Results 51 to 60 of about 16,352,795 (292)

Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings [PDF]

, 2011
Characterization of segmental flexibility is needed to understand the biological mechanisms of the very large category of functionally diverse proteins, exemplified by the regulators of complement activation, that consist of numerous compact modules or ...
Maciejewski, Mateusz, Barlow, Paul N., Tjandra, Nico, Nico Tjandra, Paul N. Barlow, Mateusz Maciejewski   +5 more
core   +1 more source

Interaction of complement factor h and fibulin3 in age-related macular degeneration. [PDF]

PLoS ONE, 2013
Age-related macular degeneration (AMD) is a major cause of vision loss. It is associated with development of characteristic plaque-like deposits (soft drusen) in Bruch's membrane basal to the retinal pigment epithelium (RPE).
M Keith Wyatt, Jen-Yue Tsai, Sanghamitra Mishra, Maria Campos, Cynthia Jaworski, Robert N Fariss, Steven L Bernstein, Graeme Wistow   +7 more
doaj   +1 more source

Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages

Frontiers in Immunology, 2018
The alternative pathway (AP) of complement is constantly active in plasma and can easily be activated on self surfaces and trigger local inflammation. Host cells are protected from AP attack by Factor H (FH), the main AP regulator in plasma.
Eija Nissilä, Pipsa Hakala, Katarzyna Leskinen, Angela Roig, Shahan Syed, Kok P. M. Van Kessel, Jari Metso, Carla J. C. De Haas, Päivi Saavalainen, Seppo Meri, Angeliki Chroni, Jos A. G. Van Strijp, Katariina Öörni, Matti Jauhiainen, T. Sakari Jokiranta, Karita Haapasalo   +15 more
doaj   +1 more source

Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH

Frontiers in Immunology
Factor H-related proteins (FHRs) are found in mice, but their equivalence to human FHRs remains uncertain. This study identifies three FHRs in mouse plasma (FHR-B, FHR-C, and FHR-E) and focuses on characterizing FHR-B.
Adrián Martín-Ambrosio Doménech, Silvia González Sanz, Bárbara Márquez Tirado, Lucia Juana-López, Elena Goicoechea de Jorge, Santiago Rodríguez de Córdoba, Héctor Martín Merinero   +6 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

The complete amino acid sequence of human complement factor H

, 1988
The complete amino acid sequence of the human complement system regulatory protein, factor H, has been derived from sequencing three overlapping cDNA clones.
Sim, R. B., Day, A. J.; id_orcid, Ripoche, J., Harris, T. J R   +3 more
core   +6 more sources

Genetic Risk in Families with Age-Related Macular Degeneration

Ophthalmology Science, 2021
Purpose: To determine the contribution of common and rare genetic risk variants in families with age-related macular degeneration (AMD). Design: Case-control study.
Anita de Breuk, MD, Yara T.E. Lechanteur, MD, PhD, Thomas J. Heesterbeek, MD, PhD, Sascha Fauser, MD, PhD, Caroline C.W. Klaver, MD, PhD, Carel B. Hoyng, MD, PhD, Anneke I. den Hollander, PhD   +6 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Complement Factor H: solution structures and interactions with ligands [PDF]

, 2009
Factor H (FH) is a plasma glycoprotein that plays a central role in regulating the alternative pathway of complement. It is composed of 20 short complement regulator (SCR) domains.
Okemefuna, A.I.
core