Results 61 to 70 of about 27,085 (217)

Effects of Streptococcus pneumoniae strain background on complement resistance. [PDF]

PLoS ONE, 2011
Immunity to infections caused by Streptococcus pneumoniae is dependent on complement. There are wide variations in sensitivity to complement between S. pneumoniae strains that could affect their ability to cause invasive infections.
Catherine Hyams, Sophia Opel, William Hanage, Jose Yuste, Katie Bax, Birgitta Henriques-Normark, Brian G Spratt, Jeremy S Brown   +7 more
doaj   +1 more source

Exploring the involvement of the alternative complement pathway in non-infectious uveitis pathogenesis

Frontiers in Immunology, 2023
PurposeNon-infectious uveitis is a complex disease characterized by intraocular inflammation of the uveal area and the leading cause of vision impairment and blindness in young people globally.
Prerna Kulshrestha, Prerna Kulshrestha, Pallavi Goel, Somasheila Murthy, Mudit Tyagi, Soumvaya Basu, Pratik Gogri, Inderjeet Kaur   +7 more
doaj   +1 more source

THE INTERACTION OF ARENICIN-1 WITH C3B COMPLEMENT PROTEIN

Medical academic journal, 2019
The complement system and antimicrobial peptides (AMPs) are known to be vital humoral factors of innate immunity. Earlier we showed the double-sided influence of arenicin-1 (Ar-1), the AMP from a sea polychaeta Arenicola marina, on the complement activation.
E S Umnyakova, I A Krenev, S V Legkovoy, A V Sokolov, O N Rogacheva, T V Ovchinnikova, V N Kokryakov, M N Berlov   +7 more
openaire   +2 more sources

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Defining Targets for Complement Components C4b and C3b on the Pathogenic Neisseriae [PDF]

Infection and Immunity, 2008
ABSTRACTComplement is a key arm of the innate immune defenses against the pathogenic neisseriae. We previously identified lipooligosaccharide onNeisseria meningitidisas an acceptor for complement C4b. Little is known about other neisserial targets for complement proteins C3 and C4, which covalently attach to bacterial surfaces and initiate opsonization
Lewis, Lisa A., Ram, Sanjay, Prasad, Alpana, Gulati, Sunita, Getzlaff, Silke, Blom, Anna M., Vogel, Ulrich, Rice, Peter A   +7 more
openaire   +3 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Functional Analysis of Variants in Complement Factor I Identified in Age-Related Macular Degeneration and Atypical Hemolytic Uremic Syndrome

Frontiers in Immunology, 2022
Complement factor I (FI) is a central inhibitor of the complement system, and impaired FI function increases complement activation, contributing to diseases such as age-related macular degeneration (AMD) and atypical hemolytic uremic syndrome (aHUS ...
Sarah de Jong, Anita de Breuk, Bjorn Bakker, Suresh Katti, Carel B. Hoyng, Sara C. Nilsson, Anna M. Blom, Lambert P. van den Heuvel, Lambert P. van den Heuvel, Lambert P. van den Heuvel, Anneke I. den Hollander, Anneke I. den Hollander, Elena B. Volokhina, Elena B. Volokhina, Elena B. Volokhina   +14 more
doaj   +1 more source

Retraction Note: The structure of complement C3b provides insights into complement activation and regulation [PDF]

Nature, 2016
This Letter is retracted by Nature. This follows an investigation by the University of Alabama at Birmingham, Alabama, USA, of structures deposited into the Protein Data Bank under accession 2HR0 by H. M. Krishna Murthy. Co-authors who agree with the Retraction.
A. Abdul Ajees, K. Gunasekaran, John E. Volanakis, Sthanam. V. L. Narayana, Girish J. Kotwal, H. M. Krishna Murthy   +5 more
openaire   +1 more source

Analysis of the Recovery of Immune Status in the Patients With Paroxysmal Nocturnal Hemoglobinuria After Treatment With C5 Complement Inhibitor

Journal of Clinical Laboratory Analysis, EarlyView.
We retrospectively evaluated the impact of C5 complement inhibition on immune cell profiles and recovery in 27 PNH patients; both CD4+ and CD8+ T cells exhibited partial recovery, while B cell counts increased but remained below normal levels. In contrast, Treg cells were significantly reduced in PNH patients and showed no notable change post‐treatment.
Hui Liu, Mengting Che, Liyan Li, Honglei Wang, Chaomeng Wang, Junshu Wu, Yingying Chen, Zhaoyun Liu, Lijuan Li, Rong Fu   +9 more
wiley   +1 more source

The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.

PLoS Pathogens, 2008
The Gram-positive bacterium Staphylococcus aureus, similar to other pathogens, binds human complement regulators Factor H and Factor H related protein 1 (FHR-1) from human serum.
Katrin Haupt, Michael Reuter, Jean van den Elsen, Julia Burman, Steffi Hälbich, Julia Richter, Christine Skerka, Peter F Zipfel   +7 more
doaj   +1 more source