Results 41 to 50 of about 2,568,825 (335)
Complement factors (H) into thrombosis [PDF]
Blood, 2017 In this issue of Blood, Ueda et al demonstrate that a mutation in factor H (FH) disrupts host cell interactions, leading to dysregulation of complement, systemic thrombotic angiopathy, and hemolytic uremic syndrome ...
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Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein [PDF]
, 2012 Human complement factor H-related protein (CFHR) 4 belongs to the factor H family of plasma glycoproteins that are composed of short consensus repeat (SCR) domains.
Hebecker, Mario, Józsi, Mihály
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Factor H Family Proteins in Complement Evasion of Microorganisms
Frontiers in Immunology, 2017 Human-pathogenic microbes possess various means to avoid destruction by our immune system. These include interactions with the host complement system that may facilitate pathogen entry into cells and tissues, expression of molecules that defuse the ...
Mihály Józsi
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Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Dysregulation of the alternative complement pathway due to impaired binding of complement factor H (CFH) to self-ligands or altered self-ligands (e.g.
Lejla Alic +12 more
semanticscholar +1 more source
Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]
, 2012 Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Hammerschmidt, Claudia +6 more
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Factor H complements AMD [PDF]
Science-Business eXchange, 2011 EU and U.S. researchers have revealed what could be the mechanistic underpinnings of the increased risk for age-related macular degeneration in individuals with a common polymorphism in the gene for complement factor H.
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Alternative Pathway Dysregulation and the Conundrum of Complement Activation by IgG4 Immune Complexes in Membranous Nephropathy [PDF]
, 2016 Membranous nephropathy (MN), a major cause of nephrotic syndrome, is a non-inflammatory immune kidney disease mediated by IgG antibodies that form glomerular subepithelial immune complexes.
Dorin-Bogdan Borza
core +5 more sources
PLoS ONE, 2021 Exosomes are a class of extracellular vesicles (EVs) that are mediators of normal intercellular communication, but exosomes are also used by tumor cells to promote oncogenesis and metastasis.
Ryan T Bushey +3 more
doaj +1 more source
Factor H preserves alternative complement function during ARDS, linked to improved survival
ERJ Open Research, 2023 Background Effective regulation of complement activation may be crucial to preserving complement function during acute respiratory distress syndrome (ARDS). Factor H is the primary negative regulator of the alternative pathway of complement.
William Bain +11 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The complement factor H (CFH) Y402H polymorphism (rs1061170) imparts the strongest risk for age-related macular degeneration (AMD), the leading cause of blindness in the elderly.
M. Landowski +6 more
semanticscholar +1 more source