Results 51 to 60 of about 157,133 (211)
Archives of Pharmacal Research, 2019 Liver plays essential roles in the metabolism of many endogenous chemicals and exogenous toxicants. Mechanistic studies in liver have been at the forefront of efforts to probe the roles of bioactivation and detoxication of environmental toxins and toxicants in hepatotoxicity.
Keiko Taguchi, Thomas W. Kensler
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Cell StressDifferential and even opposing functions of two major antioxidant transcription factors Nrf1 and Nrf2 (encoded by Nfe2l1 and Nfe2l2, respectively) are determined by distinctions in their tempospatial positioning, topological repartitioning, proteolytic ...
Yiguo Zhang +8 more
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Translational Neuroscience, 2022 Parkinson’s disease (PD) is a common neurodegenerative disease that severely affects the quality of life of patients. There is no specific drug for PD up to now.
Huang Lijuan +4 more
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The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.
Physiological Reviews, 2018 The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system forms the major node of cellular and organismal defense against oxidative and electrophilic stresses of both exogenous and endogenous origins.
Masayuki Yamamoto +2 more
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Journal of Inflammation Research, 2022 Yunxiao Zhong,1,* Xiaodong Cai,2,* Li Ding,3,* Jinchi Liao,1 Xu Liu,1 Yiying Huang,1 Xiaohong Chen,1 Ling Long1 1Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, 510600, People’s
Zhong Y +7 more
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NRF2 molecule of the month [PDF]
Bioinformation, 2012 NRF2 – nuclear factor erythroid 2-related factor 2 is also known as GA binding protein transcription factor, alpha subunit 60kDa- GABPA [1, 2]. A recent literature review suggests that NRF2 has complex regulatory roles in cancer. NRF2 is a transcription factor and is upregulated by oncogenes.
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Journal of Inflammation Research, 2021 Chien-Chung Yang,1,2 Chuen-Mao Yang3– 5 1Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Tao-Yuan, Kwei-San, Tao-Yuan, 33302, Taiwan; 2School of Traditional Chinese Medicine, College of Medicine, Chang Gung University ...
Yang CC, Yang CM
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The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
Molecular and Cellular Biology, 2020 The KEAP1-NRF2 pathway is the principal protective response to oxidative and electrophilic stresses. Under homeostatic conditions, KEAP1 forms part of an E3 ubiquitin ligase, which tightly regulates the activity of the transcription factor NRF2 by ...
Liam Baird, Masayuki Yamamoto
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The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging
Oxidative Medicine and Cellular Longevity, 2021 Oxidative stress, a term that describes the imbalance between oxidants and antioxidants, leads to the disruption of redox signals and causes molecular damage.
Chao Yu, Jian-Hui Xiao
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Redox Experimental MedicineObjective: Transcription factor NRF2, master regulator of the antioxidant response, is also involved in brain development. This paper investigated the role of NRF2 in developmental zinc deficiency-associated alterations in rat brain cortex: i ...
Wei Zhu, Patricia I Oteiza
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