunology, 2021
Complement C4, a key molecule in the complement system that is one of chief constituents of innate immunity for immediate recognition and elimination of invading microbes, plays an essential role for the functions of both classical (CP) and lectin (LP ...
Hongbin Wang, Hongbin Wang, Hongbin Wang, Mengyao Liu   +3 more
doaj   +1 more source

Multi-lectin Affinity Chromatography and Quantitative Proteomic Analysis Reveal Differential Glycoform Levels between Prostate Cancer and Benign Prostatic Hyperplasia Sera. [PDF]

, 2018
Currently prostate-specific antigen is used for prostate cancer (PCa) screening, however it lacks the necessary specificity for differentiating PCa from other diseases of the prostate such as benign prostatic hyperplasia (BPH), presenting a clinical need
Adusumilli, Ravali, Brooks, James D, Kullolli, Majlinda, Mallick, Parag, Pitteri, Sharon J, Tanimoto, Cheylene, Totten, Sarah M   +6 more
core   +2 more sources