Results 1 to 10 of about 14,451 (187)

Purified complement C3b triggers phagocytosis and activation of human neutrophils via complement receptor 1 [PDF]

Scientific Reports, 2023
The complement system provides vital immune protection against infectious agents by labeling them with complement fragments that enhance phagocytosis by immune cells.
Elena Boero, Ronald D. Gorham, Emmet A. Francis, Jonathan Brand, Lay Heng Teng, Dennis J. Doorduijn, Maartje Ruyken, Remy M. Muts, Christian Lehmann, Admar Verschoor, Kok P. M. van Kessel, Volkmar Heinrich, Suzan H. M. Rooijakkers   +12 more
doaj   +6 more sources

Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood [PDF]

Frontiers in Immunology, 2022
IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis ...
Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Per H. Nilsson, Ole-Lars Brekke, Ole-Lars Brekke   +14 more
doaj   +2 more sources

Structure of complement fragment C3b–factor H and implications for host protection by complement regulators [PDF]

Nature Immunology, 2009
Factor H (FH) is an abundant regulator of complement activation and protects host cells from self-attack by complement. Here we provide insight into the regulatory activity of FH by solving the crystal structure of the first four domains of FH in complex with its target, complement fragment C3b.
Daniel Ricklin, Piet Gros, Bert Janssen   +2 more
exaly   +4 more sources

Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN) [PDF]

Acta Crystallographica Section F: Structural Biology Communications, 2009
Staphylococcus aureus secretes a number of small proteins that effectively attenuate the human innate immune response. Among these, the staphylococcal complement-inhibitor protein (SCIN) disrupts the function of the complement component 3 (C3) convertase that is initiated through either the classical or the alternative pathway and thereby prevents ...
Daniel Ricklin, Brandon Garcia, John Lambris   +2 more
exaly   +3 more sources

Ionic tethering contributes to the conformational stability and function of complement C3b

Molecular Immunology, 2017
C3b, the central component of the alternative pathway (AP) of the complement system, coexists as a mixture of conformations in solution. These conformational changes can affect interactions with other proteins and complement regulators. Here we combine a computational model for electrostatic interactions within C3b with molecular imaging to study the ...
OSCAR Llorca, Santiago Rodríguez de Cordoba, Andres López-Perrote   +2 more
exaly   +4 more sources

Complement profiling for treatment outcomes in pulmonary TB [PDF]

Frontiers in Immunology
IntroductionThe complement system plays a vital role in the immune response against tuberculosis (TB), aiding in the recognition and clearance of Mycobacterium tuberculosis.
Nathella Pavan Kumar, Nathella Pavan Kumar, Arul Nancy P., Arul Nancy P., Syed Hissar, Shanmugam Sivakumar, Vijay Viswanathan, Ramalingam Bethunaickan, Ramalingam Bethunaickan, Hardy Kornfeld, Subash Babu, Subash Babu   +11 more
doaj   +2 more sources

Inhibition of Complement Will Substantially Reduce the Anemia of Malaria [PDF]

Journal of Immunology Research
There is compelling evidence that complement plays a major role in the elimination of nonparasitized erythrocytes (np-Es) in the anemia of malaria. In fact, for every erythrocyte destroyed after infection by Plasmodium falciparum (Pf) or Plasmodium vivax,
Ronald P. Taylor, Margaret A. Lindorfer
doaj   +2 more sources

Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. [PDF]

PLoS ONE, 2016
Complement factor H-related protein 1 (CFHR1) is a complement regulator which has been reported to regulate complement by blocking C5 convertase activity and interfering with C5b surface association. CFHR1 also competes with complement factor H (CFH) for
Jonathan P Hannan, Jennifer Laskowski, Joshua M Thurman, Gregory S Hageman, V Michael Holers   +4 more
doaj   +1 more source

Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity

Frontiers in Immunology, 2022
The complement system is a part of the innate immune system, where it labels intruding pathogens as well as dying host cells for clearance. If complement regulation is compromised, the system may contribute to pathogenesis.
Henrik Pedersen, Rasmus Kjeldsen Jensen, Annette Gudmann Hansen, Steen Vang Petersen, Steffen Thiel, Nick Stub Laursen, Nick Stub Laursen, Gregers Rom Andersen   +7 more
doaj   +1 more source

Discovery of APL-1030, a Novel, High-Affinity Nanofitin Inhibitor of C3-Mediated Complement Activation

Biomolecules, 2022
Uncontrolled complement activation contributes to multiple immune pathologies. Although synthetic compstatin derivatives targeting C3 and C3b are robust inhibitors of complement activation, their physicochemical and molecular properties may limit access ...
Joshua Garlich, Mathieu Cinier, Anne Chevrel, Anaëlle Perrocheau, David J. Eyerman, Mark Orme, Olivier Kitten, Lukas Scheibler   +7 more
doaj   +1 more source