Results 41 to 50 of about 27,085 (217)

Role of Electrostatic Hotspots in the Selectivity of Complement Control Proteins Toward Human and Bovine Complement Inhibition

Frontiers in Molecular Biosciences, 2021
Poxviruses are dangerous pathogens, which can cause fatal infection in unvaccinated individuals. The causative agent of smallpox in humans, variola virus, is closely related to the bovine vaccinia virus, yet the molecular basis of their selectivity is ...
Yogesh B. Narkhede, Avneesh K. Gautam, Rohaine V. Hsu, Wilson Rodriguez, Nehemiah T. Zewde, Reed E. S. Harrison, Pablo R. Arantes, Zied Gaieb, Ronald D. Gorham, Chris Kieslich, Chris Kieslich, Dimitrios Morikis, Arvind Sahu, Giulia Palermo, Giulia Palermo   +14 more
doaj   +1 more source

Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune system [PDF]

, 2020
Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Magez, Stefan, Obishakin, Emmanuel Tumininu, Pinto Torres, Joar Esteban, Radwanska, Magdalena   +3 more
core   +1 more source

Complement C3b receptors on erythrocytes in patients with juvenile rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 1987
AbstractForty patients with juvenile rheumatoid arthritis (JRA) were examined for C3b receptor (CR1) levels on erythrocytes (by an enzyme‐linked immunosorbent assay), levels of circulating immune complexes (IC) (by a polyethylene glycol precipitation–complement consumption method), C3d split products (by intermediate gel rocket immunoelectrophoresis ...
Thomsen, Bjarne S., Heilmann, Carsten, Jacobsen, Svend E. H., Pedersen, Freddy Karup, Morling, Niels, Jakobsen, Bodil K., Svejgaard, Arne, Nielsen, Henrik   +7 more
openaire   +3 more sources

Microbes Bind Complement Inhibitor Factor H via a Common Site [PDF]

, 2013
To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma
A Bhattacharjee, A Kunert, A. Bhattacharjee, A. Goldman, AO Edwards, AP Herbert, BJ Janssen, C Blanc, DL Gordon, Frank R. DeLeo, G Madico, H Amdahl, H. Amdahl, HK Kim, HP Morgan, J Hellwage, J Wu, J. V. McDowell, JC Leo, JD Lambris, JL Haines, JM Weiler, K Haapasalo, K Whaley, KM Hovis, KM Hovis, KM Hovis, M. J. Lehtinen, MC Schneider, MJ Lehtinen, MK Pangburn, MK Pangburn, P Kraiczy, PF Zipfel, PF Zipfel, R. Marconi, S Hammerschmidt, S Kühn, S Meri, S. Hyvärinen, S. Meri, T Hallström, T Kajander, T Meri, T. Meri, T. S. Jokiranta, TK Blackmore, TK Blackmore, TS Jokiranta, TS Jokiranta, TS Jokiranta, U Sjobring, V Koistinen, VP Ferreira, VP Ferreira   +54 more
core   +9 more sources

Synovial Complement Factors in Patients with Periprosthetic Joint Infection after Undergoing Revision Arthroplasty of the Hip or Knee Joint

Diagnostics, 2021
The role and diagnostic value of the synovial complement system in patients with low-grade periprosthetic joint infection (PJI) are unclear. We sought to evaluate, for the first time, the usefulness of synovial complement factors in these patients by ...
Frank Sebastian Fröschen, Sophia Schell, Matthias Dominik Wimmer, Gunnar Thorben Rembert Hischebeth, Hendrik Kohlhof, Sascha Gravius, Thomas Martin Randau   +6 more
doaj   +1 more source

The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]

, 2018
The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J, Graves, Edward E, Kim, Ryan K, Melemenidis, Stavros, Olcina, Monica M   +4 more
core   +1 more source

The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct Binding to the Proconvertase C3b-B

Frontiers in Immunology, 2017
Saliva of the blood feeding sand fly Lutzomyia longipalpis was previously shown to inhibit the alternative pathway (AP) of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP.
Antonio F. Mendes-Sousa, Antonio F. Mendes-Sousa, Vladimir Fazito do Vale, Vladimir Fazito do Vale, Naylene C. S. Silva, Anderson B. Guimaraes-Costa, Marcos H. Pereira, Marcos H. Pereira, Mauricio R. V. Sant’Anna, Mauricio R. V. Sant’Anna, Fabiano Oliveira, Shaden Kamhawi, José M. C. Ribeiro, John F. Andersen, Jesus G. Valenzuela, Ricardo N. Araujo, Ricardo N. Araujo   +16 more
doaj   +1 more source

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]

, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Hallström, Teresia, Hammerschmidt, Claudia, Kraiczy, Peter, Skerka, Christine, Stevenson, Brian, Wallich, Reinhard, Zipfel, Peter F.   +6 more
core   +4 more sources

A novel and rapid method to purify the human complement opsonin C3b from human plasma

Frontiers in Immunology
Complement opsonin C3b is at the center of the complement cascade. All complement initiation pathways converge when convertases activate C3, converting it into the anaphylatoxin C3a and the opsonin C3b, which can attach to surfaces via its freshly ...
Jannik Sichau, Christoph Q. Schmidt
doaj   +1 more source

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

Frontiers in Immunology, 2019
Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the ...
Ramon M. van den Bos, Nicholas M. Pearce, Joke Granneman, T. Harma C. Brondijk, Piet Gros   +4 more
doaj   +1 more source