Editorial: Function and Dysfunction of Complement Factor H [PDF]
Frontiers in Immunology, 2022 Non peer ...
Mihály Józsi +2 more
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Complement factor H in molecular regulation of angiogenesis [PDF]
Medical ReviewAngiogenesis, the process of formation of new capillaries from existing blood vessels, is required for multiple physiological and pathological processes.
Li Jiang +6 more
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Factor H Autoantibodies and Complement-Mediated Diseases [PDF]
Frontiers in Immunology, 2020 Factor H (FH), a member of the regulators-of-complement-activation (RCA) family of proteins, circulates in human plasma at concentrations of 180–420 mg/L where it controls the alternative pathway (AP) of complement in the fluid phase and on cell surfaces.
Yuzhou Zhang +10 more
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Hijacking Factor H for Complement Immune Evasion [PDF]
Frontiers in Immunology, 2021 The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore +3 more
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Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H [PDF]
Frontiers in Immunology, 2020 Podocytes are an important part of the glomerular filtration barrier and the key player in the development of proteinuria, which is an early feature of complement mediated renal diseases.
Anne K. Mühlig +14 more
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Properdin and Factor H: Opposing players on the alternative complement pathway see-saw [PDF]
Frontiers in Immunology, 2013 Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilising the C3bBb complex, whereas factor H down-regulates the pathway by ...
Lubna eKouser +7 more
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Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells [PDF]
Frontiers in Immunology, 2021 Complement Factor H-Related 3 (FHR-3) is a major regulator of the complement system, which is associated with different diseases, such as age-related macular degeneration (AMD).
Nicole Schäfer +9 more
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Factor H Family Proteins in Complement Evasion of Microorganisms [PDF]
Frontiers in Immunology, 2017 Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the host complement system that may facilitate pathogen entry into cells and tissues, expression of molecules that defuse the ...
Mihály Józsi
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Differential modulation of SARS-CoV-2 infection by complement factor H and properdin [PDF]
Frontiers in ImmunologyIntroductionAn unbalanced immune response and excessive inflammation are the major hallmarks of severe SARS-CoV-2 infection, which can result in multiorgan failure and death. The dysregulation of the complement system has been shown in various studies as
Uday Kishore +17 more
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Is Complement Factor H Tyr402His Variant a Potential Cause of Ankylosing Spondylitis?
Haseki Tıp Bülteni, 2020 Aim:Ankylosing spondylitis (AS) is an autoimmune disease caused by chronic inflammatory response. Complement system is the major component of the innate immune defence. In this study, we investigated the potential association between complement factor H (
Sacide Pehlivan +4 more
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