Human Factor H (FH) Impairs Protective Meningococcal Anti-FHbp Antibody Responses and the Antibodies Enhance FH Binding [PDF]
mBio, 2014 The meningococcal 4CMenB vaccine (Bexsero; Novartis) contains four antigens that can elicit serum bactericidal activity, one of which is factor H (FH)-binding protein (FHbp). FHbp specifically binds human complement FH. When humans are immunized, FHbp is
Isabella Costa +2 more
doaj +4 more sources
Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH). [PDF]
PLoS ONE, 2012 Factor H (FH) is a soluble regulator of the human complement system affording protection to host tissues. It selectively inhibits amplification of C3b, the activation-specific fragment of the abundant complement component C3, in fluid phase and on self ...
Hugh P Morgan +8 more
doaj +6 more sources
An Evaluation of the Complement-Regulating Activities of Human Complement Factor H (FH) Variants Associated With Age-Related Macular Degeneration. [PDF]
Invest Ophthalmol Vis Sci, 2022 Factor H (FH, encoded by CFH) prevents activation of the complement system's alternative pathway (AP) on host tissues. FH impedes C3 convertase (C3bBb) formation, accelerates C3bBb decay, and is a cofactor for factor I (FI)-catalyzed C3b cleavage. Numerous CFH variants are associated with age-related macular degeneration (AMD), but their functional ...
Biggs RM +5 more
europepmc +4 more sources
Characterization of Diverse Subvariants of the Meningococcal Factor H (fH) Binding Protein for Their Ability To Bind fH, To Mediate Serum Resistance, and To Induce Bactericidal Antibodies [PDF]
Infection and Immunity, 2011 Neisseria meningitidis is a commensal of the human nasopharynx but is also a major cause of septicemia and meningitis. The meningococcal factor H binding protein (fHbp) binds human factor H (fH), enabling downregulation of complement activation on the ...
L. Seib, Kate +15 more
core +5 more sources
Binding of Complement Factor H (FH) Decreases Protective Anti-FH Binding Protein Antibody Responses of Infant Rhesus Macaques Immunized With a Meningococcal Serogroup B Vaccine. [PDF]
J Infect Dis, 2015 The meningococcal vaccine antigen, factor H (FH)-binding protein (FHbp), binds human complement FH. In human FH transgenic mice, binding decreased protective antibody responses.To investigate the effect of primate FH binding, we immunized rhesus macaques with a 4-component serogroup B vaccine (4CMenB). Serum FH in 6 animals bound strongly to FHbp (FHbp-
Granoff DM +5 more
europepmc +5 more sources
Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton [PDF]
Communications BiologyOverexpression of complement genes in the tumor microenvironment, including Factor H (FH), is a strong predictor of poor prognosis in multiple cancers. Its canonical functions in the bloodborne complement cascade, though, cannot explain this prognostic ...
Mikel Rezola Artero +18 more
doaj +2 more sources
Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces
Frontiers in Immunology, 2021 To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators.
Arthur Dopler +10 more
doaj +1 more source
A Family Affair: Addressing the Challenges of Factor H and the Related Proteins
Frontiers in Immunology, 2021 Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders.
Felix Poppelaars +11 more
doaj +1 more source
Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic. [PDF]
PLoS ONE, 2012 Similar to other highly successful invasive bacterial pathogens, Staphylococcus aureus recruits the complement regulatory protein factor H (fH) to its surface to inhibit the alternative pathway of complement.
Julia A Sharp +7 more
doaj +1 more source
Binding of Complement Factor H (fH) to Neisseria meningitidis Is Specific for Human fH and Inhibits Complement Activation by Rat and Rabbit Sera [PDF]
Infection and Immunity, 2009 ABSTRACT Complement factor H (fH), a molecule that downregulates complement activation, binds to Neisseria meningitidis and increases resistance to serum bactericidal activity. We investigated the species specificity of fH binding and the effect of human fH on downregulating
Dan M, Granoff +2 more
openaire +2 more sources