Results 1 to 10 of about 1,628,545 (288)

Identification of the Gene Encoding the FhbB Protein ofTreponema denticola, a Highly Unique Factor H-Like Protein 1 Binding Protein [PDF]

Infection and Immunity, 2007
ABSTRACTThe gene encoding theTreponema denticolafactor H-like protein 1 (FHL-1) binding protein, FhbB, was recovered and characterized. Sequence conservation, expression, and properties of FhbB were analyzed. The identification of FhbB represents an important step in understanding the contribution of FHL-1 binding inT.
John V, McDowell, Jesse, Frederick, Lola, Stamm, Richard T, Marconi   +3 more
core   +7 more sources

C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation. [PDF]

Sci Rep, 2018
AbstractRetinal inflammation plays a key role in the progression of age-related macular degeneration (AMD), a condition that leads to loss of central vision. The deposition of the acute phase pentraxin C-reactive protein (CRP) in the macula activates the complement system, thereby contributing to dysregulated inflammation. The complement protein factor
Swinkels M, Zhang JH, Tilakaratna V, Black G, Perveen R, McHarg S, Inforzato A, Day AJ, Clark SJ.   +8 more
europepmc   +3 more sources

Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration. [PDF]

J Immunol, 2014
Abstract The tight regulation of innate immunity on extracellular matrix (ECM) is a vital part of immune homeostasis throughout the human body, and disruption to this regulation in the eye is thought to contribute directly to the progression of age-related macular degeneration (AMD).
Clark SJ, Schmidt CQ, White AM, Hakobyan S, Morgan BP, Bishop PN.   +5 more
europepmc   +5 more sources

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation. [PDF]

J Immunol, 2016
Abstract The serum proteins factor H (FH), consisting of 20 complement control protein modules (CCPs), and its splice product FH-like protein 1 (FHL-1; consisting of CCPs 1–7) are major regulators of the alternative pathway (AP) of complement activation.
Harder MJ, Anliker M, Höchsmann B, Simmet T, Huber-Lang M, Schrezenmeier H, Ricklin D, Lambris JD, Barlow PN, Schmidt CQ.   +9 more
europepmc   +4 more sources

A Family Affair: Addressing the Challenges of Factor H and the Related Proteins

Frontiers in Immunology, 2021
Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders.
Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius, Ilse Jongerius, Antje J. Baeumner, Mark-Steven Steiner, Mihály Józsi, Mihály Józsi, Erik J. M. Toonen, Diana Pauly, Diana Pauly, the SciFiMed consortium   +11 more
doaj   +1 more source

Beyond factor H: The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations [PDF]

The American Journal of Human Genetics, 2021
Age-related macular degeneration (AMD) is a leading cause of vision loss; there is strong genetic susceptibility at the complement factor H (CFH) locus. This locus encodes a series of complement regulators: factor H (FH), a splice variant factor-H-like 1 (FHL-1), and five factor-H-related proteins (FHR-1 to FHR-5), all involved in the regulation of ...
Cipriani, Valentina, Tierney, Anna, Griffiths, John R, Zuber, Verena, Sergouniotis, Panagiotis I, Yates, John R W, Moore, Anthony T, Bishop, Paul N, Clark, Simon J, Unwin, Richard D   +9 more
openaire   +5 more sources

Molecular Analyses of the Interaction ofBorrelia hermsiiFhbA with the Complement Regulatory Proteins Factor H and Factor H-Like Protein 1 [PDF]

Infection and Immunity, 2006
ABSTRACTBorrelia hermsii, the primary etiological agent of tick-borne relapsing fever in North America, binds the complement regulatory protein factor H (FH) as a means of evading opsonophagocytosis and the alternative complement pathway. The ability of FH-binding protein A (FhbA) to bind FH-like protein 1 (FHL-1) has not been assessed previously.
Kelley M, Hovis, Janice P, Jones, Tania, Sadlon, Gauri, Raval, David L, Gordon, Richard T, Marconi   +5 more
openaire   +5 more sources

Plasma proteomic profiling of bacterial cold water disease-resistant and -susceptible rainbow trout lines and biomarker discovery

Frontiers in Immunology, 2023
Genetic variation for disease resistance is present in salmonid fish; however, the molecular basis is poorly understood, and biomarkers of disease susceptibility/resistance are unavailable.
Gregory D. Wiens, David P. Marancik, Christopher C. Chadwick, Keira Osbourn, Ross M. Reid, Timothy D. Leeds   +5 more
doaj   +1 more source

Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells

Immunobiology, 2023
Factor H is a pivotal complement regulatory protein that is preferentially produced by the liver and circulates in high concentrations in serum. There has been an increasing interest in the extrahepatic production of complement factors, including by cells of the immune system, since this contributes to non-canonical functions of local complement ...
Essen, M.F. van, Peereboom, E.T.M., Schlagwein, N., Gijlswijk-Janssen, D.J. van, Nelemans, T., Joeloemsingh, J.V., Berg, C.W. van den, Prins, J., Clark, S.J., Schmidt, C.Q., Trouw, L.A., Kooten, C. van   +11 more
openaire   +4 more sources

Recruitment of Complement Factor H-Like Protein 1 Promotes Intracellular Invasion by Group A Streptococci [PDF]

Infection and Immunity, 2003
ABSTRACTNumerous microbial pathogens exploit complement regulatory proteins such as factor H (FH) and factor H-like protein 1 (FHL-1) for immune evasion. Fba is an FHL-1 and FH binding protein expressed on the surface of the human pathogenic bacterium,Streptococcus pyogenes, a common agent of pharyngeal, skin, and soft-tissue infections. In the present
Vinod, Pandiripally, Lin, Wei, Christine, Skerka, Peter F, Zipfel, David, Cue   +4 more
openaire   +2 more sources