Results 21 to 30 of about 389,834 (185)
C4a: the third anaphylatoxin of the human complement system. [PDF]
Proceedings of the National Academy of Sciences, 1979 The activation peptide C4a was isolated from C1s-cleaved C4, the fourth component of complement. The peptide appeared to be homogeneous by electrophoresis on cellulose acetate and by polyacrylamide gel electrophoresis. C4a has a molecular weight of 8650 and an electrophoretic mobility at pH 8.6 of +2.1 x 10(-5) cm2V-1 sec-1. Carboxypeptidase B released
J P, Gorski +2 more
openaire +2 more sources
Nature Communications, 2022 Schizophrenia risk has been associated with the complement component 4 (C4) genes. Here the authors show that C4A is elevated in individuals with schizophrenia.
Jessica Gracias +31 more
doaj +1 more source
npj Genomic Medicine, 2022 Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk.
Martin Kerick +24 more
doaj +1 more source
Tear-derived exosomal biomarkers of Graves’ ophthalmopathy
Frontiers in Immunology, 2022 Graves’ ophthalmopathy (GO), the most frequent extrathyroidal manifestation of Graves’ disease (GD), can lead to a significant decline in the quality of life in patients.
Ting-Ting Shi +7 more
doaj +1 more source
Complement Split Products C3a and C4a in Chronic Lyme Disease [PDF]
Scandinavian Journal of Immunology, 2008 AbstractComplement split products C3a and C4a are reportedly elevated in patients with acute Lyme disease. We have now examined these immunologic markers in patients with chronic Lyme disease compared to appropriate disease controls. The study population consisted of 29 healthy controls, 445 patients with chronic Lyme disease, 11 patients with systemic
R B, Stricker +3 more
openaire +2 more sources
Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]
, 2012 Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel +17 more
core +1 more source
Complement activation by heparin-protamine complexes during cardiopulmonary bypass: Effect of C4A null allele [PDF]
, 1997 Objectives: The first objective was to determine the effect of inherited differences in the classic pathway complement protein C4 on complement activation by heparin-protamine complexes in cardiac surgery. Specifically, we hypothesized that patients with
Raza, Syed +4 more
core +1 more source
Complement C4, Infections, and Autoimmune Diseases
Frontiers in Immunology, 2021 Complement C4, a key molecule in the complement system that is one of chief constituents of innate immunity for immediate recognition and elimination of invading microbes, plays an essential role for the functions of both classical (CP) and lectin (LP ...
Hongbin Wang +3 more
doaj +1 more source
The isolation and characterization of bovine C4a, an activation fragment of the fourth component of complement [PDF]
Biochemical Journal, 1979 The fourth component of bovine complement, C4, was cleaved specifically by subcomponent C1s to produce two fragments, C4a and C4b. The smaller, C4a, was isolated in pure form and is a peptide of 9500 mol.wt. containing approx. 84 amino acids and no detectable carbohydrate. C4a has an amino acid composition that is comparable with the anaphylatoxins C3a
N A, Booth +3 more
openaire +2 more sources
Complement Activation in Patients with Focal Segmental Glomerulosclerosis. [PDF]
PLoS ONE, 2015 Recent pre-clinical studies have shown that complement activation contributes to glomerular and tubular injury in experimental FSGS. Although complement proteins are detected in the glomeruli of some patients with FSGS, it is not known whether this is ...
Joshua M Thurman +12 more
doaj +1 more source