Results 1 to 10 of about 119,277,255 (280)

A Family Affair: Addressing the Challenges of Factor H and the Related Proteins

Frontiers in Immunology, 2021
Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders.
Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius, Ilse Jongerius, Antje J. Baeumner, Mark-Steven Steiner, Mihály Józsi, Mihály Józsi, Erik J. M. Toonen, Diana Pauly, Diana Pauly, the SciFiMed consortium   +11 more
doaj   +1 more source

Plasma proteomic profiling of bacterial cold water disease-resistant and -susceptible rainbow trout lines and biomarker discovery

Frontiers in Immunology, 2023
Genetic variation for disease resistance is present in salmonid fish; however, the molecular basis is poorly understood, and biomarkers of disease susceptibility/resistance are unavailable.
Gregory D. Wiens, David P. Marancik, Christopher C. Chadwick, Keira Osbourn, Ross M. Reid, Timothy D. Leeds   +5 more
doaj   +1 more source

Tuning the Functionality by Splicing: Factor H and Its Alternative Splice Variant FHL-1 Share a Gene but Not All Functions

Frontiers in Immunology, 2020
The alternative pathway regulator Factor H-like protein 1 (FHL-1) is composed of the first 7 N-terminal complement control protein domains of Factor H (FH) and protects host surfaces from uncontrolled complement attack.
Marco Mannes, Arthur Dopler, Markus Huber-Lang, Christoph Q. Schmidt   +3 more
doaj   +1 more source

The Regulatory Role of Apelin on the Appetite and Growth of Common Carp (Cyprinus Carpio L.)

Animals, 2020
Apelin, a kind of active polypeptide, has many biological functions, such as promoting food intake, enhancing immunity, and regulating energy balance. In mammals, studies have indicated that apelin is involved in regulating food intake.
Xiao Yan, Chaobin Qin, Guokun Yang, Dapeng Deng, Liping Yang, Junchang Feng, Jiali Mi, Guoxing Nie   +7 more
doaj   +1 more source

Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. [PDF]

PLoS ONE, 2016
Complement factor H-related protein 1 (CFHR1) is a complement regulator which has been reported to regulate complement by blocking C5 convertase activity and interfering with C5b surface association. CFHR1 also competes with complement factor H (CFH) for
Jonathan P Hannan, Jennifer Laskowski, Joshua M Thurman, Gregory S Hageman, V Michael Holers   +4 more
doaj   +1 more source

Complement-Independent Modulation of Influenza A Virus Infection by Factor H

Frontiers in Immunology, 2020
The complement system is an ancient innate immune defense mechanism that can recognize molecular patterns on the invading pathogens. Factor H, as an inhibitor of the alternative pathway, down-regulates complement activation on the host cell surface ...
Valarmathy Murugaiah, Praveen M. Varghese, Praveen M. Varghese, Soad M. Saleh, Anthony G. Tsolaki, Salman H. Alrokayan, Haseeb A. Khan, Kate S. Collison, Robert B. Sim, Béatrice Nal, Futwan A. Al-Mohanna, Uday Kishore   +11 more
doaj   +1 more source

Aspf2 From Aspergillus fumigatus Recruits Human Immune Regulators for Immune Evasion and Cell Damage

Frontiers in Immunology, 2018
The opportunistic fungal pathogen Aspergillus fumigatus can cause life-threatening infections, particularly in immunocompromised patients. Most pathogenic microbes control host innate immune responses at the earliest time, already before infiltrating ...
Prasad Dasari, Iordana A. Shopova, Maria Stroe, Dirk Wartenberg, Hans Martin-Dahse, Niklas Beyersdorf, Peter Hortschansky, Stefanie Dietrich, Stefanie Dietrich, Zoltán Cseresnyés, Marc Thilo Figge, Marc Thilo Figge, Martin Westermann, Christine Skerka, Axel A. Brakhage, Axel A. Brakhage, Peter F. Zipfel, Peter F. Zipfel   +17 more
doaj   +1 more source

In vivo and in vitro protective effects of shengmai injection against doxorubicin-induced cardiotoxicity

Pharmaceutical Biology, 2022
Context Shengmai injection (SMI) has been used to treat heart failure.Objective This study determines the molecular mechanisms of SMI against cardiotoxicity caused by doxorubicin (DOX).Materials and methods In vivo, DOX (15 mg/kg) was intraperitoneally ...
Peng Zhou, Ge Gao, Chun-chun Zhao, Jing-ya Li, Jian-fei Peng, Shu-shu Wang, Rui Song, Hui Shi, Liang Wang   +8 more
doaj   +1 more source

Anti-inflammatory Effect of Lyophyllum ulmarium Fibrinolytic Enzyme on Macrophages [PDF]

Shipin Kexue
This study evaluated the anti-inflammatory effect of a fibrinolytic enzyme from Lyophyllum ulmarium (LUFE) on lipopolysaccharide-induced J774A.1 macrophages.
SU Xin, ZHANG Qing, WANG Jiayi, SHEN Minghua
doaj   +1 more source

Comparative transcriptome analysis reveals resistant and susceptible genes in tobacco cultivars in response to infection by Phytophthora nicotianae

Scientific Reports, 2021
Phytophthora nicotianae is highly pathogenic to Solanaceous crops and is a major problem in tobacco production. The tobacco cultivar Beihart1000-1 (BH) is resistant, whereas the Xiaohuangjin 1025 (XHJ) cultivar is susceptible to infection.
He Meng, Mingming Sun, Zipeng Jiang, Yutong Liu, Ying Sun, Dan Liu, Caihong Jiang, Min Ren, Guangdi Yuan, Wenlong Yu, Quanfu Feng, Aiguo Yang, Lirui Cheng, Yuanying Wang   +13 more
doaj   +1 more source