Results 41 to 50 of about 14,451 (187)

Toxoplasma gondii Recruits Factor H and C4b-Binding Protein to Mediate Resistance to Serum Killing and Promote Parasite Persistence in vivo

Frontiers in Immunology, 2020
Regulating complement is an important step in the establishment of infection by microbial pathogens. Toxoplasma gondii actively resists complement-mediated killing in non-immune human serum (NHS) by inactivating C3b, however the precise molecular basis ...
Patricia M. Sikorski, Patricia M. Sikorski, Alessandra G. Commodaro, Michael E. Grigg   +3 more
doaj   +1 more source

Interaction of uromodulin and complement factor H enhances C3b inactivation [PDF]

Journal of Cellular and Molecular Medicine, 2016
AbstractRecent studies suggest that uromodulin plays an important role in chronic kidney diseases. It can interact with several complement components, various cytokines and immune system cells. Complement factor H (CFH), as a regulator of the complement alternative pathway, is also associated with various renal diseases.
Liu, Maojing, Wang, Yaqin, Wang, Fengmei, Xia, Min, Liu, Ying, Chen, Yuqing, Zhao, Ming‐Hui   +6 more
openaire   +2 more sources

Molecular mechanism of complement inhibition by the trypanosome receptor ISG65

eLife
African trypanosomes replicate within infected mammals where they are exposed to the complement system. This system centres around complement C3, which is present in a soluble form in serum but becomes covalently deposited onto the surfaces of pathogens ...
Alexander D Cook, Mark Carrington, Matthew K Higgins   +2 more
doaj   +1 more source

Effects of Streptococcus pneumoniae strain background on complement resistance. [PDF]

PLoS ONE, 2011
Immunity to infections caused by Streptococcus pneumoniae is dependent on complement. There are wide variations in sensitivity to complement between S. pneumoniae strains that could affect their ability to cause invasive infections.
Catherine Hyams, Sophia Opel, William Hanage, Jose Yuste, Katie Bax, Birgitta Henriques-Normark, Brian G Spratt, Jeremy S Brown   +7 more
doaj   +1 more source

Exploring the involvement of the alternative complement pathway in non-infectious uveitis pathogenesis

Frontiers in Immunology, 2023
PurposeNon-infectious uveitis is a complex disease characterized by intraocular inflammation of the uveal area and the leading cause of vision impairment and blindness in young people globally.
Prerna Kulshrestha, Prerna Kulshrestha, Pallavi Goel, Somasheila Murthy, Mudit Tyagi, Soumvaya Basu, Pratik Gogri, Inderjeet Kaur   +7 more
doaj   +1 more source

THE INTERACTION OF ARENICIN-1 WITH C3B COMPLEMENT PROTEIN

Medical academic journal, 2019
The complement system and antimicrobial peptides (AMPs) are known to be vital humoral factors of innate immunity. Earlier we showed the double-sided influence of arenicin-1 (Ar-1), the AMP from a sea polychaeta Arenicola marina, on the complement activation.
E S Umnyakova, I A Krenev, S V Legkovoy, A V Sokolov, O N Rogacheva, T V Ovchinnikova, V N Kokryakov, M N Berlov   +7 more
openaire   +2 more sources

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Defining Targets for Complement Components C4b and C3b on the Pathogenic Neisseriae [PDF]

Infection and Immunity, 2008
ABSTRACTComplement is a key arm of the innate immune defenses against the pathogenic neisseriae. We previously identified lipooligosaccharide onNeisseria meningitidisas an acceptor for complement C4b. Little is known about other neisserial targets for complement proteins C3 and C4, which covalently attach to bacterial surfaces and initiate opsonization
Lewis, Lisa A., Ram, Sanjay, Prasad, Alpana, Gulati, Sunita, Getzlaff, Silke, Blom, Anna M., Vogel, Ulrich, Rice, Peter A   +7 more
openaire   +3 more sources

Pegcetacoplan Delivers Real‐World Therapeutic Benefits and Reduces Disease Burden for Patients With Paroxysmal Nocturnal Haemoglobinuria: A Systematic Literature Review of Pegcetacoplan Real‐World Clinical and Patient‐Reported Outcomes

European Journal of Haematology, EarlyView.
ABSTRACT Aims Paroxysmal nocturnal haemoglobinuria (PNH) is an ultra‐rare, acquired, non‐malignant haematological disorder that, if left untreated, can lead to significant morbidity. This systematic literature review (SLR) summarized real‐world evidence (RWE) for pegcetacoplan, a complement 3/3b inhibitor (C3i) available since 2021.
Juan Carlos Vallejo Llamas, Koo Wilson, Zalmai Hakimi, Vikte Lionikaite, Elisabetta Metafuni   +4 more
wiley   +1 more source

Divergent roles of ent‐kaurene oxidase paralogs in rice momilactone biosynthesis

Journal of Integrative Plant Biology, EarlyView.
Rice contains a five‐gene tandem array of genes encoding members of the ent‐kaurene oxidase (KO) family, with OsKOL4 and OsKOL5 playing divergent roles in momilactone metabolism, but both acting in the production of antifungal and antibacterial phytoalexins, which are important for disease resistance.
Zhibiao Wang, Yiling Feng, Leiming You, Meimei Xu, Kristin Helwig, Riqing Li, Si Nian Char, Bing Yang, Reuben J. Peters   +8 more
wiley   +1 more source