Results 1 to 10 of about 197,106 (353)

The Pivotal Role of Nrf2 Signal Axis in Intervertebral Disc Degeneration

Journal of Inflammation Research, 2023
Chunran Pan,* Wenjie Hou,* Xiaofeng Deng, Jiawei Liu, Ruimin Chi, Xingru Shang, Tao Xu, Xiaoxia Hao Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s ...
Pan C, Hou W, Deng X, Liu J, Chi R, Shang X, Xu T, Hao X   +7 more
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Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling

Drug Design, Development and Therapy, 2020
Mohammed F Alotaibi,1 Fakhria Al-Joufi,2 Howida S Abou Seif,3 Mohammed A Alzoghaibi,1 Laiche Djouhri,4 Ahmad F Ahmeda,5 Ayman M Mahmoud6 1Physiology Department, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia; 2Department of ...
Alotaibi MF, Al-Joufi F, Abou Seif HS, Alzoghaibi MA, Djouhri L, Ahmeda AF, Mahmoud AM   +6 more
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Honey and Chamomile Activate Keratinocyte Antioxidative Responses via the KEAP1/NRF2 System

Clinical, Cosmetic and Investigational Dermatology, 2020
Tatsuya Ogawa, 1 Yosuke Ishitsuka, 1 Yoshiyuki Nakamura, 1 Naoko Okiyama, 1 Rei Watanabe, 1, 2 Yasuhiro Fujisawa, 1 Manabu Fujimoto 1, 2 1Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan; 2Department of ...
Ogawa T, Ishitsuka Y, Nakamura Y, Okiyama N, Watanabe R, Fujisawa Y, Fujimoto M   +6 more
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Docosahexaenoic Acid Induces Expression of Heme Oxygenase-1 and NAD(P)H:quinone Oxidoreductase through Activation of Nrf2 in Human Mammary Epithelial Cells

Molecules, 2017
Docosahexaenoic acid (DHA), an ω-3 fatty acid abundant in fish oils, has diverse health beneficial effects, such as anti-oxidative, anti-inflammatory, neuroprotective, and chemopreventive activities. In this study, we found that DHA induced expression of
Hye-Yoon Bang, Sin-Aye Park, Soma Saeidi, Hye-Kyung Na, Young-Joon Surh   +4 more
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PGAM5 expression levels in heart failure and protection ROS-induced oxidative stress and ferroptosis by Keap1/Nrf2

Clinical and Experimental Hypertension, 2023
Objectives As a common and frequently occurring disease, heart failure has been paid more and more attention, but the mechanism of its occurrence and development is still unclear.
Shuangfei Li, Ping Wen, Dayong Zhang, Decai Li, Qidong Gao, Hong Liu, Yunfeng Di   +6 more
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Thymoquinone attenuates brain injury via an antioxidative pathway in a status epilepticus rat model

Translational Neuroscience, 2017
Status epilepticus (SE) results in the generation of reactive oxygen species (ROS), which contribute to seizure-induced brain injury. It is well known that oxidative stress plays a pivotal role in status epilepticus (SE). Thymoquinone (TQ) is a bioactive
Shao Yi-ye, Li Bing, Huang Yong-mei, Luo Qiong, Xie Yang-mei, Chen Ying-hui   +5 more
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Sinapic Acid Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration

Journal of Inflammation Research, 2020
Jin-Feng Huang,1,2 Xuan-Qi Zheng,1,2 Jia-Liang Lin,3 Kai Zhang,4 Hai-Jun Tian,4 Wen-Xian Zhou,1,2 Hui Wang,1,2 Ze Gao,5 Hai-Ming Jin,1,2,* Ai-Min Wu1,2,* 1Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of ...
Huang JF, Zheng XQ, Lin JL, Zhang K, Tian HJ, Zhou WX, Wang H, Gao Z, Jin HM, Wu AM   +9 more
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Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology

Biomolecules, 2019
The integration of cell extrinsic and intrinsic signals is required to maintain appropriate cell physiology and homeostasis. Bone morphogenetic proteins (BMPs) are cytokines that belong to the transforming growth factor-β (TGF-β) superfamily ...
Cristina Sánchez-de-Diego, José Antonio Valer, Carolina Pimenta-Lopes, José Luis Rosa, Francesc Ventura   +4 more
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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Nature, 2011
Reactive oxygen species (ROS) are mutagenic and may thereby promote cancer. Normally, ROS levels are tightly controlled by an inducible antioxidant program that responds to cellular stressors and is predominantly regulated by the transcription factor ...
G. DeNicola, F. Karreth, Timothy J. Humpton, A. Gopinathan, Cong Wei, K. Frese, Dipti Mangal, Kenneth H. Yu, C. Yeo, Eric S. Calhoun, F. Scrimieri, J. Winter, R. Hruban, C. Iacobuzio-Donahue, S. Kern, I. Blair, D. Tuveson   +16 more
semanticscholar   +1 more source

Cytoprotective Effects of Delphinidin for Human Chondrocytes against Oxidative Stress through Activation of Autophagy

Antioxidants, 2020
Antioxidant enzymes are decreased in osteoarthritis (OA) patients, implying the role of oxidative stress in osteoarthritis pathogenesis. The aim of this study was to evaluate the cytoprotective effects of delphinidin, a potent antioxidant, in human ...
Dong-Yeong Lee, Young-Jin Park, Myung-Geun Song, Deok Ryong Kim, Sahib Zada, Dong-Hee Kim   +5 more
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