FHR-1 binds to C-reactive protein and enhances rather than inhibits complement activation [PDF]
, 2017 Factor H (FH)-related protein 1 (FHR-1) is one of the five human factor H-related proteins, which share sequence and structural homology with the alternative pathway complement inhibitor FH.
Bánlaki, Zsófia +7 more
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Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice [PDF]
Kidney International, 2010 Total deficiency of complement factor H (CFH) is associated with dense deposit disease and atypical hemolytic uremic syndrome. CFH is the major regulator of the alternative pathway of complement activation and its complete deficiency results in uncontrolled C3 activation through this pathway and secondary C3 deficiency.
Fakhouri, Fadi +5 more
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Anesthetic management of living donor liver transplantation for complement factor H deficiency hemolytic uremic syndrome: a case report [PDF]
Korean Journal of Anesthesiology, 2014 We experienced a living donor liver transplantation for a 26-month-old girl with complement factor H deficiency. Complement factor H is a plasma protein that regulates the activity of the complement pathway.
Suk-Hee Park, Gaab-Soo Kim
doaj +1 more source
Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions
Frontiers in Immunology, 2021 Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of complement has recently been emerging. Factor H (FH), the main regulator of the alternative pathway of complement activation, has been reported to bind to ...
Éva Kárpáti +7 more
doaj +1 more source
Kidney International, 2018 IgA nephropathy (IgAN) is a disease associated with activation of the complement system. But the factors influencing complement activation in IgAN are not fully understood.
Li Zhu +8 more
semanticscholar +1 more source
Translational Mini-Review Series on Complement Factor H: Genetics and disease associations of human complement factor H [PDF]
Clinical and Experimental Immunology, 2007 SummaryOTHER ARTICLES PUBLISHED IN THIS TRANSLATIONAL MINI-REVIEW SERIES ON COMPLEMENT FACTOR HStructural and functional correlations for factor H. Clin Exp Immunol 2008; 151: doi:10.1111/j.1365-2249.2007.03553.xTherapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative ...
Rodríguez de Córdoba, Santiago +1 more
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Is Complement Factor H Tyr402His Variant a Potential Cause of Ankylosing Spondylitis?
Haseki Tıp Bülteni, 2020 Aim:Ankylosing spondylitis (AS) is an autoimmune disease caused by chronic inflammatory response. Complement system is the major component of the innate immune defence. In this study, we investigated the potential association between complement factor H (
Sacide Pehlivan +4 more
doaj +1 more source
Planar posets have dimension at most linear in their height
, 2017 We prove that every planar poset $P$ of height $h$ has dimension at most $192h + 96$. This improves on previous exponential bounds and is best possible up to a constant factor.
Joret, Gwenaël +2 more
core +1 more source
Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits
Frontiers in Immunology, 2020 Complement-mediated inflammation or dysregulation in lipid metabolism are associated with the pathogenesis of several diseases. These include age-related macular degeneration (AMD), C3 glomerulonephritis (C3GN), dense deposit disease (DDD ...
S. Meri, K. Haapasalo
semanticscholar +1 more source
Mouse Podocyte Complement Factor H [PDF]
Journal of the American Society of Nephrology, 2007 Complement factor H (Cfh) is a key plasma protein in humans and animals that serves to limit alternative pathway complement activation in plasma, as well as in local sites such as capillaries of the glomerulus and eye. It was shown that rodent Cfh on platelets is the functional analogue to human erythrocyte complement receptor 1 with a role that is ...
Jessy J, Alexander +7 more
openaire +2 more sources