Results 41 to 50 of about 197,106 (353)

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.

Genes & Development, 1999
Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated induction of phase II detoxifying and oxidative stress enzyme genes.
K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, Kazuhiko Igarashi, J. D. Engel, Masayuki Yamamoto   +6 more
semanticscholar   +1 more source

Advances and challenges in therapeutic targeting of NRF2.

TIPS - Trends in Pharmacological Sciences, 2023
Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation, and metabolic imbalances.
A. Dinkova-Kostova, I. Copple
semanticscholar   +1 more source

Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids [PDF]

, 2014
The transcription factor Nrf2 protects against a number of experimental pathologies, and is a promising therapeutic target. The clinical investigation of a potent Nrf2-inducing agent, the triterpenoid (TP) bardoxolone methyl (BARD), was recently halted ...
Lister, Adam, Shelton, Luke M., Kratschmar, Denise V., Copple, Ian M., Park, B. Kevin, Goldring, Christopher E., Honda, Tadashi, Odermatt, Alex, Walsh, Joanne, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T.   +10 more
core   +1 more source

Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats

Antioxidants, 2019
Acute kidney injury (AKI) is a serious complication of methotrexate (MTX). This study explored the protective effect of the isoflavone formononetin (FN) against MTX nephrotoxicity with an emphasis on oxidative stress, inflammation, and nuclear factor ...
Saleem H. Aladaileh, Omnia E. Hussein, Mohammad H. Abukhalil, Sultan A. M. Saghir, May Bin-Jumah, Manal A. Alfwuaires, Mousa O. Germoush, Amer A. Almaiman, Ayman M. Mahmoud   +8 more
doaj   +1 more source

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Redox Biology, 2019
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is a key regulator of the cellular antioxidant response, controlling the expression of genes that counteract oxidative and electrophilic stresses.
M. Dodson, Raul Castro-Portuguez, Donna D. Zhang   +2 more
semanticscholar   +1 more source

Molecular Basis of the KEAP1-NRF2 Signaling Pathway

Molecules and Cells, 2023
Transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. NRF2 induces expression of detoxification and antioxidant enzymes and suppresses inductions of pro-inflammatory cytokine genes.
Takafumi Suzuki, Jun Takahashi, Masayuki Yamamoto   +2 more
semanticscholar   +1 more source

Nrf2 regulates ROS production by mitochondria and NADPH oxidase. [PDF]

, 2015
Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like ECH associated protein 1 (Keap1) thereby providing inducible antioxidant ...
Dinkova-Kostova, AT, Holmström, Kira M., Stjepana Kovaca, Kovac, S, Plamena R. Angelovaa, Ying Zhangb, Andrey Y. Abramova, Abramov, Andrey Y., Angelova, PR, Zhang, Y, Abramov, AY, Angelova, Plamena R., Kovac, Stjepana, Zhang, Ying, Kira M. Holmströma, Holmström, KM, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T., Albena T   +18 more
core   +1 more source

Effects of different-intensity exercise and creatine supplementation on mitochondrial biogenesis and redox status in mice [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Dietary supplementation combined with exercise may potentiate the beneficial effects of exercise by reducing exercise-induced oxidative stress and improving mitochondrial quality and capacity.
Seyhan Taskin, Hakim Celik, Seniz Demiryurek, Sibel Turedi, Abdullah Taskin   +4 more
doaj   +1 more source

Nrf2 Signaling in Macrophages [PDF]

Reactive Oxygen Species, 2016
The nuclear factor E2-related factor 2 (Nrf2) is known as the chief regulator of cellular antioxidant defenses as well as a suppressor of inflammation. Macrophages act as major players in inflammatory responses. Because oxidative stress and inflammation are two intertwined processes, the anti-inflammatory activity of Nrf2 signaling is believed to ...
Hong, Zhu, Zhenquan, Jia, Y Robert, Li
openaire   +2 more sources

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration [PDF]

, 2013
Transcription factor Nrf2 and its repressor Keap1 regulate a network of cytoprotective genes involving more than 1% of the genome, their best known targets being drug-metabolizing and antioxidant genes.
Iain Hargreaves, Land, John M., Kira M. Holmström, Andrey Y. Abramov, Chalasani, A, Annapurna Chalasani, Holmstrom, KM, Masayuki Yamamoto, Baird, Liam, Baird, L, John M. Land, Yamamoto, Masayuki, Lee Stanyer, Land, JM, Dinkova-Kostova, AT, Holmström, Kira M., Liam Baird, Albena T. Dinkova-Kostova, Ying Zhang, Abramov, Andrey Y., Zhang, Y, Hargreaves, Iain, Chalasani, Annapurna, Abramov, AY, Stanyer, L, Hargreaves, IP, Yamamoto, M, Zhang, Ying, Stanyer, Lee, Dinkova-Kostova, Albena T.; id_orcid   +29 more
core   +1 more source