Results 1 to 10 of about 108,098 (261)

CONSUMPTION OF BROCCOLI SPROUTS INCREASED THE ACTIVITY OF GLUTATHIONE-DEPENDENT ANTIOXIDANT ENZYMES IN MURINE LIVER [PDF]

Biotechnologia Acta, 2023
Aim. The purpose of this work was to investigate effects of the consumption of broccoli sprouts on the activity of antioxidant defense enzymes in the liver of. GPx isoforms.
M.V. IVANOCHKO, O.I. DEMIANCHUK, M.M. BAYLIAK, V.I. LUSHCHAK   +3 more
doaj   +1 more source

The effect of 12 weeks of aerobic exercise and caloric restriction on Nrf2 protein expression in non-alcoholic fatty liver disease in rats [PDF]

Journal of Shahrekord University of Medical Sciences, 2023
Background and aims: One of the most common causes of liver disease is non-alcoholic fatty liver disease (NAFLD), and its prevalence along with serious clinical problem is a growing. No studies have been conducted on the effect of calorie restriction (CR)
Farzaneh Yadegari, Farhad Rahmani Nia
doaj   +1 more source

Research advances in the protective effect of sulforaphane against kidney injury and related mechanisms [PDF]

BIO Web of Conferences, 2022
Kidney injury and related diseases have become quite common in recent years, and have attracted more attention. Sulforaphane, a kind of isothiocyanate, is widely distributed in cruciferous plants and it is a common antioxidant. Specifically, sulforaphane
Chang Ruoxi
doaj   +1 more source

Neuroprotective effect of L-deprenyl on the expression level of the Mst1 gene and inhibition of apoptosis in rat-model spinal cord injury [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): After primary tissue damage as a result of spinal cord injury (SCI), there is a period of secondary damage, which includes several cellular and inflammatory biochemical cascades.
Alireza Abdanipour, Ali Nikfar, Mahsa Nikbakht Rad, Iraj Jafari Anarkooli, Mojdeh Mansouri   +4 more
doaj   +1 more source

N-terminal 5-mer peptide analog P165 of amyloid precursor protein repairs skin photodamage induced by UVB through the Nrf2 signaling pathway

Indian Journal of Dermatology, 2021
Background: Acute photodamage is an acute inflammatory reaction of the skin after ultraviolet (UV) irradiation. Many drugs have been successfully used for the treatment and prevention of photodamage.
Li He, Changlin Sui, Jiangbin Li, Yingying Yao, Man Li, Rong Wang, Wei Zhu   +6 more
doaj   +1 more source

AM1638, a GPR40-Full Agonist, Inhibited Palmitate-Induced ROS Production and Endoplasmic Reticulum Stress, Enhancing HUVEC Viability in an NRF2-Dependent Manner [PDF]

Endocrinology and Metabolism, 2023
Background G protein-coupled receptor 40 (GPR40) is a key molecule in diabetes and fatty liver, but its role in endothelial dysfunction remains unclear. Our objective in this study was to determine whether GPR40 agonists protect endothelial cells against
Hwan-Jin Hwang, Joo Won Kim, SukHwan Yun, Min Jeong Park, Eyun Song, Sooyeon Jang, Ahreum Jang, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo   +9 more
doaj   +1 more source

Nephroprotective Role of Combined Sitagliptin and Oleuropein in Cisplatin-Induced Acute Kidney Injury: Regulation of SDF-1α/Nrf2/ HO-1 Axis and Autophagy

Archives of Pharmaceutical Sciences Ain Shams University, 2021
Background: Accumulating evidence proves that cisplatin, a widely used anticancer, causes acute kidney injury (AKI). Sitagliptin (Sita), a dipeptidyl peptidase-4 (DPP4) inhibitor, is a hypoglycemic agent that can promote tissue angiogenesis and cell ...
Mohamed Bassiony, Nesreen O Omar, Amira M Badr, Nadia M Hamdy, Eman F Sanad   +4 more
doaj   +1 more source

Autophagy and liver cancer [PDF]

Clinical and Molecular Hepatology, 2020
Autophagy is a highly conserved catabolic process that degrades cytosolic proteins and organelles via formation of autophagosomes that fuse with lysosomes to form autolysosomes, whereby autophagic cargos are degraded.
Xiaojuan Chao, Hui Qian, Shaogui Wang, Sam Fulte, Wen-Xing Ding   +4 more
doaj   +1 more source

Potential of isothiocyanate sulforaphane from broccoli to combat obesity and type 2 diabetes: involvement of NRF2 regulatory pathway [PDF]

The Ukrainian Biochemical Journal
Biologically active food components are now considered to be remedies for the prevention and treatment of metabolic disorders of different etiology. The aim of this review was to analyze the current data on the application of isothiocyanate sulforaphane,
M. V. Ivanochko, M. M. Bayliak, V. I. Lushchak   +2 more
doaj   +1 more source

Carvacrol Ameliorating Effects on Trimethyltin Chloride-Induced Neurotoxicity by Modulating the Interplay between Nrf2/Keap1/ARE Pathway and Sirt1 [PDF]

Research Journal of Pharmacognosy, 2022
Background and objectives: Trimethyltin chloride (TMT) is a chemical with neurotoxic effects on central nervous system. Carvacrol is a phenolic monoterpenoid with antioxidative properties derived from oregano, thyme, and other plants. We aimed to explore
Farzaneh Babak, Sadegh Rajabi, Mohammad Hasan Sakhaie, Farideh Jalali-Mashayekhi*   +3 more
doaj   +1 more source