Results 31 to 40 of about 2,568,825 (335)

Structural modelling of human complement FHR1 and two of its synthetic derivatives provides insight into their in-vivo functions

Computational and Structural Biotechnology Journal, 2023
Human complement is the first line of defence against invading pathogens and is involved in tissue homeostasis. Complement-targeted therapies to treat several diseases caused by a dysregulated complement are highly desirable.
Natalia Ruiz-Molina, Juliana Parsons, Eva L. Decker, Ralf Reski   +3 more
doaj   +1 more source

Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells

Scientific Reports, 2020
Polymorphisms in the Complement Factor H (CFH) gene, coding for the Factor H protein (FH), can increase the risk for age-related macular degeneration (AMD).
A. Armento, Sabina Honisch, Vasiliki Panagiotakopoulou, Inga Sonntag, Anke Jacob, S. Bolz, E. Kilger, M. Deleidi, Simon J. Clark, M. Ueffing   +9 more
semanticscholar   +1 more source

Clinical relevance of glomerular IgM deposition in patients with lupus nephritis

BMC Immunology, 2021
Background The aim of the study was to investigate the clinical relevance of IgM deposition in patients with lupus nephritis (LN) in a large cohort. Results 217 patients with renal biopsy-proven active LN were enrolled.
Fengmei Wang, Jirong Yu, Lei Zhang, Yan Zhang, Jie Zhang, Bicheng Liu, Xiaowei Yang   +6 more
doaj   +1 more source

Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies

Frontiers in Immunology, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Markus A. Loeven, Marissa L. Maciej-Hulme, Cansu Yanginlar, Melanie C. Hubers, Edwin Kellenbach, Mark de Graaf, Toin H. van Kuppevelt, Jack Wetzels, Ton J. Rabelink, Richard J. H. Smith, Johan van der Vlag   +10 more
doaj   +1 more source

Complement factor H-deficient mice develop spontaneous hepatic tumors.

Journal of Clinical Investigation, 2020
Hepatocellular carcinoma (HCC) is difficult to detect, carries a poor prognosis, and is one of few cancers with an increasing yearly incidence. Molecular defects in complement factor H (CFH), a critical regulatory protein of the complement alternative ...
J. Laskowski, B. Renner, M. Pickering, N. Serkova, P. Smith-Jones, E. Clambey, R. Nemenoff, J. Thurman   +7 more
semanticscholar   +1 more source

Contribución de variantes funcionales y cuantitativas del Factor H y las proteínas FHRs (Factor H-Related proteins) del Complemento en patología renal

Nefrología, 2022
Resumen: El sistema del Complemento protege al organismo frente a procesos infecciosos, tumorales y autoinmunes, y requiere una regulación muy estricta para evitar una activación excesiva o inespecífica.
Irene Gómez Delgado, Pilar Sánchez-Corral   +1 more
doaj   +1 more source

Tumour extracellular vesicle‐derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement‐dependent cytotoxicity of tumour cells

Journal of Extracellular Vesicles, 2020
The complement system is involved in the immunosurveillance of pathogens and tumour cells. Proteomic profiling revealed that extracellular vesicles (EVs) released by metastatic hepatocellular carcinoma (HCC) cells contained a significant number of ...
X. Mao, Longyin Zhou, S. K. Tey, A. Ma, Cherlie Lot Sum Yeung, T. Ng, S. Wong, Bonnie Hei Man Liu, Y. M. E. Fung, E. Patz, P. Cao, Yi Gao, J. Yam   +12 more
semanticscholar   +1 more source

Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children

Frontiers in Immunology, 2018
Complement is activated as part of the innate immune defense against invading pathogens. Also, it helps to remove apoptotic debris and immune complexes from the circulation.
Anna E. van Beek, Anna E. van Beek, Angela Kamp, Simone Kruithof, Ed J. Nieuwenhuys, Diana Wouters, Ilse Jongerius, Theo Rispens, Taco W. Kuijpers, Taco W. Kuijpers, Kyra A. Gelderman   +10 more
doaj   +1 more source

Human complement factor H. Two factor H proteins are derived from alternatively spliced transcripts [PDF]

, 1991
The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are ...
Alsenz, Alsenz, Aruffo, Chirgwin, Church, Conrad, Day, Feinberg, Fontaine, Kristensen, Laemmli, Maniatis, McAleer, Misasi, Pangburn, Ripoche, Schulz, Schulz, Schwaeble, Seed, Sim, Towbin, Whaley, Whaley   +23 more
core   +1 more source

Truncated forms of human complement factor H [PDF]

Biochemical Journal, 1989
By the use of Western-blot analyses with polyclonal anti-(Factor H) antibodies, two low-Mr protein species of Mr 41,000 and 37,000 under non-reducing conditions and 43,000 and 40,000 under reducing conditions are consistently detected together with the well-known 155,000-Mr Factor H in human plasma and serum. These two additional species are also found
Fontaine, M., Demares, M. J., Koistinen, V., Day, A. J., Davrinche, C., Sim, R. B., Ripoche, J.   +6 more
openaire   +3 more sources