Results 21 to 30 of about 119,277,255 (280)

Impact of the SpeB Protease on Binding of the Complement Regulatory Proteins Factor H and Factor H-Like Protein 1 byStreptococcus pyogenes [PDF]

Infection and Immunity, 2005
ABSTRACTMicrobial pathogens often exploit human complement regulatory proteins such as factor H (FH) and factor H-like protein 1 (FHL-1) for immune evasion. Fba is an FH and FHL-1 binding protein expressed on the surface of the human pathogenic bacteriumStreptococcus pyogenes, a common agent of pharyngeal, skin, and soft-tissue infections. Fba has been
Lin, Wei, Vinod, Pandiripally, Eugene, Gregory, Micaya, Clymer, David, Cue   +4 more
openaire   +2 more sources

Glycerol-3-Phosphate Dehydrogenase 2 Is a Novel Factor H–, Factor H–like Protein 1–, and Plasminogen-Binding Surface Protein of Candida albicans [PDF]

The Journal of Infectious Diseases, 2012
Candida albicans uses human complement regulators such as factor H and factor H-like protein 1 (FHL-1) for immune evasion. To define the whole panel of fungal complement-evasion molecules, C. albicans cell extract was absorbed to a factor H-coupled matrix.
Shanshan, Luo, Ralf, Hoffmann, Christine, Skerka, Peter F, Zipfel   +3 more
openaire   +2 more sources

The human complement regulatory factor-H-like protein 1, which represents a truncated form of factor H, displays cell-attachment activity [PDF]

Biochemical Journal, 1997
Complement factor H (FH) and factor-H-like protein 1 (FHL-1) are human plasma proteins with regulatory functions in the alternative pathway of complement activation. FH and FHL-1 are organized in repetitive elements termed short consensus repeats (SCRs) and the seven SCRs of FHL-1 are identical with the N-terminal domain of the 20 SCRs of FH.
J, Hellwage, S, Kühn, P F, Zipfel
openaire   +2 more sources

Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi [PDF]

, 2010
Background: One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular to complement-mediated killing. Serum-resistant B.
Teresia Hallström, Hallström Teresia, Christine Skerka, Beckhaus Tobias, Skerka, Christine, Karas Michael, Hannes Eberhardt, Michael Karas, Barbara Uzonyi, Corinna Siegel, Kraiczy Peter, Eberhardt, Hannes, Uzonyi Barbara, Zipfel, Peter F., Beckhaus, Tobias, Peter Kraiczy, Karas, Michael (Prof. Dr.), Stevenson, Brian, Peter F Zipfel, Stevenson Brian, Uzonyi, Barbara, Brian Stevenson, Peter F. Zipfel, Siegel, Corinna, Hallström, Teresia, Kraiczy, Peter, Tobias Beckhaus, Eberhardt Hannes, Skerka Christine, Wallich, Reinhard, Zipfel Peter F., Reinhard Wallich, Siegel Corinna, Karas, Michael, Wallich Reinhard   +34 more
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Exceptional Resistance of Human H2 Glioblastoma Cells to Complement-Mediated Killing by Expression and Utilization of Factor H and Factor H-Like Protein 1 [PDF]

The Journal of Immunology, 2000
Abstract Of over 20 nucleated cell lines we have examined to date, human H2 glioblastoma cells have turned out to be the most resistant to complement-mediated cytolysis in vitro. H2 cells expressed strongly the membrane attack complex inhibitor protectin (CD59), moderately CD46 (membrane cofactor protein) and CD55 (decay-accelerating ...
S, Junnikkala, T S, Jokiranta, M A, Friese, H, Jarva, P F, Zipfel, S, Meri   +5 more
openaire   +2 more sources

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A., Reading, Patrick   +25 more
core   +1 more source

Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction [PDF]

, 2011
Introduction: In this study, we compared insulin-like growth factor (IGF)-gene expression patterns and characteristics of glucose and insulin metabolism in human placenta from pregnancies with or without intrauterine growth restriction (IUGR).
Tóth, Katalin, Börzsönyi Balázs, Demendi Csaba, Balázs Börzsönyi, Börzsönyi, Balázs, Tóth Katalin, János Rigó Jr, Pajor, Attila, Rigó, János, Joó József, Gábor, Zsolt Nagy, Csaba Demendi, Rigó János, Pajor Attila, Mónika Csanád, Katalin Tóth, Demendi, Csaba, Csanád, Mónika, Nagy, Zsolt, Attila Pajor, József Gábor Joó, Nagy Zsolt, Csanád Mónika, Joó József Gábor   +23 more
core   +1 more source

Human PathogenicBorrelia spielmaniisp. nov. Resists Complement-Mediated Killing by Direct Binding of Immune Regulators Factor H and Factor H-Like Protein 1 [PDF]

Infection and Immunity, 2007
ABSTRACTBorrelia spielmaniisp. nov. has recently been shown to be a novel human pathogenic genospecies that causes Lyme disease in Europe. In order to elucidate the immune evasion mechanisms ofB. spielmanii, we compared the abilities of isolates obtained from Lyme disease patients and tick isolate PC-Eq17 to escape from complement-mediated ...
Herzberger, Pia, Siegel, Corinna, Skerka, Christine, Fingerle, Volker, Schulte-Spechtel, Ulrike, van Dam, Alje, Wilske, Bettina, Brade, Volker, Zipfel, Peter F., Wallich, Reinhard, Kraiczy, Peter   +10 more
openaire   +3 more sources

Estradiol, Progesterone, and Transforming Growth Factor α Regulate Insulin-Like Growth Factor Binding Protein-3 (IGFBP3) Expression in Mouse Endometrial Cells [PDF]

, 2009
Insulin-like growth factor 1 (IGF1) Is Involved in the proliferation of mouse and rat endometrial cells in a paracrine or autocrine manner. Insulin-like growth factor binding protein-3 (IGFBP3) modulates actions of IGFs directly or indirectly.
Takahashi, Sumio, Takeuchi, Sakae, Kanayama, Munetoshi, Maekawa, Tetsuya   +3 more
core   +1 more source

Human Complement Factor H and Factor H-Like Protein 1 Are Expressed in Human Retinal Pigment Epithelial Cells

Ophthalmic Research, 2013
<b><i>Background:</i></b> A common haplotype in the gene for the regulator of the alternative pathway of complement activation factor H has been linked to individual predisposition to age- related macular degeneration (AMD). <b><i>Methods:</i></b> In this study, retinal pigment epithelial (RPE) cells, i.e.
Weinberger, Andreas, Eddahabi, Cordula, Carstesen, Dörthe, Zipfel, Peter F, Walter, Peter, Skerka, Christine   +5 more
openaire   +3 more sources