Results 41 to 50 of about 349,286 (299)

Interaction of complement factor h and fibulin3 in age-related macular degeneration. [PDF]

PLoS ONE, 2013
Age-related macular degeneration (AMD) is a major cause of vision loss. It is associated with development of characteristic plaque-like deposits (soft drusen) in Bruch's membrane basal to the retinal pigment epithelium (RPE).
M Keith Wyatt, Jen-Yue Tsai, Sanghamitra Mishra, Maria Campos, Cynthia Jaworski, Robert N Fariss, Steven L Bernstein, Graeme Wistow   +7 more
doaj   +1 more source

Structural basis for complement factor H-linked age-related macular degeneration

, 2007
Nearly 50 million people worldwide suffer from age-related macular degeneration (AMD), which causes severe loss of central vision. A single-nucleotide polymorphism in the gene for the complement regulator factor H (FH), which causes a Tyr-to-His ...
Pietro Roversi, Clark, S, Robert B. Sim, Susan M. Lea, Jowitt, Thomas A., Beverly E. Prosser, Prosser, Beverly E., Prosser, B, Day, Anthony J., Herbert, AP, Dušan Uhrín, Sim, Robert B., Uhrin, Dusan, Barlow, P, Johnson, S, Lea, SM, Steven Johnson, Blaum, Barbel S., Barlow, Paul N., Herbert, A, Barlow, PN, Sim, RB, Simon J. Clark, Roversi, P, Uhrín, D, Johnson, Steven, Thomas A. Jowitt, Day, A, Jowitt, Thomas A.; id_orcid, Edward Tarelli, Jess Tyrrell, Lea, Susan M., Tyrrell, J, Blaum, BS, Herbert, Andrew P., Clark, Simon J., Tyrrell, Jess, Day, Anthony J.; id_orcid, Lea, Susan, Tarelli, E, Clark, SJ, Paul N. Barlow, Bärbel S. Blaum, Clark, Simon; id_orcid, Tarelli, Edward, Prosser, BE, Jowitt, TA, Day, AJ, Andrew P. Herbert, Roversi, Pietro, Anthony J. Day   +50 more
core   +1 more source

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components

, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Christine Skerka, Skerka, Christine, Schwab, Jasmin, Peter Kraiczy (36173), Jasmin Schwab (105418), Christine Skerka (105424), Zipfel, Peter F., Richter, Dania, Peter Kraiczy, Peter F Zipfel, Dania Richter (105422), Franz-Rainer Matuschka, Peter F. Zipfel, Kraiczy, Peter, Reinhard Wallich (57833), Matuschka, Franz-Rainer, Dania Richter, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Reinhard Wallich, Jasmin Schwab, Claudia Hammerschmidt (105420), Peter F. Zipfel (105431), Franz-Rainer Matuschka (105426)   +24 more
core   +1 more source

Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages

Frontiers in Immunology, 2018
The alternative pathway (AP) of complement is constantly active in plasma and can easily be activated on self surfaces and trigger local inflammation. Host cells are protected from AP attack by Factor H (FH), the main AP regulator in plasma.
Eija Nissilä, Pipsa Hakala, Katarzyna Leskinen, Angela Roig, Shahan Syed, Kok P. M. Van Kessel, Jari Metso, Carla J. C. De Haas, Päivi Saavalainen, Seppo Meri, Angeliki Chroni, Jos A. G. Van Strijp, Katariina Öörni, Matti Jauhiainen, T. Sakari Jokiranta, Karita Haapasalo   +15 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Carbohydrate recognition and complement activation by rat ficolin-B [PDF]

, 2010
Ficolins are innate immune components that bind to PAMPs and structures on apoptotic cells. Humans produce two serum forms (L-and H-ficolin) and a leukocyte-associated form (M-ficolin), whereas rodents and most other mammals produce ficolins-A and -B ...
Roscher, Silke, Umakhanth Venkatraman Girija, Russell Wallis, Mitchell, Daniel A., Girija, Umakhanth Venkatraman, Wallis, Russell, Wallis, R., Mitchell, D. A., Venkatraman Girija, U., Roscher, S., Daniel A. Mitchell, Silke Roscher   +11 more
core   +1 more source

Genetic Risk in Families with Age-Related Macular Degeneration

Ophthalmology Science, 2021
Purpose: To determine the contribution of common and rare genetic risk variants in families with age-related macular degeneration (AMD). Design: Case-control study.
Anita de Breuk, MD, Yara T.E. Lechanteur, MD, PhD, Thomas J. Heesterbeek, MD, PhD, Sascha Fauser, MD, PhD, Caroline C.W. Klaver, MD, PhD, Carel B. Hoyng, MD, PhD, Anneke I. den Hollander, PhD   +6 more
doaj   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH

Frontiers in Immunology
Factor H-related proteins (FHRs) are found in mice, but their equivalence to human FHRs remains uncertain. This study identifies three FHRs in mouse plasma (FHR-B, FHR-C, and FHR-E) and focuses on characterizing FHR-B.
Adrián Martín-Ambrosio Doménech, Silvia González Sanz, Bárbara Márquez Tirado, Lucia Juana-López, Elena Goicoechea de Jorge, Santiago Rodríguez de Córdoba, Héctor Martín Merinero   +6 more
doaj   +1 more source

Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE

Frontiers in Immunology, 2023
Factor I (FI) is an essential regulator of the complement system. Together with co-factors, FI degrades C3b, which inhibits further complement activation.
Alexandra Gerogianni, Alexandra Gerogianni, Laura M. Baas, Dick J. Sjöström, Dick J. Sjöström, Nicole C. A. J. van de Kar, Marit Pullen, Siem J. van de Peppel, Per H. Nilsson, Per H. Nilsson, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel, Lambertus P. van den Heuvel   +13 more
doaj   +1 more source