Results 41 to 50 of about 157,133 (211)

Opposing effects of Nrf2 and Nrf2‐activating compounds on the NLRP3 inflammasome independent of Nrf2‐mediated gene expression [PDF]

European Journal of Immunology, 2017
The transcription factor Nrf2 regulates the expression of genes required for protection from xenobiotic and oxidative stress. Under normal conditions Nrf2 is constantly degraded upon ubiquitination, mediated by the Nrf2 inhibitor Keap1. Inflammasomes represent stress‐induced protein complexes.
Garstkiewicz, Martha, Strittmatter, Gerhard E, Grossi, Serena, Sand, Jennifer, Fenini, Gabriele, Werner, Sabine, French, Lars E, Beer, Hans-Dietmar   +7 more
openaire   +4 more sources

NRF2 signaling in cytoprotection and metabolism

British Journal of Pharmacology, 2023
The KEAP1-NRF2 system plays a central role in cytoprotection and defense mechanisms against oxidative stress. Because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and because NRF2 is a transcriptional factor regulating genes involved in the sulfur-mediated redox reactions, the KEAP1-NRF2 system has been regarded as a ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
openaire   +2 more sources

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

Cellular and Molecular Life Sciences, 2016
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a ...
A. Loboda, M. Damulewicz, E. Pyza, A. Józkowicz, J. Dulak   +4 more
semanticscholar   +1 more source

Nrf2 Regulates Oxidative Stress and Its Role in Cerebral Ischemic Stroke

Antioxidants, 2022
Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain, which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc.
Lei Wang, Xu Zhang, X. Xiong, Hua Zhu, Ran Chen, Shudi Zhang, Gang Chen, Z. Jian   +7 more
semanticscholar   +1 more source

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Nature, 2018
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function, but its precise mechanism of action remains poorly understood.
E. Mills, D. Ryan, H. Prag, D. Dikovskaya, D. Menon, Z. Zaslona, Mark P. Jedrychowski, Ana S. H. Costa, M. Higgins, E. Hams, John Szpyt, M. Runtsch, M. King, J. McGouran, R. Fischer, B. Kessler, A. F. Mcgettrick, M. Hughes, R. Carroll, Lee M. Booty, Elena V. Knatko, P. Meakin, M. Ashford, Louise K Modis, Gino Brunori, D. Sévin, P. Fallon, S. Caldwell, Edmund R. S. Kunji, Edward T. Chouchani, C. Frezza, A. Dinkova-Kostova, R. Hartley, M. Murphy, L. O’Neill   +34 more
semanticscholar   +1 more source

Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway

Redox Biology, 2022
The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical pathway has been extensively studied and reviewed in the past two decades, but rarely ...
Shengnan Liu, J. Pi, Qiang Zhang
semanticscholar   +1 more source

Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy

Antioxidants, 2023
The coordinating role of nuclear factor erythroid-2-related factor 2 (Nrf2) in cellular function is undeniable. Evidence indicates that this transcription factor exerts massive regulatory functions in multiple signaling pathways concerning redox ...
Mira Hammad, M. Raftari, Rute Cesário, Rima Salma, Paulo R D V Godoy, S. Emami, S. Haghdoost   +6 more
semanticscholar   +1 more source

NRF2-targeted therapeutics: New targets and modes of NRF2 regulation [PDF]

Current Opinion in Toxicology, 2016
Pharmacological activation of the transcription factor nuclear factor-erythroid derived 2-like 2 (NRF2), the key regulator of the cellular antioxidant response, has been recognized as a feasible strategy to reduce oxidative/electrophilic stress and prevent carcinogenesis or other chronic illnesses, such as diabetes and chronic kidney disease.
Montserrat, Rojo de la Vega, Matthew, Dodson, Eli, Chapman, Donna D, Zhang   +3 more
openaire   +2 more sources

Nrf2 Modulation in Breast Cancer

Biomedicines, 2022
Reactive oxygen species (ROS) are identified to control the expression and activity of various essential signaling intermediates involved in cellular proliferation, apoptosis, and differentiation. Indeed, ROS represents a double-edged sword in supporting cell survival and death.
Somayyeh Ghareghomi, Mehran Habibi-Rezaei, Marzia Arese, Luciano Saso, Ali Akbar Moosavi-Movahedi   +4 more
openaire   +3 more sources

Apigenin Alleviates Allodynia and Hyperalgesia in a Mouse Model of Chemotherapy-Induced Peripheral Neuropathy via Regulating Microglia Activation and Polarization

Journal of Integrative Neuroscience, 2023
Background: Apigenin has been reported to exhibit anti-inflammatory and anti-oxidative activities. This study aimed to investigate the protective role of Apigenin on chemotherapy-induced peripheral neuropathy (CIPN).
Wenji Xie, Wenqin Xie, Changcheng Jiang, Zhenming Kang, Naizhen Liu   +4 more
doaj   +1 more source